RCSV & SO Joint Research Forum - "Data-driven understanding of personalized medicine"
Research Institute / Research Centre Seminar
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Date
19 Jul 2024
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Organiser
School of Optometry (SO); Research Centre for SHARP Vision (RCSV)
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Time
15:00 - 16:00
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Venue
AG204
Speaker
Dr Zhou Xin
Enquiry
Ms Shirley NG (852) 3400 2312 info.rcsv@polyu.edu.hk
Summary
Human diseases often have complex etiologies, necessitating the study of precision medicine for effective therapeutics. Cohort studies are crucial for understanding phenotype variation and disease mechanisms. We present examples of human cohort studies on human-bacteria interactions, examining immune, metabolic, and mental health phenotypes in both healthy and diseased states. These studies integrate metagenomic, transcriptomic, and metabolomic data to reveal the microbiome's impact on health. Additionally, we introduce an innovative organoid system for mechanistic validation of cohort study findings, offering an advanced alternative to animal models. This approach demonstrates how big data and bioinformatics are driving precision medicine, enhancing diagnosis and intervention strategies. Our work aims to improve personalized medicine by leveraging multiomics data and advanced experimental models for more tailored treatments.
Keynote Speaker
Dr Zhou Xin
Postdoctoral Fellow, Michael Snyder Lab, Stanford University
Xin Zhou is a Research Scientist at the Stanford University School of Medicine. He earned his Ph.D. under the mentorship of George Weinstock and completed his postdoctoral training with Michael Snyder. Xin's research focuses on host-microbial interactions in health and disease. He has published 28 research papers, including Cell Host & Microbe (Cover Story) and Circulation Research. His work has been cited over 1100 times. Xin has received several grants including the NIA Resource Centers for Minority Aging Research Fellowship, the Bill & Melinda Gates Foundation grant through Stanford Innovative Medicines Accelerator etc. Xin serves as reviewers for several journals such as National Science Review and Molecular Psychiatry.