- Y817-03
- +852 3400 8668
- xiaoli.dong@polyu.edu.hk
ORCID ID
SCOPUS IDEducation and Academic Qualifications
- Bachelor of Medicine, Jining Medical College
- Master of Medicine, Qingdao University Medical College
- Doctor of Philosophy, The Hong Kong Polytechnic University
Research Overview
My research interests include Pathogenic mechanism studies of age-related diseases including Parkinson's disease and osteoporosis, Novel therapy (Food-based therapies) development for treatment of neurodegenerative disease and bone disease and Functional food development for mental and bone health
Research Interests
Achievements
- 黄家兴，董晓莉，陆家谦，张兆滔。一种纳米硒水溶胶及其制备方法与应用。专利申请号：201911215358.5
- 黄文秀，董晓莉，曹思思，王奕。齐敦果酸和熊果酸在制备调节维生素D3代谢酶活性的药物中的应用。中国专利，已授权 专利号：ZL 2017 1 1061004.0
- 黄文秀，姚新生，邱佐成，董晓莉，戴毅。异戊烯基二氢黄酮类化合物在防治骨疾病领域的应用 中国专利，已授权 专利号：ZL 2016 1 0102211.5
- 李小花，董晓莉，赵清，张焕。三萜类化合物在制备治疗帕金森药物中的应用。中国专利，已授权 专利号：ZL 2015 1 0673284.5
- Liu X, Du ZR, Wang X, Luk KH, Chan CH, Cao X, Zhao Q, Zhao F, Wong WT, Wong KH*, Dong XL*. Colonic dopaminergic neurons changed reversely with those in the midbrain via gut microbiota-mediated autophagy in a chronic Parkinson's disease mice model. Frontiers in Aging Neuroscience, 2021, 13: 649627
- Dong XL, Wang X, Liu F, Liu X, Du ZR, Li RW, Hu XC, Wong KH, Wong WT, Zhao Q, Tang QJ*. Polymannuronic acid prevents dopaminergic neuronal loss via brain-gut-microbiota axis in Parkinson's disease model. International Journal of Biological Macromolecules, 2020, 164: 994-1005
- Dong XL, Yu WX, Li CM, He S, Zhou LP, Poon CW, Wong MS*. Danshen (Salvia miltiorrhiza) protects ovariectomized rats fed with high-saturated fat-sucrose diet from bone loss. Osteoporosis International, 2018, 29(1):223-235
- Cao S, Dong XL, Ho MX, Yu WX, Wong KC, Yao XS, Wong MS*. Oleanolic acid exerts osteoprotective effects and modulates vitamin D metabolism. Nutrients, 2018, 10 (2): 247
- Dong XL, Zhang JX, Zhou ZL, Ye ZN, Chen JH, Yuan JF, Cao FJ, Wang XB, Liu WC, Yu WX, Li XH*. Maslinic acid promotes autophagy by disrupting the interaction between Bcl2 and Beclin1 in rat phenochromocytoma PC12 cells. Oncotarget, 2017, 8(43):74527-74538
- Yu WX, Lin CQ, Zhao Q, Lin XJ*, Dong XL*. Neuroprotection against hydrogen peroxide-induced toxicity by Dictyophora echinovolvata polysaccharide via inhibiting the mitochondria-dependent apoptotic pathway. Biomedicine & Pharmacotherapy, 2017, 88, 569-573
- Zhao Q, Ye JL, Wei N, Fong CC, Dong XL*. Protection against MPP+-induced neurotoxicity in SH-SY5Y cells by tormentic acid via the activation of PI3-K/Akt/GSK3β pathway. Neurochemistry International, 2016, 97: 117-123
- Dong XL, Li CM, Cao SS, Zhou LP, Wong MS*. A high saturated fat, high sucrose diet aggravates bone loss in ovariectomized female rats. Journal of Nutrition, 2016, 146(6): 1172-1179
- Qiu ZC, Dong XL, Dai Y, Xiao GK, Wang XL, Wong KC, Wong MS*, Yao XS*. Discovery of a new class of cathepsin K inhibitors in Rhizoma Drynariae as potential candidates for the treatment of osteoporosis. International Journal of Molecular Sciences, 2016, 17, 2116
- Dong XL, Zhang Y, Wong MS*. Estrogen deficiency-induced Ca balance impairment is associated with decrease in expression of epithelial Ca transport proteins in aged female rats. Life Sciences, 2014, 96(1-2): 26-32
