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Dr Thomas LAM

Dr Thomas LAM
BSc PhD
Associate Professor

➲ ORCiD 0000-0002-3511-5620
➲ Author ID (Scopus) 23009006200

Biographical Sketch

Dr Thomas Lam completed his undergraduate training with first class honours in Optometry from PolyU. He was awarded a PhD scholarship to pursue his study on proteomics and animal myopia. He is among the first to pursue global retinal protein profiling and novel protein regulations in the chick myopia model using a mass spectrometry approach. Dr Lam started his academic career in 2008 as a Lecturer in the School of Optometry in PolyU and obtained his first competitive research grant from the RGC in the following year. In 2010, he relocated to Singapore and helped establish the first BSc Optometry degree programme offered by the University of Manchester (UK). He returned to Hong Kong in 2012 and he is currently an Associate Professor of the School of Optometry.

Dr Lam has a good mix of academic and clinical experience. He obtained his fellowship of American Academy of Optometry (FAAO) in 2009. He has more than 10 years’ experience in clinical supervision in various optometry clinics locally and overseas. He also actively serves in the profession as an editorial board member of international journals, an organizing committee member of international conferences, a councilor of The Hong Kong Society of Professional Optometrists (HKSPO), and a member of The Optometrists Board. His novel application of proteomics in eye research has attracted a number of collaborative research and equipment grants from the University Grants Committee of HKSAR, PolyU, and mainland China. In order to further expand the depth and breadth of proteomics applications in eye research, his group is applying next-generation data-independent mass spectrometry and targeted proteomics to study multifactorial eye diseases and disorders including myopia, glaucoma, and altered tear proteome.

Selected Publications

Shan SW, Tse DY, Zuo B, To CH, Liu Q, McFadden SA, Chun RK, Bian J, Li KK, and Lam TC, “Integrated SWATH-based and targeted-based proteomics provide insights into the retinal emmetropization process in guinea pig”, Journal of Proteomics. 181 (2018) 1-15
Chun RK, Shan SW, Lam TC, Wong CL, Li KK, Do CW, To CH. Cyclic Adenosine Monophosphate Activates Retinal Apolipoprotein A1 Expression and Inhibits Myopic Eye Growth. Invest Ophthalmol Vis Sci. 2015;56(13):8151-7.
Yu FJ, Lam TC, Liu LQ, Chun RK, Cheung JK, Li KK, To CH, Isotope-coded protein label based quantitative proteomic analysis reveals significant up-regulation of apolipoprotein A1 and ovotransferrin in the myopic chick vitreous. Sci Rep 2017, 7, (1), 12649.
Shan SW, Do CW, Lam TC, Kong RPW, Li KK, Chun KM, Stamer WD, To CH, New insight of common regulatory pathways in human trabecular meshwork cells in response to dexamethasone and prednisolone using an integrated quantitative proteomics: SWATH and MRM-HR mass spectrometry. J Proteome Res 2017, 16, (10), 3753-3765.

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