DEPARTMENT OF APPLIED BIOLOGY & CHEMICAL TECHNOLOGY 67 Email lei.henry.zhou@polyu.edu.hk Qualification BSc (Shanghai Normal University) MSc (Shanghai Normal University) PhD (National University of Singapore) ORCID ID 0000-0001-5893-6002 Prof. ZHOU Lei Professor Joint appointment with ABCT and School of Optometry Research Areas Prof. Zhou applies cutting-edge mass spectrometry and proteomics/metabolomics technologies to biomedical research. He pioneered the comprehensive analysis of the human tear fluid proteome and metabolome, which enabled major advances in disease diagnosis using tear proteins. His laboratory has been systematically investigating tear proteomic profiles and disease biomarkers for more than twenty eye and systemic diseases. His team has banked more than 6,000 tear proteins and a few hundred small molecule metabolites in their human tear fluid database. He is taking a trans-omics/multi-omics approach to identify disease biomarkers that could be used for diagnosis, prognosis, monitoring disease progression, response to treatment, and disease risk prediction. Such an approach has also been used for studying disease mechanisms and identifying protective factors for age-related eye diseases. Prof. Zhou is particularly interested in diabetic retinopathy, age-related macular degeneration, myopia, and ocular surface diseases. His research also involves developing new methods for proteomics (e.g. post-translational modifications on cysteine residues, such as glutathionylation) and metabolomics (e.g. data-independent acquisition in metabolomics). Representative Publications • Diabetes, 2022, Nov 29; db220611 • Cellular and Molecular Life Sciences, 2022, Nov 21; 79(12): 599 • Ophthalmology, 2022, Mar;129(3): 285-294 • Signal Transduction and Targeted Therapy, 2021, Sep 22; 6(1): 336 • Journal of Advanced Research, 2021, 29: 67-81 • Molecular and Cellular Proteomics, 2018, 17(10): 2034-2050 • Analytical Chemistry, 2017, 89(9): 4897-4906 • Nature Communications, 2016, Mar 29; 7:11008 • Diabetes, 2016, Apr;65(4): 1099-1108 • Progress in Retinal and Eye Research, 2012, 31(6): 527-550 Patents • WO/2007/126391 • WO/2007/126392 • WO/2009/131548 • WO/2013/036207 • WO/2015/038069 Achievement • Outstanding Achievement Award in Ophthalmology and Visual Science for Overseas Chinese, Chinese Ophthalmological Society, 2020 Human Tear Fluid Chemical Composition Tear Proteomic Profiles in Ocular Diseases and Systemic Diseases
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