Research at FAST

78 Representative Publications • Autophagy ( 2019 ) 16(5): 917-931 • Proc. Natl. Acad. Sci. U.S.A. ( 2018 ) 115(25): E5669-E5678 • Biol. Chem. ( 2017 ) 292(10): 4022-4033 • PLOS Genetics ( 2015 ) 11(2): e1004987 • Nucleic Acids Res. ( 2014 ) 42(20): 12899-12911 • Autophagy ( 2012 ) 8(8): 1258-1260 • Nature Communications ( 2012 ) 3: 662 • J. Biol. Chem. ( 2011 ) 286(36): 31771-31780 • Cell ( 2009 ) 138(3): 537-548 Prof. ZHAO Yanxiang Professor Research Overview Our lab is interested in understanding the molecular mechanism of autophagy, an important cellular process that degrades and recycles cytosolic content in lysosome-dependent manner. This process is critical for maintaining cellular homeostasis and has been implicated in a variety of human diseases including cancer, diabetes and neurodegeneration. Our research aim is structure-based mechanistic study of autophagy molecular machinery. One current project focuses on the Beclin1-Vps34 complex, a membrane associated Class III lipid kinase responsible for autophagy induction. Beclin1 recruits Atg14L to regulate this complex. (Li et. al. Nature Communications 2012; Li et. al. Autophagy 2012; McKnight et. al. PLOS Genetics 2014 Autophagy, Wu et. al. PNAS 2018) Qualification BSc (PKU) MA (SBU) PhD (Rockefeller) ORCID ID 0000-0002-9408-9979 Department of Applied Biology & Chemical Technology Department of Applied Biology & Chemical Technology