助理教授（研究）

李烨博士

助理教授（研究）

BVetMed (ZJU), MPhil (UCAS), PhD (CUHK)

ST524
+852 2766 4842
ye-julie.li@polyu.edu.hk
运动科学和肌肉骨骼健康

简历

李烨博士在浙江大学获得兽医学学士学位，在中国科学院大学获得生物医学工程硕士学位，并在香港中文大学获得骨创伤学博士学位。在加入香港理工大学之前，她曾分别在香港中文大学和中国科学院香港创新研究院担任博士后研究员。

李博士在镁基材料用于骨缺损癒合、张成骨用于骨缺损修复、局部递送CGRP用于组织修复、前交叉韧带（ACL）重建和脉衝电磁场（PEMF）用于软骨修复方面有研究经验。目前，李博士对可穿戴设备用于骨关节炎康复、传统中药用于组织再生和肌肉骨骼疾病的治疗感兴趣。

学历

• Bachelor of Veterinary Medicine, Zhejiang University
• Master of Philosophy in Biomedical Engineering, University of Chinese Academy of Sciences
• Doctor of Philosophy in Orthopaedics and Traumatology, The Chinese University of Hong Kong

研究兴趣

研究成果

Li Y, Xu J, Mi J, He X, Pan Q, Zheng L, Zu H, Chen Z, Dai B, Li X, Pang Q, Zou L, Zhou L, Huang L, Tong W, Li G, Qin L. Biodegradable magnesium combined with distraction osteogenesis synergistically stimulates bone tissue regeneration via CGRP-FAK-VEGF signaling axis. Biomaterials, 2021, 275: 120984.
Lai Y, Li Y (equal first author), Cao H, Long J, Wang X, Li L, Li C, Jia Q, Teng B, Tang T, Peng J, Eglin D, Alini M, Grijpma D, Richards G, Qin L. Osteogenic magnesium incorporated into PLGA/TCP porous scaffold by 3D printing for repairing challenging bone defect. Biomaterials, 2019, 197: 207-219.
Li Y, Pan Q, Xu J, Li G, Qin L. Overview of methods for enhancing bone regeneration in distraction osteogenesis: Potential roles of biometals. Journal of Orthopaedic Translation, 2021, 27: 110-118.
Pan Q, Li Y (equal first author), Li Y, Lin S, Li G. Local administration of allogeneic or autologous bone marrow-derived mesenchymal stromal cells enhances bone formation similarly in distraction osteogenesis. Cytotherapy, 2021, 23(7): 590-598.
Li Y, Chen SK, Li L, Qin L, Wang X, Lai Y. Bone defect animal models for testing efficacy of bone substitute biomaterials. Journal of Orthopaedic Translation, 2015, 3(3): 95-104.
Li Y, Li L, Li Y (equal first author), Feng L, Wang B, Wang M, Wang H, Zhu M, Yang Y, Waldorff E, Zhang N, Viohl I, Lin S, Bian L, Lee W, Li G. Enhancing cartilage repair with optimized hydrogel-based scaffold with pulsed electromagnetic field. Bioactive Materials, 2023, 22: 312-324.
He X, Li Y (equal first author), Miao H, Sun J, Ong M, Zu H, Li W. The bioactive Mg-Zn-Gd wire enhances musculoskeletal regeneration: An in vitro study. Crystals, 2022, 12(9): 1287.
Li X, Dai B, Guo J, Zhu Y, Xu J, Xu S, Yao Z, Chang L, Li Y, He X, Chow D, Zhang S, Yao H, Tong W, Ngai T, Qin L. Biosynthesized bandages carrying magnesium oxide nanoparticles induce cortical bone formation by modulating endogenous periosteal cells. ACS Nano, 2022.
Yao Z, Yuan W, Xu J, Tong W, Mi J, Chow H, Ho P, Li Y, Yao H, Li X, Xu S, Guo J, Zhu Q, Bian L, Qin L. Magnesium‐encapsulated injectable hydrogel and 3D‐engineered polycaprolactone conduit facilitate peripheral nerve regeneration. Advanced Science, 2022: 2202102.
Pang Q, Xu Y, Huang L, Li Y, Lin Y, Hou Y, Hung V, Qi X, Ni X, Li M, Jiang Y, Wang O, Xing X, Qin L, Xia W. Bone geometry, density, microstructure and biomechanical properties in the distal tibia in patients with primary hypertrophic osteoarthropathy assessed by second-generation HR-pQCT. Journal of Bone and Mineral Research, 2022, 37(3): 484-493.
Dai B, Xu J, Li X, Huang L, Hopkins C, Wang H, Yao H, Mi J, Zheng L, Wang J, Tong W, Chow H, He X, Li Y, He X, Hu P, Chen Z, Zu H, Li Y, Yao Y, Jiang Q, Qin L. Macrophages in epididymal adipose tissue secrete osteopontin to regulate bone homeostasis. Nature Communication, 2022, 13(1): 1-17.
Mi J, Xu J, Yao Z, Yao H, Li Y, He X, Dai B, Zou L, Tong W, Zhang X, Hu P, Ruan Y, Tang N, Guo X, Zhao J, He J, Qin L. Implantable electrical stimulation at dorsal root ganglions accelerates osteoporotic fracture healing via calcitonin gene-related peptide. Advance Science, 2022, 9(1): 2103005.
Mi J, Xu J, Yao H, Li X, Tong W, Li Y, Dai B, He X, Chow D, Li G, Lui K, Zhao J, Qin L. Calcitonin gene-related peptide enhances distraction osteogenesis by increasing angiogenesis. Tissue Engineering Part A, 2021, 27(1-2): 87-102.
He X, Li Y, Guo J, Xu J, Zu H, Huang L, Ong M, Yung S, Qin L. Biomaterials developed for facilitating healing outcome after anterior cruciate ligament reconstruction: Efficacy, surgical protocols, and assessments using preclinical animal models. Biomaterials, 2020: 120625.
Zu H, Chau K, Pan L, Dreyer C, Chow D, Huang L, Zheng L, Tong W, Li X, Chen Z, He X, Zhang R, Mi J, Li Y, Dai B, Wang J, Xu J, Liu K, Lu J, Qin L. Comparison of modified injection molding and conventional machining in biodegradable behavior of perforated cannulated magnesium hip stent. Journal of Materials Science & Technology, 2021. 021, 63: 145-160.
Xu J, Wang J, Chen X, Li Y, Mi J, Qin L. The effects of calcitonin gene-related peptide on bone homeostasis and regeneration. Current Osteoporosis Reports, 2020, 18(6): 621-632.
Pan Q, Li Y, Xu J, Kang Y, Li Y, Wang B, Yang P, Lin S, Li G. The effects of tubular structure on biomaterial aided bone regeneration in distraction osteogenesis. Journal of Orthopaedic Translation,2020, 25: 80-86.
Li L, Zhang M, Li Y, Zhao J, Qin L, Lai Y. Corrosion and biocompatibility improvement of magnesium-based alloys as bone implant materials: A review. Regenerative Biomaterials, 2017, 4(2): 129-137.
Ma R, Lai Y, Li L, Tan H, Wang J, Li Y, Tang T, Qin L. Bacterial inhibition potential of 3D rapid-prototyped magnesium-based porous composite scaffolds – An in vitro efficacy study. Scientific Reports, 2015, 5: 13775.
Cao HJ, Zheng LZ, Wang N, Wang L, Li Y, Li D, Lai Y, Wang X, Qin L. Src blockage by siRNA inhibits VEGF-induced vascular hyperpermeability and osteoclast activity – An in vitro mechanism study for preventing destructive repair of osteonecrosis. Bone, 2015, 74: 58-68.