A term from our Department, led by Dr. Larry Ming-cheung Chow and Prof. Bill Tak-hang Chan, has won a Gold Medal and a Special Award from the Romanian Delegation at the 41stInternational Exhibition of Inventions of Geneva. This year, the winning project was presented at a press conference hosted by Mr. Nicholas W. Yang, Executive Vice President of the University on PolyU campus on 8 May 2013. The project titled "Novel Flavonoid Dimers for Reversing Cancer Drug Resistance" has successfully designed small molecules to reverse the multidrug resistance (MDR) process extensively observed in cancer treatment.
Nowadays, chemotherapy is commonly used for treating cancer while multidrug resistance (MDR) remains a major problem. Dr. Chow and Prof. Chan's team has designed small molecules to reverse this process. Membrane proteins P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP) pump drugs out of cancer cells and reduce chemotherapy efficacy. The team has designed, synthesized and characterized novel diet-derived flavonoid dimers which can target P-gp and BCRP's dimeric structure. Due to the unique design of dimeric structure which can specifically bind to the pseudodimeric P-gp and BCRP, these flavonoid dimers can inhibit P-gp and BCRP, and reverse cancer drug resistance with very high potency (inhibiting BCRP at < 1 nM) and low toxicity (therapeutic index of 1x105).
Let us congratulate Dr. Chow and Prof. Chan on receiving this award.
Nowadays, chemotherapy is commonly used for treating cancer while multidrug resistance (MDR) remains a major problem. Dr. Chow and Prof. Chan's team has designed small molecules to reverse this process. Membrane proteins P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP) pump drugs out of cancer cells and reduce chemotherapy efficacy. The team has designed, synthesized and characterized novel diet-derived flavonoid dimers which can target P-gp and BCRP's dimeric structure. Due to the unique design of dimeric structure which can specifically bind to the pseudodimeric P-gp and BCRP, these flavonoid dimers can inhibit P-gp and BCRP, and reverse cancer drug resistance with very high potency (inhibiting BCRP at < 1 nM) and low toxicity (therapeutic index of 1x105).
Let us congratulate Dr. Chow and Prof. Chan on receiving this award.
