Dr Keng Wee-keong, Vincent

PolyU Scholars Hub

DoCAF & Assoc. Professor

Y803
+852 3400 8728
vincent.keng@polyu.edu.hk

PolyU Scholars Hub

ORCID ID

SCOPUS ID

Education and Academic Qualifications

Doctor of Philosophy, Fukui Medical University

Research Overview

Our research group focuses on elucidating the genetic mechanisms of various types of human cancers. The information obtained will translate to better disease prevention, diagnosis and establishing effective therapeutic regimes.

Research Interests

Achievements

To, J.C., Chiu, A.P., Tschida, B.R., Lo, L.H., Chiu, C.H., Li, X.X., Kuka, T.P., Linden, M.A., Amin, K., Chan, W.C., Bell, J.B., Moriarity, B.S., Largaespada, D.A.** & Keng, V.W.** (2021) ZBTB20 regulates WNT/CTNNB1 signaling pathway by suppressing PPARG during hepatocellular carcinoma tumourigenesis. JHEP Reports. 3, 100223. [https://doi.org/10.1016/j.jhepr.2020.100223].
Li, X.X., Zhang, S.J., Man, K.Y., Chiu, A.P., Lo, L.H., To, J.C., Chiu, C.H., Chan, C.O., Mok, D.K.W., Rowlands, D.K. & Keng, V.W.* (2020) Schwann cell-specific Pten inactivation reveals essential role of the sympathetic nervous system activity in adipose tissue development. Biochem. Biophys. Res. Comm. 531, 118-124.
Conboy, C.B., Vélez-Reyes, G.L., Tschida, B.R., Hu, H., Kaufmann, G., Koes, N., Keller, B., Alsinet, C., Cornellà, H., Pinyol, R., Abrahante, J.E., Temiz, N.A., Linden, M.A., Amin, K., Kuka, T.P., Keng, V.W., Llovet, J.M., Starr, T.K. & Largaespada, D.A. (2019) RSPO2 drives liver tumor development in a YAP-dependent manner. Hepatology Comm. 3, 1496-1509.
Zhang, S.J., Li, X.X., Yu, Y., Chiu, A.P., Lo, L.H., To, J.C., Rowlands, D.K. & Keng, V.W.* (2019) Schwann cell-specific PTEN and EGFR dysfunctions affect neuromuscular junction development by impairing Argrin signaling and autophagy. Biochem. Biophys. Res. Comm. 515, 50-56.
Chiu, A.P., Tschida, B.R., Sham, T.T., Lo, L.H., Moriarity, B.S., Li, X.X., Lo, R.C., Hinton, D.E., Rowlands, D.K., Chan, C.O., Mok, D.K.W., Largaespada, D.A., Warner, N. & Keng, V.W.* (2019) HBx-K130M/V131I promotes liver cancer in transgenic mice via AKT/FOXO1 signaling pathway and arachidonic acid metabolism. Mol. Cancer Res. 17, 1582-1593.
Li, X.X., Lu, X.Y., Zhang, S.J., Chiu, A.P., Lo, L.H., Largaespada, D.A., Chen, Q.B.** & Keng, V.W.** (2019) Sodium tanshinone IIA sulfonate ameliorates hepatic steatosis by inhibiting lipogenesis and inflammation. Biomed. Pharmacother. 111, 68-75.
Chiu, A.P. & Keng, V.W.* (2019) Liver-specific delivery of Sleeping Beauty transposon system by hydrodynamic injection for cancer gene validation. Methods Mol. Biol. 1907, 185-196.
Li, X.X., Zhang, S.J., Chiu, A.P., Lo, L.H., To, J.C., Cui, H.N. & Keng, V.W.* (2019) Conditional inactivation of Nf1 and Pten in Schwann cells results in abnormal neuromuscular junction maturation. G3 (Bethesda) 9, 297-303.
Li, X.X., Zhang, S.J., Chiu, A.P., Lo, L.H., Huang, J., Rowlands, D.K., Wang, J. & Keng, V.W.* (2018) Targeting of AKT/ERK/CTNNB1 by DAW22 as a potential therapeutic compound for malignant peripheral nerve sheath tumor. Cancer Med. 7, 4791-4800.
Riordan, J.D., Feddersen, C.R., Tschida, B.R., Beckmann, P.J., Keng, V.W., Linden, M.A., Amin, K., Stipp, C.S., Largaespada, D.A. & Dupuy, A.J. (2018) Chronic liver injury alters driver mutation profiles in hepatocellular carcinoma in mice. Hepatology. 67, 924-939.
Tschida, B.R., Temiz, A., Kuka, T.P. Lee, L.A., Riordan, J.D., Tierrablanca, C.A., Hullsiek, R., Wagner, S., Hudson, W.A., Linden, M.A., Amin, K., Beckmann, P.J., Heuer, R.A., Sarver, A.L. Yang, J.D., Roberts, L.R., Nadeau, J.H., Dupuy, A.J., Keng, V.W.**, & Largaespada, D.A.** (2017) Sleeping Beauty insertional mutagenesis in mice identifies steatosis-associated hepatic tumor drivers. Cancer Res. 77, 6576-6588.
Wu, J., Keng, V.W., Patmore, D.M., Kendall, J.J., Patel, A.V., Jousma, E., Jessen, W.J., Choi, K., Tschida, B.R., Silverstein, K.A.T., Fan, D., Schwartz, E.B., Fuchs, J.R., Zou, Y., Kim, M., Dombi, E., Levy, D.E., Huang, G., Cancelas, J.A., Stemmer-Rachanimov, A.O., Spinner, R.J., Largaespada, D.A. & Ratner, N. (2016) Insertional mutagenesis identifies a STAT3/Arid1a/ß-catenin pathway driving neurofibroma initiation. Cell Rep. 14, 1979-1990.