- Y723
- +852 3400 8667
- wilson-cy.lau@polyu.edu.hk
ORCID ID
SCOPUS IDResearch Overview
My research focuses on structural studies on macromolecular assemblies using state-of-the-art cryo-electron microscopy (cryo-EM). Specifically, my groups is interested in elucidating the structure-function relationship of biological machines and ligand discovery against 'undruggable' targets through rational design.
Education and Academic Qualifications
- Honours Bachelor of Science, University of Toronto
- Doctor of Philosophy, University of Toronto
Research Interests
Achievements
- Yuan, D., Zhang, Y., Lim, K.H., Leung, S.K.P., Yang, X., Liang, Y., Lau, W.C.Y., et al.(2022). Site-Selective Lysine Acetylation of Human Immunoglobulin G for Immunoliposomes and Bispecific Antibody Complexes. J Am Chem Soc., 144, 18494
- Li, B., Zeng, Y., Cao, W., Zhang, W., Cheng, L., Yin, H., Wu, Q., Wang, X., Huang, Y., Lau, W.C.Y., et al.(2021). A distinct giant coat protein complex II vesicle population in Arabidopsis thaliana. Nature Plants, 7, 1335
- Yu, C., Leung, K.P., Zhang, W., Lai, L.T.F., Chan, Y.K., Wong, M.C., Benlekbir, S., Jiang, L., and Lau, W.C.Y. * (2020). Structural basis of substrate recognition by a small heat shock protein. Nature Communications, 12, 3007
- Lai, L.T.F., Yu, C., Wong, J.S.K., Lo, H.S., Benlekbir, S., Jiang, L. and Lau, W.C.Y.* (2020). Subnanomter resolution cryo-EM structure of Arabidopsis thaliana ATG9. Autophagy, 16, 575
- Lai, L.T.F., Ye, H., Zhang, W., Jiang, L. and Lau, W.C.Y. * (2019). Structural biology and Electron Microscopy of the Autophagy Molecular Machinery. Cells, 8, pii: E1627
- Kang, W., Ma, T., Liu, W., Qu, J., Liu, Z., Zhang, H., Shi, B., Fu, S., Ma, J., Lai, L.T.F., He, S., Qu, J., Au, S.W., Kang, B.H., Lau, W.C.Y., et al. (2019). Modular enzyme assembly for enhanced cascade biocatalysis and metabolic flux. Nature Communications, 10, 4248
- Sy, K.H.S., Ho, L.W.C., Lau, W.C.Y., Ko, H. and Choi, C.H.J. (2018). Morphological Diversity, Protein Adsorption, and Cellular Uptake of Polydopamine-Coated Gold Nanoparticles. Langmuir, 34, 14033
- Lau, W.C.Y. #,*, Li, Y., Liu, Z., Gao, Y., Zhang, Q. and Huen, M.S.Y. (2016). Structure of the human dimeric ATM kinase. Cell Cycle, 15, 1117
- Roh, S.H., Kasembeli, M., Galaz-Montoya, J.G., Trnka, M., Lau, W.C.Y., Burlingame, A., Chiu, W. and Tweardy, D.J. (2016). Chaperonin TRiC/CCT Modulates the Folding and Activity of Leukemogenic Fusion Oncoprotein AML-ETO. Journal of Biological Chemistry, 291, 4732
- Lau, W.C.Y. #,*, Li, Y., Zhang, Q. and Huen, M.S.Y. (2015). Molecular architecture of the Ub-PCNA/Pol eta complex bound to DNA. Scientific Reports, 5, 15759
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Kasembeli, M., Lau, W.C.Y., Roh, S., Eckols, Frydman, J., Chiu, W. and Tweardy, D.J. (2014). Modulation of STAT3 Folding and Function by TRiC/CCT Chaperonin. PLOS Biology, 12(4):e1001844
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Lau, W.C.Y. # and Rubinstein, J.L. (2013). Single particle electron microscopy. Methods inMolecular Biology, 955, 401
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Lau, W.C.Y. # and Rubinstein, J.L. (2012). Subnanometer-resolution structure of the intact T. thermophilus H+-driven ATP synthase.
Nature, 481, 214 -
Lau, W.C.Y. # and Rubinstein, J.L. (2009). Structure of intact Thermus thermophilus V-ATPase by cryo-EM reveals organization of the membrane-bound V(O) motor. PNAS, 107, 1367
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Lau, W.C.Y. #, Baker, L.A. and Rubinstein, J.L. (2008). Cryo-EM structure of the yeast ATP synthase. Journal of Molecular Biology, 382, 1256
