This project aims to develop a series of green disinfectants based on poly (3-hydroxybutyrate) (PHB) oligomer and its homologues, using a rapid synthesis technique which involves cost-effective processes. The disinfectants produced in this way demonstrate wide-spectrum anti-microbial properties against fungi and bacteria, with a remarkable anti-bacterial rate of over 99.99%. They can effectively kill influenza viruses, such as H1N1 and H3N2, with an anti-viral activity rate of 99.99%. Moreover, these disinfectants are non-toxic and biodegradable, and can be applied as aqueous coating solutions over facemasks and other personal protection equipment for enhanced disinfection efficacy.