Ms. QIU Chunting
PhD Student
➲ ORCiD 0000-0001-8822-767X
Title of project:
Low doses of atropine effects on firing patterns of retinal ganglion cells
Synopsis:
Myopia (near-sightedness) is the most common eye disorder and the leading cause
of visual disability in the world. Low-dose atropine is common in
pharmacological options for myopia. Atropine has been shown to have a positive
effect in reducing the elongation of axial length in myopic eyes, but the exact
mechanism of the suppressive effect of atropine is unknown.
The retinal ganglion cell is a type of neuron located near the inner surface
(the ganglion cell layer) of the retina of the eye, forming numerous parallel
visual channels which deliver substantially different transforms of visual
information to the various central targets they innervate.
Our aim is to examine how the low-dose atropine affects the temporal firing
characteristics of populations of RGCs and how the low-dose atropine affects
the firing patterns of populations of RGCs with focused/defocused images. Such
change in the population of RGC activities may serve as an early step in myopia
development in the retina.
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