DEPARTMENT OF FOOD SCIENCE AND NUTRITION 146 Email xiaoli.dong@polyu.edu.hk Qualification BSc (Jining Medical College) MPhil (Qingdao University Medical College) PhD (The Hong Kong Polytechnic University) ORCID ID 0000-0002-7372-0450 Representative Publications • Nutrients, 2023, 15(1): 11 • Food Research International, 2022, 155: 111067 • Molecular Nutrition & Food Research, 2022, 66(2): e2100739 • Frontiers in Aging Neuroscience, 2021, 13: 649627 • International Journal of Biological Macromolecules, 2020, 164: 994-1005 Patents • 一種納米硒水溶膠及其製備方法與應用。中國專利，ZL 2019 1 1215358.5 • 維生素 D 補充製劑及其應用。中國專利，ZL 2019 1 0764988.1 • 齊敦果酸和熊果酸在製備調節維生素D3代謝酶活性的藥物 中的應用。中國專利，ZL 2017 1 1061004.0 • 異戊烯基二氫黃酮類化合物在防治骨疾病領域的應用。 中國專利，ZL 2016 1 0102211.5 • 三萜類化合物在製備治療帕金森藥物中的應用。中國專利， ZL 2015 1 0673284 Professional Service • Guest editor of “Nutrients” Awards and Achievements • Rational design of oral drug delivery system for celastrol as a novel catechol-O-methyltransferase inhibitor to treat Parkinson’s disease; HMRF; HKD$1,200,000; 2023-2026; PI • Studies on the guideline medicine plus modified Huang Lian Jie Du Decoction as new therapy strategies on Parkinson's disease based on its molecular immune mechanisms. Guangdong Provincial Enterprise Joint Fund; RMB¥500,000; 2023-2026 Co-I • 第七屆海峽兩岸暨港澳營養科學大會，優秀論文獎 , 2022 • Preparation of nano-selenium functionalized by Cordyceps polysaccharide for development of functional products to prevent osteoporosis; RMB¥4,000,000; 2021-2024; Co-I • Evaluation of the effects of enhanced placental transport and brain uptake of DHA for the prevention of perinatal brain injury in preterm birth; HMRF; HKD$1,497,000; 2020-2023; Co-I • Rational design of selenium nanosystem for multi-targeted drug delivery and treatment of Parkinson's disease; Shenzhen Fundamental Research Program; RMB¥1,500,000; 20202023; Co-I • Investigation of neuroprotective effects and mechanisms of novel selenium nanoparticles for prevention of Parkinson’s disease; HMRF; HKD$1,500,000; 2019-2023; PI • Evaluation of anxiolytic and antidepressant effects of colonspecific delivery and control-release of probiotics on brain and behavior using a mouse model of social defeat stress; HMRF; HKD$1,197,000; 2018-2022; Co-I • Clinical investigation on marine polysaccharides in combination with probiotics for treatment of Parkinson's disease via modulating intestinal microbiota; Shenzhen Fundamental Research Program; RMB¥2,000,000; 20182021; Co-PI • Molecular mechanism investigation on maslinic acid targeting at pivotal proteins in autophagy pathways for degradation of aggregated α-synuclein in neuron cells; NSFC; RMB¥170,000; 2017-2019; PI • Molecular mechanism studies of oleanolic acid and its natural derivatives as autophagy inducers for treatment of Parkinson's disease; Shenzhen Fundamental Research Program; RMB¥300,000; 2015-2017; PI Dr DONG Xiaoli Research Assistant Professor Research Overview My research interests include pathogenic mechanism studies of neurodegenerative diseases, novel therapy (especially food-based therapies) development for the treatment of neurodegenerative diseases and functional food development for mental health.
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