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Dr Samantha SHAN

Dr Samantha SHAN
BSc, MPhil, PhD
Research Assistant Professor

➲ ORCiD 0000-0001-6876-9914
➲ Author ID (Scopus) 57203255069

Biographical Sketch

Dr Samantha SW Shan obtained her Bachelor’s degree in Biochemistry from The Chinese University of Hong Kong (CUHK). After completing her undergraduate studies, she obtained her PhD degree in the Department of Anatomy in CUHK (which is now under the School of Biomedical Science). Following this, she spent about four years as a Postdoctoral Fellow in the Sunnybrook Health Science Centre, an affiliated hospital of University of Toronto, Canada, where she was involved in microRNA studies associated with hepatocellular carcinoma in microRNA-transgenic mice. Her work was very well received in conference presentations and resulted in a number of publications in high impact journals, including Nature Cell Biology, FASEB Journal and the Journal of Cell Science. Prior to joining The Hong Kong Polytechnic University, she has worked as a laboratory director in a private cord blood bank in Hong Kong for three years. Dr Shan joined School of Optometry as a Research Fellow in 2014 and is currently a Research Assistant Professor in the School.

Dr Shan has more than ten year’s local and overseas experience in molecular research. She is proficient in adopting both genomic and proteomic approaches in her work. Dr Shan’s research interest is the pathophysiology of glaucoma. Her research is attempting to unravel the mechanisms of aqueous humor secretion, outflow facility, and intraocular pressure (IOP). Her research associated with ocular health has been published in international journals including Investigative Ophthalmology and Vision Science, Scientific Reports, Journal of Proteomics, J. Proteome Research and Oxidative Medicine and Cellular Longevity.

Selected Publications

Abokyi S, Shan SW, To CH, Chan HH, Tse DY. Autophagy Upregulation by the TFEB Inducer Trehalose Protects against Oxidative Damage and Cell Death Associated with NRF2 Inhibition in Human RPE Cells. Oxid Med Cell Longev. 2020; 2020:5296341.
SW Shan, Chi-Wai Do, Thomas Chuen Lam, Hoi-Lam Li, W Daniel Stamer, Chi-Ho To. Data on Differentially Expressed Proteins in Rock Inhibitor-Treated Human Trabecular Meshwork Cells Using SWATH-based Proteomics. Data in Brief. 2020; 31:105846.
Li KK, Shan SW, Li HL, Cheng AKW, Pan F, Yip SP, Civan MM, To CH, Do CW. Characterization and Regulation of Gap Junctions in Porcine Ciliary Epithelium. Invest Ophthalmol Vis Sci. 2018; 59 (8): 3461-3468.
Shan SW, Tse DY, Zuo B, To CH, Liu Q, McFadden SA, Chun RK, Bian J, Li KK, Lam TC. Integrated SWATH-based and targeted-based proteomics provide insights into the retinal emmetropization process in guinea pig. J Proteomics. 2018; 181:1-15.
Shan SW, Do CW, Lam TC, Kong RPW, Li KK, Chun KM, Stamer WD, To CH. New insight of common regulatory pathways in human trabecular meshwork cells in response to dexamethasone and prednisolone using an integrated quantitative proteomics: SWATH and MRM-HR mass spectrometry. J. Proteome Research 2017; 16(10):3753-3765.

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