Research at FAST

50 Dr LEE Man Yuen Leo Research Assistant Professor Research Areas Development of drugs for prevention and treatment of obesity-related metabolic disorders and cancer, and aging-related diseases Retinoic acid signaling in embryo and development of therapeutic interventions to combat against the adverse effects of maternal diabetes and obesity on fetal development Qualification BSc (PolyU) MPhil (CUHK) PhD (CUHK) ORCID ID 0000-0002-2089-9311 Representative Publications • Lee LMY , Leung MBW, Kwok RCY, Leung YC, Wang CC, McCaffery PJ, Copp AJ and Shum ASW ( 2017 ). Per turbation of retinoid homeos t asis increases malformation risk in embryos exposed to pregestational diabetes. Diabetes 66, 1041-1051 • Lee LMY , Leung CY, Tang WWC, Choi HL, Leung YC, McCaffery PJ, Wang CC, Woolf AS and Shum ASW ( 2012 ). A paradoxical teratogenic mechanism for retinoic acid. Proc Natl Acad Sci USA 109, 13668-13673 Book Chapter • Lee LMY , Tam STK, McCaffery PJ and Shum ASW ( 2019 ). Highly sensitive quantitative determination of retinoic acid levels, retinoic acid synthesis, and catabolism in embryonic tissue using a reporter cell-based method. In: Ray SK (eds) Retinoid and Rexinoid Signaling. Methods and Protocols. Methods in Molecular Biology vol 2019, p.181-192, Humana Press, New York Patent • Methods for Inducing Intermittent Fasting and Modulating Autophagy (US Provisional Application for Patent No. 62/942,354. Filed on 2 Dec 2019 ) Department of Applied Biology & Chemical Technology Department of Applied Biology & Chemical Technology