Research at FAST

53 Representative Publications • Chung SF, Kim CF, Tam SY, Choi MC, So PK, Wong KY, Leung YC , Lo WH. A bioengineered arginine-depleting enzyme as a long-lasting therapeutic agent against cancer. Appl Microbiol Biotechnol. 2020 Mar 6. doi: 10.1007/s00253-020-10484-4 • Wang H, Li QF, Chow HY, Choi SC, Leung YC . Arginine deprivation inhibits pancreatic cancer cell migration, invasion and EMT via the down regulation of Snail, Slug, Twist, and MMP1/9. J Physiol Biochem. 2020 Feb;76(1):73-83. doi: 10.1007/s13105-019-00716-1 • Au HW, Tsang MW, So PK, Wong KY, Leung YC . Thermostable β -lactamase mutant with its active site conjugated with fluorescein for efficient β -lactam a n t i b i o t i c d e t e c t i o n . ACS Ome g a . 2 019 N o v 27;4(24):20493-20502. doi: 10.1021/acsomega.9b02211 • Tsang MW, Chan PH, Liu SY, Wong KY, Leung YC . A fluorescein-labeled AmpC β -lactamase allows rapid characterization of β -lactamase inhibitors by real-time fluorescence monitoring of the β -lactamase-inhibitor interactions. Biotechnol J. 2016 Feb;11(2):257-65. doi: 10.1002/biot.201400861 • Tsang MW, So PK, Liu SY, Tsang CW, Chan PH, Wong KY, Leung YC . Catalytically impaired fluorescent class C β -lactamase enables rapid and sensitive cephalosporin detection by stabilizing fluorescence signals: implications for biosensor design. Biotechnol J. 2015 Jan;10(1):126-35. doi: 10.1002/biot.201400140 Awards and Achievements • PolyU Distinguished Knowledge Transfer Award 2017 (TEC- Merit Award) • PolyU Outstanding Professional Service Award 2017 (Winner, Technology Transfer Award) • Second Class Prize in Natural Science Award of the Higher Education Outstanding Scientific Research Output Awards (Science and Technology) from the Ministry of Education ( 2013 ) • H i gh Impac t Achi evement Award fo r Re s earch Achievement ( 2009 ) • Prize of the State of Geneva ( 2009 ) • Two Technology Transfer Awards ( 2005 and 2006 ) • President’s Award for Excellent Performance/Achievement in Research and Scholarly Activities ( 2004 / 2005 ) Prof. LEUNG Yun Chung Thomas Lo Ka Chung Charitable Foundation Professor in Pharmaceutical Sciences Professor Director of University Research Facility in Life Sciences Research Areas Drug discovery; Pharmaceutical sciences; Protein engineering; Rational protein drug design; Rational biosensor design; Translational medicine; Biotechnology and cancer research Qualification BSc (Imperial) DPhil (Oxford) ORCID ID 0000-0003-3590-7027 Department of Applied Biology & Chemical Technology Department of Applied Biology & Chemical Technology