Gaussian curvature-driven direction of cell fate towards osteogenesis with triply periodic minimal surface scaffolds
To utilize the advantage of the architectural marvel of the hyperboloid structure, a novel three-dimensional (3D) Triply Periodic Minimal Surface (TPMS) scaffolds with varying Gaussian curvatures is developed to embody a trabecular bone mimicking hyperboloidal topography. The wavy TPMS scaffolds direct the osteogenic differentiation and angiogenic paracrine of mesenchymal stem cells through the hyperboloidal topography-induced cytoskeleton reorganization and nuclear deformation, accelerating the bone regeneration. The TPMS bone scaffolds can get a head start towards a simple, safe, efficient and personalized bone graft with notable clinical translation potential.
![Gaussian curvature-driven direction of cell fate](/rio/-/media/department/rio/content/for-partner/technology-showcase/life-sciences-n-healthcare/gaussian-curvature-driven-direction-of-cell-fate.jpg?bc=ffffff&h=400&w=685&hash=C0C1EE6F49AFDA2CF3F93D980B49895E)