Chinese Herb Huperzine A-derived Dimers for Osteochondral Repair
It is hypothesized that the compounds can exert anti-inflammatory effects and create a pro-regenerative environment in favor of osteochondral repair in OA joints. The candidate herb-derived molecules, i.e. hupyridone, bis(12)-hupyridone (E12E) and hupyridone(10)- tacrine (A10E), will be tested in the following aims: Aim 1 is to decipher drug release kinetics after loading onto self-developed injectable scaffolds, and Aim 2 is to examine the efficacy of the dimers in established osteochondral defect rabbit models.
The data obtained in a preclinical setting of drug release and efficacy will lay a solid foundation for lead optimization and patent filing towards clinical translation.
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