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Mr. Chunghim SO | Mr. Dong LIANG | Mr. Milan RAI | Ms. Jing ZHANG | Ms. Shuwen JIA | Ms. Wing Yan LAU | Ms. Yingkun CUI | Ms Jingfang Jennifer BIAN | Mr Shashi Kant CHAUDHARY | Ms Meng CHENG | Mr Ka Wai Jimmy CHEUNG | Ms Hang I Christie LAM | Ms Hoi Lam LI | Ms Sonal Aswin VYAS | Mr Kin Ken WAN | Ms Biyue GUO | Ms Li PAN | Ms Qi TAN | Mr Mezbah UDDIN | Ms Rong LI | Ms. Yuanyuan LIANG | Ms Anqi LYU | Mr Ying Hon SZE | Ms Qin WANG | Ms Hanyu ZHANG | Ms Wei YANG | Ms Mei ZHAO | Ms Yajing YANG | Ms Fangyu XU | Mr Sung Hei Jimmy TSE | Ms. Seen Hang CHAN | Mr. CHAN Kin Ho | Ms. AYERAKWAH Patience Ansomah | Mr. SO Ching | Mr. CATRAL Kirk Patrick Carreon | Mr. LIU Zhengji | Mr. LU Daqian | Ms. QIU Chunting | Mr. YANG Xiayin
About us > Our People > Research Students > Mr. LU Daqian
Mr. LU Daqian
Mr. LU Daqian
PhD Student
➲ ORCiD 0000-0003-2804-2424
Title of project:
Atropine mediated proteomic changes in myopia control: Insights from a
mammalian guinea pig model
Synopsis:
The molecular mechanism underlying atropine in controlling myopia is still elusive and controversial, limiting the clinical application of atropine to a large extent. Given the escalating social and economic burden associated with myopia, it urgently entails to studying the molecular mechanism of atropine in controlling myopia to develop more targeted therapies that could improve the efficacy and reduce short-term or long-term side effects. Next-generation proteomics technology now allows thousands of proteins and their post-translational modifications at tissue levels to be quantified more efficiently and accurately than ever before.
The project aims to apply sensitive and high throughput proteomics to unravel temporal events of atropine-related myopia control pathways and to further understand the mechanism of the popular atropine dosages in controlling myopic progression. Expressions of identified protein targets will be further confirmed by immunohistochemistry and a novel targeted multiple reaction monitoring (MRM) approach after bioinformatics analysis. Upon completion of this project, we will identify the most significant targets, their associated cascades, and sites of therapeutic action involved in the atropine-mediated myopia control from the retina to the sclera at temporal manner. Due to the known toxicity of atropine, our discovery may uncover off targets to give better insight for novel and key molecular targets for further development of effective agents in myopia control.
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