DEPARTMENT OF APPLIED BIOLOGY & CHEMICAL TECHNOLOGY 35 Email ben.ko@polyu.edu.hk Qualification BSc (The University of Hong Kong) PhD (The University of Hong Kong) ORCID ID 0000-0003-2027-5899 Dr KO Chi-bun Ben Associate Professor Research Overview Our research covers three main areas: (1) Novel drug discovery and therapeutic mechanisms of drugs We are interested in the identification of novel therapeutic molecules using high-content screening, elucidation of cellular target of natural products using mult-omics and chemical biology analysis, as well as understanding the exceptional response of targeted therapy of cancers (2) Pathogenesis of hepatocellular carcinoma We investigate the pathogenic mechanisms of the cancer from the perspective of transcriptional and epigenetic dysregulations, particularly focusing on how the dysregulations alter cellular energy metabolisms (3) Cellular response to stress We sought to understand how mammalian cells are adapted to osmotic stress, particularly the functions and regulations of NFAT5, the only tonicity-regulated transcription factor in mammals, in the process Representative Publications • Journal of Cell Science, 2022; 135(13):jcs259280 • Sensors Actuators B: Chemical, 2022; 367, 132003 • Dyes and Pigments, 2022; 205, 110541 • RSC Advances, 2021; 11, 33294-33299 • Frontiers in Immunology, 2021; 12, 679184 • Journal of Pathology, 2017; 243:418-430 • Hepatology, 2013; 57(6):2287-2298
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