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About us > Our People > Research Students > Mr. YANG Xiayin
Mr. YANG Xiayin
Mr. YANG Xiayin
PhD Student
➲ ORCiD 0000-0002-5229-3509
Title of project:
Longitudinal assessment of optic nerve neurodegeneration using rodent models of
demyelinating optic neuritis
Synopsis:
Demyelinating optic neuritis is an inflammatory condition on optic nerves and
common in East Asian populations. It happens in different pathological
conditions, for example, neuromyelitis optica spectrum disorder or multiple
sclerosis. The current immunosuppressive therapies cannot provide a good visual
outcome in a part of patients with demyelinating optic neuritis. Consequently, it
may result in irreversible impairment of vision. The pathophysiology of demyelinating
optic neuritis still remains unclear currently. The laboratory and clinical investigations
of this disease in Asian populations, and especially in Chinese people, are needed.
In this project, we try to have a better understanding and observation in development of demyelinating optic neuritis based on the novel rodent models, and monitor the longitudinal structural changes in axonal injury in demyelinating optic neuritis using optical coherence tomography and electrophysiological techniques. This study will provide an ideal platform for follow-up studies on the characteristics, pathogenesis and new therapeutic development in relation to optic neuritis.
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