ORCID IDResearch Overview
I aspire to advance the molecular understanding of pathogens and human diseases via the application of structural biology. My current projects include: polyglutamine expansion disease proteins, bacterial and viral virulent factors, proteins implicated in cell cycle control and cytoskeletal components.
Education and Academic Qualifications
- Bachelor of Science in Chemistry and Biochemistry, Imperial College London
- Doctor of Philosophy, University of Cambridge
- 2023- Associate Editor, Frontiers in Molecular Biosciences
Research Interests
Achievements
- Chen YW, Kong WP, Wong KY. The structural integrity of the membrane-embedded bacterial division complex FtsQBL studied with molecular dynamics simulations. Comput. Struct. Biotechnol. J. 2023; 21:2602-12.
- Kong WP, Chen YW, Wong KY. The crystal structure of the H116Q mutant of NDM-1: An enzyme devoid of zinc ions. J. Struct. Biol. 2022; 214(4):107922.
- Fung YH, Kong WP, Leung ASL, Du R, So PK, Wong WL, Leung YC, Chen YW, Wong KY. NDM-1 Zn1-binding residue His116 plays critical roles in antibiotic hydrolysis. Biochim. Biophys. Acta – Proteins & Proteomics 2022; 1870:140833.
- Kong WP, Gong F, So PK, Chen YW, Chan PH, Leung YC, Wong KY. The structural dynamics of full-length divisome transmembrane proteins FtsQ, FtsB, and FtsL in FtsQBL complex formation. J. Biol. Chem. 2022; 298:102235.
- Lo HS, Hui KP … Ng WL. Simeprevir potently suppresses SARS-CoV-2 replication and synergizes with remdesivir. ACS Cent. Sci. 2021;7:792
- Tang YS, Xu S, Chen YW, Wang JH, Shaw PC. Crystal structures of influenza nucleoprotein complexed with nucleic acid provide insights into the mechanism of RNA interaction. Nucleic Acids Res. 2021; 49:4144.
- Chen YW, Rahman SK. Fatal attraction: the case of toxic soluble dimers of truncated PQBP-1 mutants in X-linked intellectual disability. Int. J. Mol. Sci. 2021;22:2240.
- Huang L, So PK, Chen YW, Leung YC, Yao ZP. Conformational dynamics of the helix 10 region as an allosteric site in class A β‑lactamase inhibitory binding. J. Amer. Chem. Soc. 2020;142:13756–67.
- Chen YW, Yiu CPB, Wong KY. Prediction of the SARS-CoV-2 (2019-nCoV) 3C-like protease (3CLpro) structure: virtual screening reveals velpatasvir, ledipasvir, and other drug repurposing candidates. F1000 Res. 2020;9:129.
- Rahman SK, Okazawa H, Chen YW. Frameshift PQBP-1 mutants K192Sfs*7 and R153Sfs*41 implicated in X-linked intellectual disability form stable dimers. J. Struct. Biol. 2019;206:305–11.
- Chen, Yu Wai, Wang, Yong, Leung, Yun-Chung, Wong, Kwok-Yin. "Parameterization of Large Ligands for Gromacs Molecular Dynamics Simulation with LigParGen." Structural Genomics - General Applications, Second Edition, edited by Yu Wai Chen and Chin-Pang Bennu Yiu, Humana Press, 2021, pp. 277-288.
- Yiu, Chin-Pang Bennu, Chen, Yu Wai. "Molecular Data Visualization on Mobile Devices: A Quick Starter's Guide." Structural Genomics - General Applications, Second Edition, edited by Yu Wai Chen and Chin-Pang Bennu Yiu, Humana Press, 2021, pp. 337-346.
- Yiu, Chin-Pang Bennu, Chen, Yu Wai. "Molecular Data Visualization with Augmented Reality (AR) on Mobile Devices." Structural Genomics - General Applications, Second Edition, edited by Yu Wai Chen and Chin-Pang Bennu Yiu, Humana Press, 2021, pp. 347-356.
