Research at FAST

70 Representative Publications • Adv. Mater. 2020 , 32, 1906872-83 • J. Am. Chem. Soc. 2019 , 141, 9610-16 • Proc. Natl. Acad. Sci. USA 2019 , 116, 26614-24 • Adv. Healthc. Mat. 2019 , 8, 1900575-83 • Chem. Sci. 2019 , 10, 4550-9 • Nano Energy 2019 , 56, 473-81 • Nat. Commun. 2018 , 9, 1283 • Nat. Commun. 2017 , 8, 1128 • Nat. Biomed. Eng. 2017 , 1, 0042 • Nat. Commun. 2016 , 7, 11978 • Chem. Sci. 2016 , 7, 2151-56 • PLoS ONE. 2016 , 11, e0162217 Awards and Achievements • Outstanding Achievement Award in Scientific Research for Institution of Higher Education of China ( 2012 ) • Croucher Senior Research Fellowship, The Croucher Foundation ( 2004 ) • Doctor of Science, University of Cambridge, UK ( 2000 ) Patents • Methods and catalysts for green biodiesel production from unrefined low grade feedstock US9694350B2 ( 2017 ) • Paramagnetic Complexes with Pendant Crown Compounds Showing Improved Targeting- Specificity as MRI Contrast Agents US2009104124A1 ( 2009 ) • Optimized relaxivity and specificity hepatobiliary MRI contrast agent US20070116648A1 ( 2007 ) • Synthesis of tris n-alkylated 1,4,7,10-tetraazacyclododecanes WO2005003105 ( 2005 ) Research Overview The research areas of Prof. Wong mainly include the development of molecular probes for biological imaging and X-ray crystallography. A wide range of lanthanide-based materials have been developed for optical and magnetic resonance imaging applications while their fundamental properties are thoroughly investigated for performance optimization. Below are in vitro multi-photon confocal microscopy images of a Eu(III) complex (red) in HeLa cells showing lysosome localization by co-staining with LysoTracker® (green). Qualification BSc (HKU) MPhil (HKU) PhD (Cambridge) ORCID ID 0000-0002-3453-1825 The self-assembly of chiral lanthanide supramolecular structures with unique circularly polarized luminescence properties are also being studied in Prof. Wong’s research group. By careful design and synthesis of ligands, the self- assembly behavior with lanthanide precursors could be controlled and the group is currently working on harnessing these assemblies for various applications. Figure 1 Figure 2 In addition, Prof. Wong is interested in the design and development of biomarker sensors for diagnostic and therapeutic purposes. The image below shows how an emissive probe were able to give distinct fluorescent responses towards Zn(II) and EBNA1, a viral protein associated with Epstein-Barr virus-related malignancies. Figure 3 Prof. WONG Wing Tak Chair Professor of Chemical Technology Deputy President and Provost Department of Applied Biology & Chemical Technology Department of Applied Biology & Chemical Technology