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PolyU researchers develop novel selenium nanoparticles for managing postmenopausal osteoporosis

As the aging population around the world grows, metabolic diseases like osteoporosis are becoming more prevalent and placing a greater burden on healthcare systems. Rising to this challenge, a research team led by Prof. WONG Ka-hing, Director of the Research Institute for Future Food and Professor of the Department of Food Science and Nutrition at The Hong Kong Polytechnic University (PolyU), has developed novel selenium nanoparticles (Cs4-SeNPs) for managing postmenopausal osteoporosis. The latest research findings were recently published in Journal of Functional Foods. This patented nanotechnology has also gained wide recognition, leading to various national and international awards, including the Ministry of Education’s Higher Education Outstanding Scientific Research Output Awards (Science and Technology) 2020: Second-Class Award in Technological Innovation. Selenium (Se) is an essential trace mineral for human health, playing important roles in many physiological functions. In the past decades, substantial evidence has demonstrated that Se deficiency is detrimental to bone microarchitecture and is associated with osteoporosis, suggesting its crucial role in bone metabolism. Recently, selenium nanoparticles (SeNPs) have become a new target of research, since they were found to possess remarkable bioactivity and lower toxicity compared to selenocompounds commonly found in foods. However, scientific research concerning their effects on bone health is currently very limited. Cordyceps sinensis (Berk.) Sacc. is a medicinal fungus which has been long used as a tonic and therapeutic agent. By using polysaccharide–protein complexes (PSPs) isolated from the C. sinensis mycelium (Cs4) and a previously patented nanotechnology, the research team has recently prepared novel selenium nanoparticles with a uniform structure and high stability (Cs4-SeNPs). In experiments using pre-osteoblast murine MC3T3-E1 cells, the research team demonstrated that Cs4-SeNPs were taken up rapidly and efficiently by the cells. Treatment with Cs4-SeNPs (10µM) increased proliferation of the MC3T3-E1 cells and promoted their differentiation to mature osteoblasts. Enhancement of bone mineralization of the MC3T3-E1 cells was also observed, indicating the promoting effect of Cs4-SeNPs on new bone formation. Further investigation of their action mechanism revealed that Cs4-SeNPs induced the production of physiological levels of reactive oxygen species to trigger osteoblast differentiation. Interestingly, comparison of these effects with those of common selenocompounds found that only Cs4-SeNPs showed significant osteogenic activity, and it was less toxic to the cells. More importantly, Cs4-SeNPs (25-500μg/kg BW/day) exhibited promising in vivo bone protective efficacy against OVX-induced osteoporosis by promoting bone formation, inhibiting bone resorption, and improving bone microarchitecture after oral gavage for 6 weeks. The team is currently working with local industry partners to bring the resulting health food products to market. Prof. Wong said, “The novel nano-mineral Cs4-SeNPs has a wide spectrum of health promotion and disease prevention applications, not just for postmenopausal osteoporosis management. Apart from developing a high-quality, safe and evidence-based bone protective agent to improve the quality of life of postmenopausal osteoporosis patients, our team is now investigating the effects of Cs4-SeNPs on treating Parkinson’s disease and more. We hope to tap into its potential biomedical value through interdisciplinary collaboration, thus further promoting research and applications in related fields.”   ***END***

15 Nov, 2023

Research Institute for Future Food

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PolyU joins hands with Hangzhou and Wenzhou in Zhejiang Province to build innovation platforms for advancing technologies and cultural tourism

The Hong Kong Polytechnic University (PolyU) has teamed up with Hangzhou and Wenzhou, two major cities in Zhejiang Province, to build innovation platforms for advanced technology and innovation, as well as cultural tourism, with a view to deepening their collaborations with Hong Kong. The signing and unveiling ceremony of the PolyU-Wenzhou Technology and Innovation Research Institute (the Institute) was held at the Wenzhou People’s Congress Hall on 9 November, marking the official landing of the Institute in Wenzhou. The Institute strives to foster technological innovation, talent cultivation, and research and development (R&D), developing Wenzhou into an innovation and technology (I&T) hub. Separately, PolyU signed agreements with the Wenzhou Municipal People’s Government and the Administration Committee of Wenzhou Bay New Area. Witnessed by Dr LAM Tai-fai, Council Chairman of PolyU; Mr ZHANG Zhenfeng, Secretary of Wenzhou Municipal Party Committee; Mr GE Yiping, Director of the Standing Committee of Wenzhou Municipal People’s Congress; and Mr CHEN Zuorong, Chairman of the Wenzhou Municipal People’s Political Consultative Conference, the agreement at the municipal level was signed by Prof. Jin-Guang TENG, President of PolyU and Mr WANG Zhenyong, Vice-Mayor of Wenzhou Municipal People’s Government; while at district level it was signed by Prof. Christopher CHAO, Vice President (Research and Innovation) of PolyU and Mr ZHOU Yi-fu, Secretary of the Longwan District Committee of Wenzhou Municipal People’s Government. PolyU is the first university in Hong Kong to collaborate with Wenzhou Municipal People’s Government in setting up a technology and innovation research institute in Wenzhou. The Institute aims to promote I&T development in the Southeastern coastal region, in response to the industrial development needs of Wenzhou and Zhejiang Province specifically, and the Nation more broadly. The Institute will engage in close collaborations with local key industries in the areas of marine engineering equipment and technology, flexible electronics, and ultra-precision manufacturing to advance their core technologies, outcome transformation, talent development, and innovation and entrepreneurship, promoting the high-quality economic development of the cites. In his speech, Dr LAM Tai-fai emphasised that PolyU values research and innovation, actively promoting the transformation of research outcomes into practical applications, and believes the joint establishment of the Institute holds great promise. With its strong research capabilities and a pool of world-class scholars, the University provides a solid foundation for deep collaboration between Hong Kong and Wenzhou, which has a thriving private economy with a solid industrial foundation with hardworking and innovative talents. PolyU will further leverage its advantages in talents, academia, research, and internationalisation, while captalising on Wenzhou’s industrial clusters, innovation, talent cultivation, and R&D services to explore new methods, concepts, and perspectives in research for accelerating the transformation and application of research achievements as well as driving industrial upgrading. This innovation platform will serve as an opportunity to strengthen cooperation with various stakeholders in Wenzhou in terms of talent attraction, innovation ecosystem, cultural inheritance and exchange, making greater contributions to high-quality regional development. Mr ZHANG Zhenfeng stated that innovation is in Wenzhou’s genes. In recent years, Wenzhou has always kept in mind the earnest instructions from General Secretary of the Chinese Communist Party Xi Jinping to continue writing the history of innovation. Wenzhou is determined to take the path of innovation-driven development by enhancing its capabilities for innovation, developing strategic innovation platforms and introducing university-industry research collaboration platforms. The cooperation with PolyU is perfectly timed, at the right place and with the right people. The Institute will become a powerful engine to develop Wenzhou into a nationally innovative city, a new force in fostering two industrial clusters with output valued at the trillion-yuan level, and a bridge to connect to global innovation resources. It will help enhance Wenzhou’s competitiveness in technological innovation, shape new trends in industrial development, and attract innovative international talents. Wenzhou will do its best to provide efficient services to ensure the smooth operation and development of the Institute. The PolyU delegation not only introduced the Institute’s development plan and presented a research showcase of the latest technology achievements for local enterprises, but also made visits to local universities. Moving forward, the two parties will stive to strengthen cooperation in technology, as well as promote academic and cultural exchanges between Wenzhou and Hong Kong to achieve a win-win outcome. Previously, the PolyU-Hangzhou Technology and Innovation Research Institute was also officially launched with a signing and unveiling ceremony on 7 November, in Hangzhou. The Institute aspires to promote advanced technology in the fields of Grand Canal culture and tourism, intelligent transportation and medical aesthetics, and will initially establish three research centres, namely the Grand Canal Culture and Tourism Research Center, Intelligent Rail Transit Center, and Digital Medical Aesthetics Research Center. These centres will collaborate with Hangzhou’s key industries and university research institutes in information technology and internet, cultural tourism, smart cities, biomedicine, and high-end equipment manufacturing, providing exchange platforms for researchers, technology innovation services for local enterprises, as well as application scenarios for cutting-edge PolyU technologies. Identified as one of the important provinces for national panning, Zhejiang province has been committed to promoting the coordinated development of education, technology and the economy. The establishment of the two new research institutes aims to build closer ties between Hong Kong and the two cities, bringing together innovative talents and resources. It also seeks to strengthen industry-university research collaborations and connect local industries with international markets, so as to develop Zhejiang into a dynamic and innovation-driven hub and make a meaningful contribution to the Nation’s technological innovation and cultural tourism development.   ***END***

14 Nov, 2023

Research and Innovation Office

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PolyU research project on climate-resilient coastal infrastructure supported by French National Research Agency/RGC Joint Research Scheme

Climate change is one of the most pressing issues facing the world. The Hong Kong Polytechnic University (PolyU) has received support from The French National Research Agency (Agence Nationale de la Recherche)/Research Grants Council Joint Research Scheme (ANR/RGC Joint Research Scheme) - 2023/24 Exercise to conduct an innovative project on enhancing the resilience of coastal infrastructure to mitigate climate change risks such as sea-level rise and storm surges. It is one of three projects awarded funding from among Hong Kong institutions. Global warming is seen to be leading to more frequent occurrences of extreme weather. In the face of this challenge, the project “Smart and Flexible Climate Change Adaptation of Coastal Infrastructure”, led by Dr You DONG , Associate Professor of Department of Civil and Environmental Engineering of PolyU, has been granted HK$2.45 million under the ANR/RGC Joint Research Scheme for a period of 48 months. The project is being undertaken in collaboration with Prof. Edgar Emilio Bastidas Arteaga of La Rochelle University in France. Prof. Christina WONG, PolyU Director of Research and Innovation, said, “As an innovative world-class university excelling in diverse disciplines, PolyU has established extensive global partnerships for academic and research collaboration. With a mission to address complex global issues and tackle scientific challenges, we will continue to work closely with our partners to leverage our research strengths, drive innovation across a broad spectrum of cutting-edge research initiatives, and achieve a lasting global impact.” The funded project will focus on robust and intelligent adaptation of high-risk coastal building structures in Hong Kong and France to withstand compounded coastal flooding and sea level rise caused by global warming, storm surges resulting from tropical cyclones, and heavy rainfall. The intensity and frequency of these events are expected to increase due to climate change. A physics-informed data-driven approach is proposed to predict the occurrence and intensity of future flood hazards. Fluid-structure-interaction models will be developed to explore flood-related damage and failure mechanisms of coastal buildings in a life-cycle context. In addition, physics-guided deep learning will be utilised to develop multivariate vulnerability and risk models that focus on different building archetypes in the area under investigation and to form a framework for community-level vulnerability and resilience assessment. The research results are expected to generate technologies and knowledge that will contribute to the upgrading of climate-resilient infrastructure in Hong Kong and globally in the near-future. The ANR/RGC Joint Research Scheme aims to strengthen collaboration between French and Hong Kong research communities, and both basic and applied research proposals of high academic merit in all areas are invited under the Scheme. The assessment criteria include technical and scientific quality, quality of project management and methodology, global impact and the quality of synergies between the partners.   ***END***

13 Nov, 2023

Research and Innovation Office

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PolyU-Hangzhou Technology and Innovation Research Institute officially unveiled, deepening industry-academia-research collaboration

The Hong Kong Polytechnic University (PolyU) and the Hangzhou Gongshu People’s Government held a signing cum unveiling ceremony on 7 November in Hangzhou, marking the official establishment of the PolyU-Hangzhou Technology and Innovation Research Institute (the Institute). In order to promote Hangzhou’s innovation and technology development, the Institute will conduct collaborative in-depth industry-academia-research, leveraging the advantages of Hangzhou and Hong Kong in research innovation, smart cities, as well as industrial and international cooperation and innovation. The Institute will focus on key areas including Grand Canal culture and tourism, intelligent transportation and medical aesthetics, and will initially establish three research centres, namely the Grand Canal Culture and Tourism Research Center”, Intelligent Rail Transit Center, and Digital Medical Aesthetics Research Center. These centres will collaborate with Hangzhou’s key industries and university research institutes in the areas of information and internet technology, cultural tourism, smart cities, biomedicine and high-end equipment manufacturing, providing enterprises with a technological research and development service, striving to make Hangzhou a world-class smart digital and innovative city, and the world’s best city to visit. Witnessed by Dr LAM Tai-fai, Council Chairman of PolyU; Prof. Jin-Guang TENG, President; Prof. DONG Cheng, Associate Vice President (Mainland Research Advancement); Prof. NI Yiqing, Professor of Smart Structures and Rail Transit of the Department of Civil and Environmental Engineering, as well as Mr ZHOU Hong, Zhejiang Representative of the Hong Kong Trade Development Council; Mr FANG Yi, Member of the Standing Committee of the CPC Hangzhou Municipal Committee, Member of the Leading Party Members' Group of Hangzhou Municipal Government, Deputy Mayor of Hangzhou; Mr LI Zhilong, Communist Party Secretary of Gongshu District; Mr LU Wenge, Level II Bureau Rank Official of the Department of Science and Technology of Zhejiang Province; Mr LOU Xiuhua, Director of the Hangzhou Municipal Science and Technology Bureau, and Mr HUANG Fei, Member of the Standing Committee and Executive Deputy District Mayor of the Gongshu District, the agreement was signed by Prof. Christopher CHAO, Vice President (Research and Innovation) of PolyU, and Mr SHEN Jianli, Vice District Mayor of Gongshu District. Dr Lam Tai-fai stated in his speech that Hangzhou is a city that integrates tradition with innovation. As a globally top-ranked institution with 86 years of history, PolyU will fully leverage its strengths in research, education and talent development to accelerate the industrial development of Hangzhou in the fields of Grand Canal culture and tourism, intelligent transportation and medical aesthetics, with a view to promoting technological innovation and facilitating the transformation of research outcomes to make greater contributions to the high-quality development of Gongshu district, Hangzhou and the Nation. In his speech, Mr Li Zhilong said that Hangzhou strives to capitalise on its advantages in technological innovation to promote urban development. The city is actively developing itself as a global innovation hub, talent pool and prioritised destination for technology transfer and commercialisation. Gongshu District will fully utilise its geographical location and resources, and environmental benefits to create a favourable environment for technological innovation. The government-academia collaboration with PolyU will definitely increase synergies between Hangzhou and Hong Kong to enhance the competitiveness of technological innovation and pave a new way for advancement. With its solid industrial foundation, Hangzhou has a sound innovation and entrepreneurship environment in the areas of internet technology, the digital economy and artificial intelligence. Going forward, PolyU will leverage its strengths in interdisciplinary studies, talent cultivation, research and innovation, and international cooperation to accelerate the sustainable development of Hangzhou and facilitate talent exchange between the two regions through the Institute’s innovation and technology platform.

9 Nov, 2023

Research and Innovation Office

PolyU research seizes BOCHK Science and Technology Innovation Prize 2023

The Hong Kong Polytechnic University (PolyU) research has been honoured with the Bank of China (Hong Kong) Limited (BOCHK) Science and Technology Innovation Prize 2023 (STIP) for its exceptional accomplishments in the fields of “Advanced Manufacturing” and “FinTech”. Since the inception of this prestigious award last year, PolyU has reinforced its position as the leading institution in Hong Kong, securing a total of four awards. Prof. Jin-Guang Teng, PolyU President, congratulated the three laureates and said, “PolyU takes pride in being home to such a distinguished group of scholars. These exceptionally talented researchers are driven by their passion for scientific breakthroughs and innovation. They strive to develop cutting-edge technologies and make ground-breaking discoveries that contribute to the betterment of the community, and which will have a lasting impact on the world. PolyU remains committed to supporting its researchers in their pursuit of research that not only benefits Hong Kong, but also the country and the world.” The three award-winning PolyU scholars: Prof. CHEUNG Chi Fai Benny, Chair Professor of Ultra-precision Machining and Metrology of the Department of Industrial and Systems Engineering and Director of the State Key Laboratory of Ultra-precision Machining Technology (The Hong Kong Polytechnic University), is recognised in the “Advanced Manufacturing” field. His pioneering ultra-precision nano multi-ring machining technology has successfully been applied in the research and development of a novel and high-efficacy nano multi-ring defocus incorporated spectacle lens for myopia control, which has the potential to benefit myopic schoolchildren globally. A novel magnetic field-assisted batch superfinishing technology and equipment have also been developed for mass superfinishing surgical tools that can reduce wound trauma during bio-medical applications. His innovative research on the next generation of in-situ precision three-dimensional surface metrology not only supports manufacturing of high-precision products but also can be used under various manufacturing or measurement scenarios in the context of Industry 4.0 to realise smart precision manufacturing. Prof. Cheung has made outstanding contributions with his innovative research into new methods, new processes and new equipment for ultra-precision machining, precision metrology and smart precision manufacturing. Prof. AU Man Ho Allen, Professor of the Department of Computing is recognised in the “FinTech” field. His ground-breaking research focuses on the design and analysis of privacy-enhancing and quantum-resistant cryptographic algorithms to address security, privacy and scalability needs in real-world blockchains. His research advances blockchain technology and spearheads the Web3 revolution through innovative approaches and transformative solutions, paving the way for secure, interoperable and scalable applications in the next generation of decentralised protocols and applications. Many of his inventions have been recognised and adopted by leading IT companies and blockchain platforms. Prof. Au’s recent research on zero-knowledge proof (ZKP) is noteworthy. ZKP is widely regarded as a breakthrough technology that enables data privacy protection, efficiency improvement and scalability of transparent systems such as blockchains. He developed innovative solutions that reduce the computation cost of ZKP. His team optimised ZKP using distributed computing and GPU acceleration, winning US$550,000 at ZPRIZE organised by the Web3 community. Prof. LUO Xiapu Daniel, Professor of the Department of Computing, is also recognised in the “FinTech” field. His innovative work in the field of cybersecurity has been instrumental in identifying and fixing security vulnerabilities and defending against cyber-attacks that pose significant risks to critical infrastructures, including blockchain systems, smart contracts, smartphones, IoT devices and automobiles. His research findings have been recognised by prominent blockchain platforms and leading IT companies. Prof. Luo’s research contributes to strengthening the robustness of blockchain technologies, advancing the security and privacy of mobile and IoT devices and enhancing network security measures. His work has led to ten best/distinguished paper awards, including the ACM SIGSOFT Distinguished Paper Award at ISSTA 2022, ACM SIGSOFT Distinguished Paper Award at ICSE 2021 and Best Paper Award at INFOCOM 2018, as well as several awards from industry. The STIP, established by the Hong Kong Alliance of Technology and Innovation and sponsored by BOCHK, is a non-governmental merit-based award. It aims at facilitating the development of science and technology innovation in Hong Kong by rewarding outstanding individuals and groups who have made significant contributions to science and technology innovation in Hong Kong. A cash prize of HK$2 million is awarded for each field. PolyU achieved remarkable success in last year’s STIP 2022 in the areas of “Advanced Manufacturing” and “Life and Health”, with the prestigious awards being bestowed upon Prof. WANG Zuankai, Associate Vice President (Research and Innovation) and Chair Professor of Nature-Inspired Engineering in the Department of Mechanical Engineering, and Prof. ZHENG Yongping, Henry G. Leong Professor in Biomedical Engineering, Chair Professor of Biomedical Engineering, and Director of Research Institute for Smart Ageing.   ***END***

7 Nov, 2023

Research and Innovation Office

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PolyU hosts Jockey Club Smart Ageing Hub Project Achievement Sharing Day Summarising the fruitful results of six years to promote the application of local gerontechnology

The Hong Kong Polytechnic University (PolyU) hosted the Jockey Club Smart Ageing Hub Project Achievement Sharing Day on 3 November 2023, aiming to share the fruitful achievements of the Project with stakeholders in the gerontechnology (gerontech) field. The event brought together cross-disciplinary experts to share their experience and best practices and to discuss the future development of Hong Kong’s gerontech ecosystem. The welcome ceremony was officiated by Mr Chris SUN, Secretary for Labour and Welfare of the Hong Kong Special Administrative Region, Mr Bryan WONG, Head of Charities (Positive Ageing & Elderly Care) of The Hong Kong Jockey Club and Dr Miranda LOU, PolyU Executive Vice President. The event was attended by more than 300 cross-disciplinary representatives from the gerontech field including stakeholders from the elderly care industry, academia, and the business sector. An HKSAR Chief Executive’s Community Project since December 2017, the Jockey Club Smart Ageing Hub received a donation of over HK$47 million from The Hong Kong Jockey Club Charities Trust and is currently managed by the PolyU Department of Biomedical Engineering. The Project aims to tackle issues related to Hong Kong’s ageing population through the establishment of a cross-disciplinary network, in order to promote not only innovative gerontech solutions for elderly care, but also to enhance quality of life for the elderly. In her welcome remarks, Dr Lou stated, “PolyU is not an academic silo, but rather an integral part of the Hong Kong community. Whether it is scientific research or knowledge transfer, we must ensure that we contribute to the well-being of Hong Kong citizens. As an international city with an ageing population, we believe that utilising PolyU’s knowledge and technology to address the societal needs of the elderly is the most appropriate strategy for us. The Jockey Club Smart Ageing Hub aims to advance gerontech in order to foster a smart and age-friendly community. A Day Experience Centre is located on the PolyU campus to provide information on gerontech for elderly people and caregivers, and six elderly care service and rehabilitation service units have been invited to join as strategic partners in the development of Real-life Hostels. These Hostels are equipped with gerontech to enhance the quality of life for service users, who include the elderly and aged individuals with disabilities. This initiative aims to promote the application of technology in the industry, ultimately optimising the continuum of care.” In his welcome remarks, Mr Wong stated that The Hong Kong Jockey Club is committed to supporting older people to age with dignity and respect, and working with different partners to improve the elderly’s quality of life. “The Jockey Club Smart Ageing Hub Project has made remarkable achievements. We are very grateful for the efforts of the PolyU team and all the organisations and volunteers involved in the project. As gerontech becomes popular, the next step is to enhance the application of these tools. In the next three years, the Club will continue to cooperate with PolyU to improve the services of residential care homes for the elderly through technology,” Mr Wong said. Enhancing quality of service for the elderly and disabled individuals with gerontech solutions To improve the continuum of care services for the elderly and individuals with disabilities, the Project aims to reinforce the application of gerontech tools based on the specific needs of each elderly person and disabled service units, and to facilitate on-site visits at the Real-life Hostels by elderly care industry representatives with a view to encouraging the industry to effectively leverage technology to improve service quality. Furthermore, innovative PolyU technology solutions have been implemented in multiple Real-life Hostels. These solutions include the eNightLog bed-leaving monitoring system for enhancing overnight residential services, the smart toilet sensing system to ensure the safety of the elderly during toileting, and a detachable laser indicator to assist older adults in gait training activities. These gerontech solutions have not only benefited 3,500 elderly and disabled individuals, but also alleviated the burden and pressure on frontline healthcare workers. At the same time, through the practical experience of applying gerontech in six Real-life Hostels, the industry has gained valuable reference and insights on the application of gerontech solutions. Promoting gerontech applications in the community The Project team has established a Day Experience Centre on the PolyU campus, showcasing over 2,000 gerontech tools collected from around the world and integrated them into a categorised resource library. They have also organised over 1,200 activities for public education on gerontech, including guided tours, workshops and exhibitions. To further enhance public awareness of gerontech in Hong Kong, the Project team regularly organises the “Health Care Day” to provide health assessments, encouraging the public to utilise technology for their own personal health management. They have also collaborated with 12 District Health Centres (DHC) and DHC Expresses to establish “Gerontech Corners” and co-organised 35 thematic exhibitions with over 500 gerontech and assistive devices on show. In addition, community outreach activities have been conducted in partnership with various organisations promoting the use of technology in preventing chronic diseases. The Project has invited around 60 elderly care units to participate in trial programme of the PolyU research achievement the Smart Companion Robot. In total, these various activities have benefited over 40,000 individuals in Hong Kong, contributing to the widespread application of gerontech. The Project team has made remarkable contributions to the promotion and development of gerontech, earning widespread societal recognition and garnering support from The Hong Kong Jockey Club Charities Trust. In the next three years, the Project team will continue to provide gerontech support to the community and work hand in hand with 11 self-financing residential care homes for the elderly operated by small-to-medium NGOs. This collaboration aims to create more intelligent residential care homes, furthering the advancement of the elderly care industry and the community in embracing gerontech in response to the challenges presented by an ageing population.   ***END***

7 Nov, 2023

Department of Biomedical Engineering

1a

PolyU-Wuxi Technology and Innovation Research Institute officially inaugurated Joining force with Mainland enterprises to cultivate industry-academia-research collaborations and propel I&T development in the Yangtze River Delta

The Hong Kong Polytechnic University (PolyU) and the Wuxi Municipal People’s Government of Jiangsu Province have jointly established the PolyU-Wuxi Technology and Innovation Research Institute (The Institute), and an Inauguration Ceremony cum Industry-University-Research Collaboration Agreement Signing Ceremony was held on 2 November. Located in Wuxi, the Institute serves as a platform to drive advanced research and innovation, as well as nurture innovation and technology (I&T) talents. It has entered into agreements with ten high-tech enterprises in Mainland China to foster industry-university-research collaborations, driving the Yangtze River Delta’s I&T development. A delegation led by Dr LAM Tai-fai, Council Chairman of PolyU; Prof. Jin-Guang TENG, President; Prof. Wing-tak WONG, Deputy President and Provost; and Prof. Christopher CHAO, Vice President (Research and Innovation) visited Wuxi and met with Mr DU Xiaogang, Communist Party Secretary of Wuxi; Mr ZHOU Changqing, Member of the Wuxi Party Committee Standing Committee and Head of the United Front Work Department; Mr QIN Yongxin and Mr ZHOU Wendong, Vice Mayors of Wuxi; and Mr CUI Rongguo, Party Chief of Wuxi National Hi-tech District and Party Secretary of Xinwu District. They had an in-depth exchange on reinforcing cooperation between Jiangsu and Hong Kong, along with leaders of various levels from the Wuxi Municipal Government and representatives from domestic companies. PolyU is the first Hong Kong tertiary institution to establish a research institute in Wuxi and participate in the Yangtze River Delta’s I&T drive. The Institute will focus on three key areas: building an internationally high-end research and innovation platform in the fields of aviation and aeronautical engineering, advanced manufacturing, biomedical engineering, artificial intelligence, new materials and telecommunications networks; establishing an incubation base to translate research outcomes into real-world solutions; and cultivating outstanding engineers and technopreneurs with a global perspective through PolyU’s leading engineering doctorate and postdoctoral fellowship programmes. The Institute will leverage PolyU’s global networks and impact to attract technology companies to the Wuxi High-Tech Industrial Development Zone, organise industry and academic exchange activities, and expand channels for international exchange and collaborations. To facilitate the translation of research achievements, the Institute signed agreements with ten domestic high-tech enterprises in Wuxi, namely Wuxi Hyatech Co., Ltd; Jiangsu Asia-pacific Aviation Technology Co., Ltd; Xiangsheng Biomedical Technology Co., Ltd; Jiangsu Sanlian Bioengineering Co., Ltd; Wuxi International Life Science Innovation Campus; Wuxi Autowell Technology Co., Ltd; Hymson Laser Technology Group Co., Ltd; Tonghe Carbon Materials Technology (Wuxi) Co., Ltd; Loulan Technology (Jiangsu) Co., Ltd; and GRG Metrology & Test (Wuxi) Co., Ltd. The Institute will serve as a platform to facilitate knowledge transfer and support enterprises in achieving technological advancement by leveraging PolyU’s expertise in innovation and research. Dr Lam Tai-fai, remarked, “By capitalising on its expertise in talent development, academic and research innovations, and global network, PolyU will collaborate with Wuxi’s industries to enhance R&D services, expedite the translation of research outcomes into practical applications, and promote industrial upgrading. By pooling our efforts, we can unlock the powerful synergy between government, industry and academia enabling us to open a new chapter for the I&T development of Jiangsu, Hong Kong and the Nation.” During the visit, the PolyU delegates also introduced to the Wuxi Municipal Government and enterprise representatives the University’s engineering doctorate programmes, research achievements in biomedical engineering through industry-academic-research collaborations, as well as the Institute’s future development and talent development plans. Moving forward, the Institute will continue to join hands with Wuxi’s higher education institutions and enterprises in building an innovation ecosystem that will contribute to the high-quality development of Wuxi, Hong Kong and the Nation.   ***END***

3 Nov, 2023

Research and Innovation Office

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Young PolyU scientist lauded in MIT Technology Review Innovators Under 35 Asia Pacific 2023

The Hong Kong Polytechnic University (PolyU) Assistant Professor Dr Kathy K. LENG from the Department of Applied Physics, has been named by the Massachusetts Institute of Technology Review as one of the “Innovators Under 35” (TR35) in the Asia Pacific region in 2023. This prestigious recognition highlights Dr Leng’s outstanding achievements and advancements in science and technology innovation. Dr Leng is actively engaged in research focused on discovering new physics in the emerging field of molecularly thin 2D hybrid perovskites. She has developed a set of nanotechnology tools and methods for investigating these materials at the molecular level and harnessing their potential for multifunctional smart device applications. Currently, her team is focusing on the large-scale growth of molecularly thin 2D hybrid perovskite films and exploring their novel spintronic device applications. She is the first scholar to observe the atomic structure of molecularly thin hybrid perovskites and correlate it to their optoelectronic properties. She discovered that very thin perovskites undergo structural relaxation, resulting in changes to their optical properties, which can be reversibly controlled by light or strain. This breakthrough has enabled her to fabricate the first monolayer perovskite photodetector that converts light to electricity with very high efficiency. The capability to tune the optoelectronic properties of these materials through external stimuli enables applications in intelligent and multifunctional devices. This research outcome will play a significant role in advancing the field of flexible optoelectronics and fundamental physics in the future. Dr Leng said, “Throughout my research journey, I have been inspired and encouraged by my peers and senior colleagues. Some of them have served as my mentor and role model, while others have collaborated with me and provided advice. Being part of this supportive and collaborative research network gives me much inspiration and encouragement. Recognition through impactful publications, grants, and conference presentations also spurs me on to work harder.” Based on her niche area of molecularly thin 2D hybrid perovskites, Dr Leng has recently received several awards in recognition for her outstanding achievements, including the Excellent Young Scientist Fund (Hong Kong and Macau) from the National Natural Science Foundation of China in 2023. She was also the recipient of a Young Innovative Researcher Award 2023 from PolyU. Prof. Christopher CHAO, Vice President (Research and Innovation) of PolyU, said, “PolyU has consistently dedicated itself to nurturing exceptional young scientists, providing ample resources to cultivate a vibrant environment for innovation and technology, and advocating for groundbreaking research. We take great pride in honouring PolyU’s talented scholars as they shine globally through their remarkable scientific research capabilities and impactful contributions.” MIT Technology Review identifies the TR35 annually from diverse technical fields, including biotechnology and medicine, energy and material, artificial intelligence, quantum computing and telecommunications, and intelligent manufacturing. This recognition is given to 35 top-notch young innovators who have demonstrated significant impact, leading capabilities, and ground-breaking achievements in their respective research areas.   ***END***

3 Nov, 2023

Department of Applied Physics

1b

PolyU develops first-of-its-kind multimodal robot empowering post-stroke ankle-foot telerehabilitation

The Hong Kong Polytechnic University (PolyU) has achieved another breakthrough in rehabilitation device development. The Mobile Ankle-foot Exoneuromusculoskeleton is the first-of-its-kind multimodal robot for ankle-foot rehabilitation specifically designed for stroke patients with hemiplegia, which helps improve the motor function of their lower limb and walking ability. Powered by Internet of Things (IoT) technology, the device enables telerehabilitation for remote management of patients’ rehabilitation progress and allows them to undertake self-help rehabilitation exercises at home. Therapists can remotely monitor the rehabilitation progress of multiple patients. In recent years, Hong Kong has seen around 50,000 new cases of stroke annually, with 85% of patients experiencing varying degrees of impaired physical mobility. Regular, repeated and intensive rehabilitation training is critical for restoring the physical mobility of stroke patients, thereby alleviating post-stroke symptoms such as disability. However, due to overwhelming demand, access to daytime outpatient rehabilitation services in local hospitals and rehabilitation clinics is challenging. Consequently, stroke patients are often unable to undergo timely and routine rehabilitation exercises. Common functional impairments among stroke patients include foot drop and inversion, which significantly disrupt their daily lives. Developed by a research team led by Dr Hu Xiaoling, Associate Professor of the Department of Biomedical Engineering of PolyU, the Mobile Ankle-foot Exoneuromusculoskeleton is an innovative multimodal wearable robot for ankle-foot rehabilitation that integrates the advantages of exoskeleton, soft pneumatic muscles, tactile sensory feedback and neuromuscular electrical stimulation technology in one system. The device can not only correct foot drop and foot inversion effectively, but also improve the gait of stroke patients. Additionally, it can help improve balance while walking and contribute to rehabilitative neuroplasticity in the long term. Stroke patients with hemiplegia generally have weakened muscle strength and discoordination at their affected lower limb, especially in the foot and ankle. The Mobile Ankle-foot Exoneuromusculoskeleton can automatically detect patients’ gait events including the standing state, heel strike, heel off and toe off. The multimodal assistance from the device can help a patient stand firm on their affected foot with mechanical support from the exoskeleton and soft pneumatic muscles, learn to balance the plantar pressure and exert propelling force when walking with the vibration tactile feedback and neuromuscular electrical stimulation, and improve foot drop with the neuromuscular electrical stimulation. The Mobile Ankle-foot Exoneuromusculoskeleton features a lightweight design weighing about 400g which, together with its sportswear features, makes it more suitable for the hemiplegic patients to wear it unilaterally on their own. This device also has the advantage of low power consumption and can be used continuously for four hours with a 9V rechargeable battery, enabling patients to practice anytime, anywhere – at home, outdoors, or indoors. Other exoskeleton lower-limb robots available on the market, which rely solely on external force to assist patients in walking, they are of very limited value in improving ankle joint and muscle coordination for stroke patients with hemiplegia. These robots are also limited to use in hospitals and rehabilitation clinics due to their high weight and power consumption. As for conventional ankle-foot orthoses, these are prone to causing muscle atrophy and interference to patients regaining voluntary motor control over the ankle of the affected leg. Dr Hu stated, “Combining the research capabilities of the Department of Biomedical Engineering, Industrial Centre, School of Fashion and Textiles and Department of Computing, the Mobile Ankle-foot Exoneuromusculoskeleton is a testament to PolyU’s exceptional strength in interdisciplinary research. This research achievement provides stroke patients a better option for lower limb rehabilitation training, incorporating the training into their daily activities. It also enables therapists to provide tele-supervision of the rehabilitation progress of multiple patients. We hope such flexible self-help training can effectively supplement traditional outpatient rehabilitation services, helping stroke patients achieve more efficient rehabilitation progress.” Dr Hu’s research team is collaborating with several local and Mainland hospitals and rehabilitation clinics to conduct clinical studies on the Mobile Ankle-foot Exoneuromusculoskeleton. Research studies have confirmed that rehabilitation training for stroke patients using the device is 40% more effective for stroke rehabilitation than applying external mechanical forces alone. Among the 12 patients participating in the clinical studies who completed a 1.5-month training programme consisting of 20 one-and-a-half-hour sessions, ankle dorsiflexion improved from an initial five degrees to 10 degrees without equipment assistance, approaching the normal level of 15 degrees. In addition, more than 90% of the patients successfully corrected their foot inversion. The research team also utilised IoT technology to record patients’ rehabilitation progress via a mobile app. This approach, incorporating functions such as real-time monitoring and progressive evaluation, as well as personalised guidance and reminders, enables patients to effectively engage in rehabilitation training even without the physical presence of a therapist, thereby improving patient engagement and treatment outcomes. The rehabilitation progresses of multiple patients can be matched to each other via the app for fostering mutual support and companionship throughout their training journey. It also enables therapists to provide remote monitoring and supervision on the progress of multiple patients, ensuring that rehabilitation proceeds smoothly. Dr Hu’s research team plans to commercialise the Mobile Ankle-foot Exoneuromusculoskeleton next year. In 2021, she co-founded the startup Thecon Technology (HK) Limited, which has been supported by the Incu-Bio Programme of Hong Kong Science and Technology Parks. Last year, the startup successfully launched a mobile exoneuromusculoskeleton for upper limb rehabilitation, the “Mobilexo Arm”, onto the market. This product has been adopted by a number of local and Mainland hospitals and rehabilitation clinics.   ***END***

31 Oct, 2023

Department of Biomedical Engineering

1

Healthy Ageing Conference 2023 Advancing Healthy Ageing in the Western Pacific Moving Forward with the UN Decade of Healthy Ageing

Population ageing is a pressing priority in the Western Pacific region, home to one of the world's largest and fastest-growing elderly populations. Recognizing the significance of this issue, the World Health Organization (WHO) has taken the lead in developing an action plan on healthy ageing for the region, aligned with the United Nations (UN) Decade of Healthy Ageing (2021–2030). In line with these efforts, the Healthy Ageing Conference 2023 was successfully held in Hong Kong on 26-27 October 2023. The conference, organized by the World Health Organization Collaborating Centre for Community Health Services, School of Nursing of The Hong Kong Polytechnic University (PolyU), and co-organized by the Department of Health of The Government of Hong Kong Special Administrative Region (HKSAR), PolyU Research Institute of Smart Ageing, and PolyU Department of Rehabilitation Sciences, served as a crucial platform to address the challenges and explore innovative solutions for healthy ageing in the region. The conference's opening ceremony marked its official commencement, with esteemed speakers delivering their addresses. Prof. Jin-Guang TENG, President of PolyU, welcomed participants and emphasized the pivotal role of the conference in realizing the United Nations' vision of healthy ageing. “The conference aimed to address the multifaceted factors influencing the well-being of older individuals and their families. It provided a platform to showcase cutting-edge gerontechnological innovations, discuss the latest interventions and advancements in epidemiology, and identify comprehensive strategies for implementing the WHO's action items.” Prof. TENG remarked. Mr ZHANG Hui, Counsellor (DG level) from the Department of Ageing and Health, National Health Commission of the People's Republic of China, emphasized healthy ageing was the least costly and most effective means and ways to cope with population ageing. The Chinese government had been positively responding to the United Nations Decade of Healthy Ageing (2021-2030). Mr. ZHANG highlighted the significance of collaboration and knowledge exchange between Mainland China, Hong Kong, and Macao in various aspects such as scientific research, technologies, projects, standards, norms, talents, services, and industries related to healthy ageing and elderly care. Mr ZHANG Hui expressed, "The National Health Commission will continue to strengthen exchanges and cooperation with Hong Kong and Macao in the field of healthy aging, learn from each other and complement each other's advantages." Prof. Chung-mau LO, Secretary of Health, Health Bureau of the HKSAR Government, emphasized that the government acknowledges the significant challenges posed by the rapidly ageing population. The government is committed to implementing a comprehensive structural reform that will transition the healthcare system from a treatment-oriented approach to a prevention-focused approach, and shift the service delivery from hospital-based to community-based settings. Prof. LO stated, "Our ultimate goal is to enhance the overall health of the population, ensure accessible and integrated healthcare services, and establish a sustainable healthcare system." Dr Ronald LAM, Director of Health from the Department of Health of the HKSAR Government, reiterated the unwavering commitment of the HKSAR Government to promote healthy ageing. Dr LAM emphasized that a comprehensive policy on healthy ageing has been formulated based on the recommendations of the Elderly Commission. Various programmes aimed at promoting the well-being of older adults are being implemented by the Department of Health, including health education for all age groups, caregiver training, and supports the revitalization of primary healthcare services. “Meeting the challenges of Silver Tsunami would require not only cross-sectoral, but also international collaboration. Let’s join hands for the health and well-being of our senior citizens.” said Dr LAM. Dr Hiromasa OKAYASU, Director of the Division of Healthy Environments and Populations at the WHO Western Pacific Regional Office (WPRO), reaffirmed that the conference offered an exceptional platform for policymakers, stakeholders, practitioners, researchers, and academics to come together and address the pressing trends and challenges related to population ageing in the region. Dr OKAYASU stated, "The Hong Kong Polytechnic University's School of Nursing made significant efforts to facilitate a wide range of discussions, encompassing research and practical ideas, all with the aim of enhancing healthy ageing." Prof. Angela Yee-man LEUNG, Director of the World Health Organization Collaborating Centre for Community Health Services, School of Nursing at PolyU, shed light on the prevalent issue of intrinsic capacity decline among community-dwelling older adults in Hong Kong. “Efforts have been made to promote the adoption of the World Health Organization's integrated care for older people (ICOPE) Framework in Hong Kong. This includes the provision of a comprehensive training package and experience-sharing symposium, with the aim of facilitating the effective implementation of the ICOPE approach. Notably, we are pleased to witness the successful trial run of the ICOPE model by Wong Tai Sin District Health Centre.” said Prof. LEUNG. Furthermore, a series of webinars titled 'Embracing Ageing in the Western Pacific' has been regularly organized since 2020. These webinars create a valuable platform for experts in the region to exchange knowledge and ideas regarding emerging trends, best practices, and innovative solutions that promote healthy ageing. Prof. LEUNG added, "We are delighted to foster a collaborative environment that facilitates knowledge sharing and encourages advancements in the field of healthy ageing." The Healthy Ageing Conference 2023 represented a significant milestone in the pursuit of healthy ageing. By fostering collaboration, exchanging views and ideas, and sharing innovative approaches, the conference laid a solid foundation for implementing the Regional Action Plan on Healthy Ageing. Ultimately, the goal is to realize the visions outlined in the UN Decade of Healthy Ageing (2021–2030) and create a healthier, more inclusive future for older individuals and their communities. About World Health Organization Collaborating Centre for Community Health Services, School of Nursing, The Hong Kong Polytechnic University The World Health Organization (WHO) has designated PolyU’s School of Nursing as a WHO Collaborating Centre (WHO CC) for Community Health Services since December 2007. Through implementing the WHO’s mandate, the School has been playing a proactive role in strengthening evidence-based community health services and improving the health outcomes of local, regional and global populations. In 2019, The WHO re-designated the School’s WHO CC for Community Health Services with the focus that aligns with one of the WHO current strategic priorities - Healthy Ageing. The Centre is committed to the objectives of identifying crucial indicators of ageing and health within the region, actively advocating for and implementing the World Health Organization (WHO) Guidelines on Integrated Care for Older People (ICOPE), and establishing a platform for interdisciplinary collaborations between healthcare professionals and academia to initiate projects focused on promoting healthy ageing. About the Healthy Ageing Conference 2023 The Healthy Ageing Conference 2023 was an international event organised by the World Health Organization Collaborating Centre for Community Health Services, School of Nursing of The Hong Kong Polytechnic University (PolyU), and co-organised by the Department of Health of the Government of Hong Kong SAR, PolyU Research Institute of Smart Ageing, and PolyU Department of Rehabilitation Sciences. The conference aims to address the key trends and challenges associated with population ageing in the Western Pacific region, promote healthy ageing, and facilitate the implementation of actions in response to the UN Decade of Healthy Ageing. The Healthy Ageing Conference 2023 featured a comprehensive program encompassing a wide range of topics including healthcare innovations, social engagement, policy development, and technological advancements. Participants engaged in thought-provoking discussions, interactive workshops, and networking opportunities, fostering collaborations and inspiring initiatives to address the multifaceted aspects of healthy ageing. For more information about WHO's work on the UN Decade of Healthy Ageing (2021–2030), please visit the official website: https://www.who.int/initiatives/decade-of-healthy-ageing   ***END***

30 Oct, 2023

School of Nursing

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