The demand for logistics services keeps rising owing to a high volume of throughput across the border. The rise of e-commerce results in the purchase of a wide variety of products in low quantities. This new trend of consumer behavior increased the complexity of logistics operation. To cope with the challenges created by the changing consumption patterns, PolyU collaborates with an industrial partner to develop a Cloud-based Cyber-Physical Logistics System with big data analytics technology and swarm intelligence. It provides real time data acquisition, automatic assignment of pick-up-and-delivery orders, optimal vehicle scheduling and visualization of delivery status. With the proposed system and e-commerce platform, logistics service providers can enhance their accuracy and efficiency in logistics operations and optimize human resources, while consumers can have better experience in the pickup and delivery of the products.