Microfluidic platform for infection models

Current technology using microfluidics focuses on the use of cells to study biomedical process. However, the benefits of microfluidics, such as small sample size and high-throughput screening capabilities, have not been translated into any fish-microbe (pathogenic, non-pathogenic, and commensal) study. It is the most suitable choice for the development of vertebrate-microbe interaction models, so we designed MicroFish. Roughly, MicroFish consists of designable gradient concentration tree channels, fish growing channels, pump and observation device.

After the treated by testing samples, through observation, the fluorescent biomarkers we designed can be recognized as the indicator. From our lab works, based on the high designability and modularity of MicroFish, it can be applied into the chemical compounds or new drugs discovery after auto screening, antibiotics application for infection, environmental pollutants detection, and water pathogens testing.

Team Member(s):

LIU YANG

Chan Yuen

Dr. CHUA Song Lin