研究助理教授
- BC516
- 2766 4196
- pearl.chen@polyu.edu.hk
- 脑神经科学和神经康复
ORCID ID
SCOPUS ID简历
陈璐华博士在香港攻读研究生课程之前，曾在中山大学附属医院接受临床培训并执业。她过往的临床培训经验激發了她对神经精神障碍性疾病研究（从早期神经發育到晚期神经退行性变等）的兴趣和热情。在香港大学李嘉诚医学院取得博士学位以后，她分别在香港大学和香港中文大学的心理学系接受了临床神经科学的博士后培训。
目前，陈博士的研究兴趣旨在了解遗传风险因素、环境风险因素和遗传-环境相互作用如何导致神经精神疾病和相关行为／特徵的發生、發展和／或恶化。她使用系统科学的方法，再结合先进的跨学科分析手段，将多层次的信息和多学科的理论有机结合起来，以促进我们对人脑认知功能的理解。此外，她的研究兴趣还包括鉴别认知功能的临床表型以进行早期疾病诊断，并揭示社会和文化相关的风险因素。她的最终研究目标是将研究成果转化为早期临床干预措施，以帮助认知功能受损的患者。
研究兴趣
研究成果
- Ma SL, Chen LH*, Lee CC, Lai K, Hung SF, Tang CP, Ho TP, Shea C, Mo F, Mak TSH, Sham PC, Leung PWL. Genetic overlap between attention deficit/hyperactivity disorder and autism spectrum disorder in SHANK2 gene. Frontier in Neuroscience (Section Neurogenomics), 2021, 27(15): 649588. (*Co-first author)
- Chen LH, Mak TSH, Fan YH, Ho DTY, Sham PC, Chu LW, Song YQ. Associations between CLU polymorphisms and memory performance: The role of serum lipids in Alzheimer’s disease. Journal of Psychiatric Research, 2020, 29(129): 281-288.
- Chen LH, Chu LW, Song YQ. Interlinking polymorphisms, estrogens and Alzheimer’s disease. In C Martin and V Preedy (Eds.), The neuroscience of dementia: Genetics, neurology, behavior and diet (pp. 25-39). Amsterdam, Netherlands: Elsevier, 2020.
- Li X, Wang J, Zhang R, Chen LH, Wang C, Ke J, Wang Y, Zhang Z. Psychological status and infection transmission conditions among anesthesiologists and operating room nurses during the outbreak period of COVID-19 in Wuhan, China. Frontiers in Psychiatry, 2020, 11: 574143.
- Shao L, Pan S, Zhang QP, Jamal M, Chen LH, Yin Q, Wu YJ, Xiong J, Xiao RJ, Kwong YL, Zhou FL, Lie AKW. A nonredundant role of innate lymphoid cells in the pathophysiology of graft-versus-host disease. Frontiers in Immunology, 2019, 6(10): 1233-1243.
- Yiend J, André J, Smith L, Chen LH, Toulopoulou T, Chen EYH, Sham PC, Parkinson B. Biased cognition in Eastern and Western cultures. PLoS One, 2019, 14(10): e0223358.
- Wang BB, Bao SY, Zhang ZG, Zhou XY, Wang J, Fan YH, Zhang Y, Li Y, Chen LH, Jia YZ, Li J, Li MX, Zheng WH, Mu N, Wang LQ, Yu Z, Wong DSM, Zhang YL, Kwan J, Mak HKF, Ambalavanan A, Zhou SR, Cai WW, Rouleau GA, Yang WL, Rogaeva E, Ma X, George-Hyslop PS, Chu LW, Song YQ. A rare variant in MLKL confers susceptibility to ApoE ɛ4-negative Alzheimer’s disease in Hong Kong Chinese population. Neurobiology of Aging, 2018, 68: 160.e1-7.
- Chan MH, Leung PW, Ho TP, Hung SF, Lee CC, Tang CP, Cheung SK, Ching FY, Chan F, Chen LH, Garcia-Barcelo M, Sham PC. Are psychiatric comorbidities and associated cognitive functions related to treatment response to methylphenidate in boys with attention-deficit/hyperactivity disorder? Neuropsychiatric Disease and Treatment, 2017, 11(13): 1071-1080.
- Leung PW, Chan JK, Chen LH, Lee CC, Hung SF, Ho TP, Tang CP, Moyzis RK, Swanson JM. Family-based association study of DRD4 gene in methylphenidate-responded attention deficit/hyperactivity disorder. PLoS One, 2017, 12(3): e0173748.
- Chen LH, Kao PY, Fan YH, Ho DT, Ha JC, Chu LW, Song YQ. The genetic polymorphisms in estrogen metabolic pathway associated with risks of Alzheimer’s disease: Evidence from a southern Chinese population. Journal of the American Geriatrics Society, 2017, 65(2): 332-339.
- Chen LH, Kao PY, Fan YH, Ho DT, Chan CS, Yik PY, Ha JC, Chu LW, Song YQ. Polymorphisms of CR1, CLU and PICALM confer susceptibility of Alzheimer’s disease in a southern Chinese population. Neurobiology of Aging, 2012, 33(1): 210.e1-7.
- Zhou L, Chan KH, Chu LW, Kwan JS, Song YQ, Chen LH, Ho PW, Cheng OY, Ho JW, Lam KS. Plasma Amyloid-β oligomer level is a biomarker for Alzheimer’s disease diagnosis. Biochemical and Biophysical Research Communications, 2012, 423(4): 697-702.
