Research at FAST

66 Representative Publications • J. Endo. Soc. 2020 , 4(2): bvz025 • J. Ginseng. Res. 2019 , 43(4): 527-538 • J. Nutr. 2018 , 148(12): 1895-1902 • Front. Pharmacol. 2018 , 9: 932 • Front. Pharmacol. 2018 , 9: 779 • Nutrients 2018 , 10(2): E247 • Br. J. Pharmacol. 2010 , 159(4): 939-949 • Br. J. Pharmacol. 2009 , 156(7): 1136-46 • J Clin. Endo. Metab. 2004 , 89(5): 2351-2359 • J Clin. Endo. Metab. 2002 , 87(8): 3691-3695 Awards and Achievements • 國家教育部 2013 年度高等學校科學研究優秀成果獎（科學 技術）( 科技進步獎 ) • Shenzhen Virtual University Park National Technology Project Pioneer Award, Shenzhen Technology and Innovation Committee 2012 Prof. WONG Man Sau Professor Associate Dean of Faculty of Applied Science and Textiles Research Overview The primary focus of our laboratory is to study the use of dietary factors (nutrients and phytochemicals) and Chinese medicinal herbs (its bioactive fractions and ingredients) for improving bone health and prevention of age-related diseases as well as to delineate the mechanisms involved in mediating their protective effects. Our recent work includes the study of the mechanisms that account for the tissue-selective estrogenic effects of Chinese herbs (bioactive compounds or decoction), such as icariin (Figure 1); the use of metabolomic approach to identify novel targets that mediate the osteoprotective actions of lignans fractions of Sambucus Williamsii Ramulus in aged rats (Figure 2); and the characterization of the changes in microbial comopsitions and serum short chain fatty acids (SCFAs) in ovariectomized rats in association with the osteoprotective effects of Erythrinae cortex extract (Figure 3). Qualification BSc (U Illinois at Urbana-Champaign) PhD (U Chicago) ORCID ID 0000-0002-0729-8618 Figure 1 Figure 2 Figure 3 Patents • 異戊烯基二氫黃酮類化合物在防治骨疾病領域的應用。中國 專利。 CN 107115445B 2019-11-19 Granted ( 2019 ) • 具有降低絕經期婦女骨相關疾病發病風險的接骨木活性 部位及其應用。中國專利。 2013-02-20 CN101773490B Granted ( 2013 ) Department of Applied Biology & Chemical Technology Department of Applied Biology & Chemical Technology