DEPARTMENT OF APPLIED BIOLOGY & CHEMICAL TECHNOLOGY 38 Email terence.kw.lee@polyu.edu.hk Qualification BSc (The Hong Kong University of Science and Technology) MPhil (The University of Hong Kong) PhD (The University of Hong Kong) ORCID ID 0000-0003-0682-322X Prof. LEE Kin-wah Terence Professor Associate Head of Department Research Overview My research focuses on translational cancer research using hepatocellular carcinoma (HCC) as a model system. My group is interested in: (1) identification, characterisation, niche interaction and therapeutic targeting of liver tumour-initiating cells (T-ICs)/cancer stem cells (CSCs) (2) investigating the molecular mechanisms of cancer metastasis (3) understanding the molecular aspects of cancer drug resistance, including molecularly targeted drugs and immune therapy (4) pivotal role of gut microbiota in cancer development, in the hope to translate our basic research into better survival and improved quality of life of cancer patients We are using sophisticated cell culture model system, omics approach and patient-derived xenograft as our research platform. Representative Publications • JHEP. Rep. 2022, 100604 • Cancer Res. 2022, 3102-3115 • Nat. Rev. Gastroenterol. Hepatol. 2022, 26-44 • Cancer Res. 2021, 3229-3240 • Hepatology 2020, 155-168 • Cancer Res. 2018, 2332-2342 • J. Hepatol. 2017, 979-990 • Hepatology 2015, 534-545 • Hepatology 2014, 179-191 • Cell Stem Cell 2011, 50-63 • Hepatology 2010, 160-710 Patents • “Monoclonal antibody for predicting tamoxifen response in breast cancer patients” (US10823735B2), 2020 • “The use of HCN inhibitors for treatment of cancers” (Co-I) (WO2018196782), 2018 Awards and Achievements • Faculty Award in Research and Scholarly Activities, 2022 • Outstanding Research Output Award, Li Ka Shing Faculty of Medicine, HKU, 2022 • Outstanding Research Output Award, Li Ka Shing Faculty of Medicine, HKU, 2018 • Outstanding Research Output Award, Li Ka Shing Faculty of Medicine, HKU, 2012 • Outstanding Research Output Award, Li Ka Shing Faculty of Medicine, HKU, 2011 • Council member of Hong Kong Society for Cell Biology (HKSCB) • Active member of American Association for Cancer Research
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