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Professor Mo YANG

Professor Mo YANG

Director of RCBPT

Department of Biomedical Engineering

Biography

Prof. YANG Mo received the B.E. and M.S. degrees in Power Mechanical Engineering from Shanghai Jiaotong University, China, in 1998 and 2001, respectively. He received the Ph.D. degree in Mechanical Engineering from the University of California, Riverside, in 2004. From Jan 2005 to Oct 2005, he was a Postdoctoral Research Associate in Mechanical Engineering of Boston University. He is currently a Professor at Department of Biomedical Engineering, Faculty of Engineering in the Hong Kong Polytechnic University and the director for Joint Research Center of Biosensing and Precision Theranostics. Prof. Yang’s research focuses on microfluidic device for biosensing and nanomaterials based bioprobes for bioimaging, biosensing and precision theranostics. Prof. Yang has published more than 130 journal papers and is involved in 4 US patents and 4 China patents. He has been in charge of many research projects including 3 Hong Kong Research Grant Council Collaborative Research Fund (CRF) as Principle Coordinator (2024, 2022, 2020), 9 Hong Kong Research Grant Council General Research Fund (GRF) as Principle Investigators, 2 National Natural Science Foundation of China (NSFC) fund and 2 Innovation and Technology Fund (ITF) as Principle Investigators, 1 深港澳科技計劃項目(c) as Principle Investigator, and 1 Research Grant Council Collaborative Research Fund (CRF) as Co-PI etc.

Yang's Lab Website: https://979773507.wixsite.com/yang-s-lab

Research Interests

  • Bio-nanotechnology
  • Biosensing
  • Theranostics
  • Lab-on-a-chip

Professional Qualifications

  • Life Member of the World Association for Chinese Biomedical Engineers

Academic and Professional Experiences

  • Director, Joint Research Center of Biosensing and Precision Theranostics, the Hong Kong Polytechnic University, Nov 2023 - current 
  • Associate Director, University Research Facility in Life Sciences, the Hong Kong Polytechnic University, April 2023 - current
  • Associate head (Research), Department of Biomedical Engineering, Faculty of Engineering, the Hong Kong Polytechnic University, Jul 2018 - current
  • Professor, Department of Biomedical Engineering, Faculty of Engineering, the Hong Kong Polytechnic University, Jul 2018 - current
  • Associate Professor, Department of Biomedical Engineering, Faculty of Engineering, the Hong Kong Polytechnic University, Oct 2017 - Jun 2018
  • Associate Professor, Interdisciplinary Division of Biomedical Engineering, Faculty of Engineering, the Hong Kong Polytechnic University, Jul 2012 - Oct 2017
  • Assistant Professor, Interdisciplinary Division of Biomedical Engineering, Faculty of Engineering, the Hong Kong Polytechnic University, Apr 2012 - Jul 2012
  • Assistant Professor, Biomedical Engineering Programme, Department of Health Technology and Informatics, the Hong Kong Polytechnic University, Oct 2005 - Apr 2012
  • Postdoctoral Research Associate, Boston University, MA, United States, Jan 2005 - Oct 2005

Research Output

  • H-index: 42 (ISI Web of Knowledge, Research ID: K-1274-2012) / 42 (Scopus, ID: 7404927250) /47 (Google Scholar) ORCID: (0000-0002-3863-8187) 
  • The paper "Ultrasensitive detection of ebola virus oligonucleotide based on upconversion nanoprobe/nanoporous membrane" (ACS Nano 10(1) 598-605, 2016) is “Highly Cited Paper” in Essential Science Indicators (ESI) ( top 1% of the academic field of Chemistry) 
  • The paper "J.Y. Shi, C.Y. Chan, Y.T. Pang, W.W. Ye, F. Tian, J. Lyu, Y. Zhang, M. Yang, "A fluorescence resonance energy transfer (FRET) biosensor based on graphene quantum dots (GQDs) and gold nanoparticles (AuNPs) for the detection of mecA gene sequence of Staphylococcus aureus", Biosensors and Bioelectronics 67, 595–600, 2015." is “Highly Cited Paper” in Essential Science Indicators (ESI) ( top 1% of the academic field of Chemistry) 
  • The paper "F. Tian, J. Lyu, J.Y Shi, M. Yang* Graphene and graphene-like two-denominational materials based fluorescence resonance energy transfer (FRET) assays for biological applications, Biosensors and Bioelectronics, 89(1), 123-135, 2017." is "Highly Cited Paper" in Essential Science Indicators (ESI) ( top 1% of the academic field of Chemistry) 
  • The paper "Nanoparticle based fluorescence resonance energy transfer (FRET) for biosensing applications", (J. Mater. Chem. B, 3, 6989-7005, 2015) is among the most downloaded article of Journal of Material Chemistry B in 2015
  • X.Y. Lao, Y.L. Liu, L.H. Li, M.L. Song, Y.J. Ma, M. Yang, G.Y. Chen, J.H. Hao Plasmon-enhanced FRET biosensor based on Tm3+/Er3+ co-doped core-shell upconversion nanoparticles for ultrasensitive virus detection, Aggregate (In press).
  • J.R. Chen, W.K.H.H. Ho, B.H. Yin, Q. Zhang, C.Q. Li, J.X. Yan, Y.Y. Huang, J.H. Hao, C.Q. Yi, Y. Zhang, S.H.D. Wong,* M. Yang* Magnetic-responsive upconversion luminescence resonance energy transfer (LRET) biosensor for ultrasensitive detection of SARS-CoV-2 spike protein, Biosensors & Bioelectronics, 2024, 248, 115969.
  • Y.L. Ma, M.L. Song, L.H. Li, X.Y. Lao, Y. Liu, M.C. Wong, M. Yang, H.L. Chen, J.H. Hao, Attomolar-level detection of respiratory virus long-chain oligonucleotides based on FRET biosensor with upconversion nanoparticles and Au–Au dimer, Biosensors & Bioelectronics, 2024, 243, 115778.

     

  • Z.W. Li, Z.Q. Meng, F. Tian, X.F. Zhou, X.J. Zhong, Q. Chen, M. Yang, Z. Liu, Y. D. Yin, FFT-weighted photoacoustic imaging by in vivo magnetic alignment of hybrid nanorods, Nano Letters 2023, 23, 19, 9160–9169.
  • Z.J. Huang, G.C.P. Tsui, K.W. Yeung, C. Li, C.Y. Tang, M. Yang, M. Zhang, W.Y. Wong 4D direct laser writing of photo-triggered liquid crystal elastomer microactuators with large actuation strain, Materials & Design, 2023, 232, 112101.
  • T.P. Xu, Y.H. Yang, E.H.L. Yeung, Q.C. Chen, H.P. Bei, Q. Yang, M. Yang, Y.F. Hao, B. Li, X. Zhao, Injectable, self-contained, subaqueously cross-linking laminous adhesives for biophysical-chemical modulation of osteochondral microenvironment, Advanced Functional Materials, 2023, 33(23), 2213428.
  • M. Xiao, F. Tian, X. Liu, Q.Q. Zhou, J.F. Pan, Z.F. Luo*, M. Yang*, C.Q. Yi*, Virus detection: From state-of-the-art laboratories to smartphone-based point-of-care testing, Advanced Science, 2022, 2105904.
  • Q. Zhang, B.H. Yin, Y.Y. Huang, Y.T. Gu, J.X. Yan, J.R. Chen, C.Q. Li, Y. Zhang, S.H.D. Wong*, M. Yang*, A dual “turn-on” biosensor based on AIE effect and FRET for in situ detection of miR-125b biomarker in early Alzheimer's disease, Biosensors & Bioelectronics, 2023, 230, 115270.
  • B.H. Yin, W.K.H. Ho, X.Y. Xia, C.K.W. Chan, Q. Zhang, Y. M. Ng, J.C.W. Cheung, J.F. Wang, M. Yang*, S.H.D. Wong*, A multilayered mesoporous gold nanoarchitecture for ultraeffective near-infrared light-controlled chemo/photothermal therapy for cancer guided by SERS imaging, Small 202319(6) 2206762
  • Q. Zhang, B.H. Yin, J.H. Hao, L.J. Ma, Y.Y. Huang, X.Y. Shao, C.Q. Li, Z.Q. Chu, C.Q. Yi, S.H.D. Wong*, M. Yang*, An AIEgen/graphene oxide nanocomposite (AIEgen@GO)-basedtwo-stage “turn-on” nucleic acid biosensor for rapid detectionof SARS-CoV-2 viral sequence, Aggregate, 20234 (1) e195.
  • M.L. Song, M.C. Wong, L.H. Li, F. Guo, Y. Liu, Y.J. Ma, X.Y. Lao, P. Wang, H.L. Chen, M. Yang, J.H. Hao, Rapid point-of-care detection of SARS-CoV-2 RNA with smartphone-based upconversion luminescence diagnostics, Biosensors & Bioelectronics, 2023, 222, 114987.
  • L.H. Li, ML, Song, XY Lao, S.Y. Pang, Y.L. Liu, M.C. Wong, Y.J. Ma, M. Yang, J.H. Hao, Rapid and ultrasensitive detection of SARS-CoV-2 spike protein based on upconversion luminescence biosensor for COVID-19 point-of-care diagnostics, Materials & Design, 2022, 223, 111263.
  • J.Y. Chen#, G. Oudeng#, H.T. Feng, S.X. Liu, H.W. Li, Y.P. Ho, Y. Chen*, Y. Tan*, M. Yang*, 2D MOF nanosensor-integrated digital droplet microfluidic flow cytometry for in-situ detection of multiple miRNAs in single CTC cells, Small, 2022, 18(32), 2201779.
  • F.Y. Qu, L.Y. Zhao, L.Q. Li, S.R. Zhao, M. Yang, J. Yu, Y.P. Ho, Thermo-induced coalescence of dual cores in double emulsions for single cell RT-PCR, Analytical Chemistry, 2022, 94, 33, 11670–11678.
  • B.H. Yin, W.K.H. Ho, Q. Zhang, C.Q. Li, Y.Y. Huang, J.X., Yan, H.R. Yang, J.H. Hao, S.H.D. Wong*, M. Yang*, Magnetic-responsive surface-enhanced raman scattering platform with tunable hot spot for ultrasensitive virus nucleic acid detection, ACS Applied Materials & Interfaces, 2022, 14, 3, 4714–4724.
  • D. Jiang, Y.D. Zhang, X.J. Du, Y.H. Tan, W. Chen, M. Yang*, Wavelength-regulated switchable photoelectrochemical system for concurrent detection of dual antibiotics, Biosensors & Bioelectronics, 2022, 202, 113999.
  • B.H. Yin, J.G. Ni, C.E. Witherel, M. Yang, J.A. Burdick, C.Y. Wen, S.H.D., Harnessing tissue-derived extracellular vesicles for osteoarthritis theranostics, Theranostics, 2022, 12(1), 207–231.
  • Z.W. Li, Z.Q. Meng, F. Tian, X.F. Zhou, X.J. Zhong, Q. Chen, M. Yang, Z. Liu, Y. D. Yin*, FFT-weighted photoacoustic imaging by in vivo magnetic alignment of hybrid nanorods, Nano Letters, 2022, 22, 13, 5158–5166.
  • F. Tian, S.Y. Wang, K.D. Shi, X.J. Zhong, Y.T. Gu, Y.D. Fan, Y. Zhang, M. Yang*, Dual-depletion of intratumoral lactate and ATP with radicals generation for cascade metabolic-chemodynamic therapy, Advanced Science, 2021, 8(24), 2012595.
  • L. Zhang#, Y.D. Fan#, Z. Yang, M. Yang*, C.Y. Wong*, NIR-II-driven and glutathione depletion-enhanced hypoxia-irrelevant free radicals nanogenerator for combined cancer therapy, Journal of Nanobiotechnology, 2021 19, 265 (# equivalent contribution)
  • M.T. Au#, J.Y. Shi#, Y.D. Fan, J.G. Ni, C.Y. Wen*, M. Yang*, Nerve growth factor-targeted molecular theranostics based on molybdenum disulfide nanosheet coated gold nanorods (MoS2-AuNR) for osteoarthritis pain, ACS Nano (In Press, # Co-first authors)
  • D. Jiang, C.Q. Yang, Y.D. Fan, P. H.M. Leung, I. Kiao, Y. Zhang, Z.Y. Li, M. Yang*, Ultra-sensitive photoelectrochemical aptamer biosensor for detecting E. coli O157:H7 based on nonmetallic plasmonic two-dimensional hydrated defective tungsten oxide nanosheets coupling with nitrogen-doped graphene quantum dots (dWO3·H2O@N-GQDs), Biosensors and Bioelectronics, 183, 113214, 2021
  • G. Oudeng, M. Benz, A. Popova, Y. Zhang, C.Q. Yi, L. Pavel*, M. Yang*, Droplet-Microarray Based on Nanosensing Probe Patterns for Simultaneous Detection of Multiple HIV Retroviral Nucleic Acids, ACS Applied Materials & Interfaces, 12, 50, 55614–55623, 2020.
  • C.M. Cheng, R.L. Zhang, J.H. Wang, Y, Zhang, S.S. Xiong, Y. Huang*, M. Yang*, Porphyrinic Metal-Organic Framework Nanorod-Based Dual-Modal Nanoprobe for Sensing and Bioimaging of Phosphate, ACS Applied Materials & Interfaces, 12, 26391−26398, 2020.
  • G. Oudeng, M.T. Au, J.Y. Shi, C.Y. Wen*, M. Yang*, One-step in-situ detection of miRNA-21 expression in single cancer cells based on biofunctionalized MoS2 nanosheets, ACS Applied Materials & Interfaces, 10(1), 350-360, 2018 
  • J.H. Wang, Y.D. Fan, Y.H. Tan, X. Zhao, Y. Zhang, C.M. Cheng, M. Yang*, Porphyrinic metal–organic framework PCN-224 nanoparticles for near-infrared-induced attenuation of aggregation and neurotoxicity of Alzheimer’s amyloid-β peptide, ACS Applied Materials & Interfaces, 10(43), 36615-36621, 2018. 
  • X.Q. Su, C.Y. Chan, J.Y. Shi, M.K. Tsang, Y. Pan, C.M. Cheng, O.D. Gerile, M. Yang*, A graphene quantum dot@Fe3O4@SiO2 based nanoprobe for drug delivery sensing and dual modal fluorescence and MRI imaging in cancer cells, Biosensors and Bioelectronics. 92, 489–495, 2017
  • J.Y Shi, J. Lyu, F. Tian, M. Yang*, A fluorescence turn-on biosensor based on graphene quantum dots (GQDs) and molybdenum disulfide (MoS2) nanosheets for epithelial cell adhesion molecule (EpCAM) detection, Biosensors and Bioelectronics, 93, 182–188, 2017
  • F. Tian, J. Lyu, J.Y Shi, M. Yang* Graphene and graphene-like two-denominational materials based fluorescence resonance energy transfer (FRET) assays for biological applications, Biosensors and Bioelectronics, 89(1), 123-135, 2017
  • M.K. Tsang, W.W. Ye, G.J. Wang, J.M. Li, M Yang*, JH Hao*, Ultrasensitive detection of ebola virus oligonucleotide based on upconversion nanoprobe/nanoporous membrane, ACS Nano 10(1) 598-605, 2016.
  • J.Y. Shi, C.Y. Chan, Y.T. Pang, W.W. Ye, F. Tian, J. Lyu, Y. Zhang, M. Yang*, A fluorescence resonance energy transfer (FRET) biosensor based on graphene quantum dots (GQDs) and gold nanoparticles (AuNPs) for the detection of mecA gene sequence of Staphylococcus aureus, Biosensors and Bioelectronics 67, 595–600, 2015. 
  • J.Y. Shi, J.B. Guo, G.X. Bai, C.Y. Chan, X. Liu, W.W. Ye, J.H. Hao, S. Chen, M. Yang*, A graphene oxide based fluorescence resonance energy transfer (FRET) biosensor for ultrasensitive detection of botulinum neurotoxin A (BoNT/A) enzymatic activity, Biosensors and Bioelectronics, 65 238-244, 2015.
  • W.W. Ye, M.K. Tsang, X. Liu, M. Yang*, Jianhua Hao*, Upconversion luminescence resonance Energy Transfer (LRET)-Based Biosensor for Rapid and Ultrasensitive Detection of Avian Influenza Virus H7 Subtype, Small, 10(12), 2390–2397, 2014. 
  • B.J. Xu, W.W. Ye, Y. Zhang, J.Y. Shi, C.Y. Chan, X.Q. Yao, M. Yang*, A hydrophilic polymer based microfluidic system with planar patch clamp electrode array for electrophysiological measurement from cells, Biosensors and Bioelectronics, 53, 187-192, 2014.
  • C.Y. Hu, D. P. Yang, Z.H. Wang, P. Huang, X.S. Wang, D. Chen, D.X. Cui, M. Yang, N.Q. Jia, “Bio -mimetically synthesized Ag@BSA microspheres as a novel electrochemical biosensing interface for sensitive detection of tumor cells, Biosensors and Bioelectronics, 41, 656-662, 2013
  • K. Y., Chan, W. W. Ye, Y. Zhang, L.D. Xiao, P.H.M. Leung, Y. Li, M. Yang*, “Ultrasensitive detection of E coli O157:H7 with biofunctional magnetic bead concentration via nanoporous membrane based electrochemical immunosensor”, Biosensors and Bioelectronics, 41,532–537, 2013
  • P. Lin, F. Yan, J.J. Yu. H.L.W. Chan, M. Yang, The application of organic electrochemical transistors in cell-based biosensors, Advanced Materials, 22(33), 3655–3660, 2010.
  • Y. Zhang, M. Yang, J.H. Park, J. Singelyn, H.Q. Ma, M.J. Sailor, E. Ruoslahti, M. Ozkan, C. Ozkan, A surface charge study on cellular uptake behaviors of F3 peptide conjugated iron oxide nanoparticles, Small, 5(17), 1990-1996, 2009. 
  • Q.J. Liu, J.J. Yu, L.D. Xiao, J.C.O. Tang, Y. Zhang, P. Wang, M. Yang*, Impedance studies of bio-behavior and chemosensitivity of cancer cells by micro-electrode arrays, Biosensors and Bioelectronics, 24(5), 1305-1310, 2009. 
  • F. Yan, S.M. Mok, J.J. Yu, H.L.W. Chan, M. Yang, Label-free DNA sensor based on organic thin film transistors, Biosensors and Bioelectronics, 24(5), 1241-1245, 2009. 
  • J.J. Yu., S.K. Jha, L.D. Xiao, Q.J. Liu, P. Wang, C. Surya, M. Yang*, AlGaN/GaN heterostructures for non-invasive cell electrophysiological measurements, Biosensors and Bioelectronics, 23, 513-519, 2007.
  • Q.J. Liu, H. Cai, Y. Xu, L.D. Xiao, M. Yang, P. Wang, Detection of heavy metal toxicity using cardiac cell-based biosensor, Biosensors and Bioelectronics, 22(12), 3224-3229, 2007.
  • M. Yang, C.C. Lim, R.L. Liao, X. Zhang, A novel microfluidic impedance assay for monitoring endothelin-induced cardiomyocyte hypertrophy, Biosensors and Bioelectronics 22(8), 1688-1693, 2007.
  • Jingyu Shi, Mo Yang*, "A fluorescence resonance energy transfer (FRET) biosensor based on graphene quantum dot (GQD) and graphene oxide (GO) for detection of circulating tumour cells in vitro". the 26th Anniversary World Congress on Biosensors, , Gothenburg, Sweden, 25–27 May 2016. 
  • Jing Lyu, Mo Yang*, "A graphene quantum dot based intracellular fluorescence resonance energy transfer (FRET) assay for monitoring caspase-3 protease activity during apoptosis process in single cells". the 26th Anniversary World Congress on Biosensors, , Gothenburg, Sweden, 25–27 May 2016.
  • Xiaoqian Su, Mo Yang*, "Graphene quantum dot – magnetic nanoparticle conjugates for simultaneous dual modal imaging and drug delivery sensing based on fluorescence resonance energy transfer". the 26th Anniversary World Congress on Biosensors, , Gothenburg, Sweden, 25–27 May 2016. 
  • Jingyu Shi, Mo Yang*, "Graphene Oxide based Fluorescence Resonance Energy Transfer (FRET) Biosensor for Bacterial Protein Toxin Detection", the 24th Anniversary World Congress on Biosensors, Melbourne, Australia, May 27-30, 2014. 
  • Jingyu Shi, Mo Yang*, "Graphene Oxide based Fluorescence Resonance Energy Transfer (FRET) Biosensor for Bacterial Protein Toxin Detection", the 24th Anniversary World Congress on Biosensors, Melbourne, Australia, May 27-30, 2014. 
  • Chuanyu Chan, Mo Yang*, "Biofunctionalized graphene field effect transistor for rapid and ultrasensitive detection of H5N1 Avian Influenza Virus", the 24th Anniversary World Congress on Biosensors, Melbourne, Australia, May 27-30, 2014. 
  • WeiWei Ye, Mo. Yang*, "Nanoporous alumina membrane and nanoparticle based microfluidic sensing platform for direct DNA detection," 17th International Solid-State Sensors, Actuators and Microsystems Conference (TRANSDUCERS 2013), Barcelona, Spain, June 16-20, 2013 
  • WeiWei Ye, Mo. Yang*, "A functionalized nanoporous alumina membrane electrochemical sensor for DNA detection with gold nanoparticle amplification" Proceeding of PACRIM 10-The 10th Pacific Rim Conference on Ceramic and Glass Technology, San Diego, USA, June 2-7, 2013.
  • WeiWei Ye, Mo. Yang*, "Optimal surface functionalization of nanoporous alumina membrane for DNA detection", Materials Engineering for Advanced Technologies (ICMEAT 2012), Xiamen, China, December 27-28, 2012. Advanced Materials Research Vols. 631-632 pp 572-575, 2013. 
  • WeiWei Ye, Mo. Yang*, "Nanoparticle Enhancement for Electrochemical DNA Detection using Nanoporous Alumina Membrane", the 6th World Congress of Bioengineering (WACBE), Beijing, China, August 5-8, 2013 
  • J.H. Wang, M. Yang, “Two-dimensional nanomaterials in cancer theranostics”, Theranostic Bionanomaterials, Elsevier, ISBN: 9780128153413, 2019
  • C.S. Ozkan, M. Ozkan, M. Yang, X. Zhang S. Prasad, "Bridging Microelectronics and Biotechnology: 9 Cell Based Microarray Biosensors". Encyclopedia of Sensors, American Scientific Publishers, United States, ISBN 158883056X, Vol. 1, 401-420, 2006.
  • C.S. Ozkan, M. Ozkan, M. Yang, X. Zhang, S. Prasad, A. Morgan, "Cell Based Sensors for Chemical Detection " BioMEMS and Biomedical Nanotechnology V4: Biomolecular Sensing, Processing and Analysis, Springer, New York, ISBN 978-0-387-25561-3, 55-89, 2006.
  • M. Ozkan. C.S. Ozkan, S. Prasad, M. Yang., X. Zhang,“ Microarray and Fluidic Chip for Extracellular Sensing”, BioMEMS and Biomedical Nanotechnology V2: Micro/Nano Technologies for Genomics and Proteomics, Springer, New York, ISBN 978-0-387-25561-3, 47-98, 2006.  
  • "Multifunctional Nanoprobes for Biosensing, Imaging and Therapeutics", the 4th CIRP Conference on BioManufacturing 2019, 11-15 December, 2019, Guangzhou, China
  • "Nanparticle based fluorescence resonance energy transfer (FRET) biosensor for ultrasensitive detection", BME 2014 Biomedical Engineering International Conference, December 5, 2014, Hong Kong 
  • "Multifunctional 2D nanomaterials based nanoprobes for sensing, imaging and drug delivery", 8th WACBE World Congress on Bioengineering 2017 (WACBE 2017), August 1, 2017, Hong Kong
  • "Two-dimensional materials based nanoprobe for bioimaging and sensing", International workshop on Recent Advances in Organic Bioelectronics, June 9, 2017, Hong Kong
  • "Nanopore/nanoparticle based optical biosensor for biomolecule detection", 2nd Asia University Symposium on Biomedical Engineering, July 21, 2016, Beijing 
  • "Nanopore and nanoparticle based optical biosensor for biomolecule detection", Bioengineering in the 21st Century Symposium, Aug. 20, 2015, Hong Kong
  • "Nanoparticle based fluorescence resonance energy transfer (FRET) biosensor for ultrasensitive detection", the 4th international conference of Optofluidics 2014, August 28, 2014, Guangzhou. 
  • "Nanoparticle based fluorescence resonance energy transfer (FRET) biosensor for ultrasensitive detection", 1st Asia University Symposium on Biomedical Engineering, December 12, 2014, Taiwan 
  • "Microfluidic devices with nanopore structures for ultrasensitive foodborne pathogen detection", the 3rd international conference of Optofluidics 2013, August 15, 2013, Hong Kong
  • "Microfluidic devices with nanopore structures for ultrasensitive foodborne pathogen", Symposium of Biotechnology and Medical Instruments among Mainland, Taiwan and Hong Kong,Guangzhou, November 23, 2013. 
  • "Culturing rat mesenchymal stem cell on 2D and 3D poly(ethylene glycol) (PEG) hydrogel structure with various RGD-peptide concentrations", The 2nd International Symposium on Surface and Interface of Biomaterials (ISSIB-II),January 5th, 2010, Hong Kong
  • "Micro chip with nanostructured membranes for anti cancer drug screening using impedance spectroscopy", 10th World Congress on Biosensors, Shanghai, China, May 16th, 2008. 
  • "Multifunctional 2D nanomaterials based nanoprobes for sensing, imaging and drug delivery", invited by Zhejiang University, June 19, 2017
  • "Multifunctional 2D nanomaterials based nanoprobes for sensing, imaging and drug delivery", invited by Zhejiang Technological University, November 17, 2016
  • "Multifunctional 2D nanomaterials based nanoprobes for sensing, imaging and drug delivery", invited by Sun Yat-Sen University, August 30, 2016
  • "Microfluidic Devices Integrated with Micropore/Nanopore Structure for Bio-analytical Applications", North-eastern University, August 27, 2016
  • "Microfluidic Devices Integrated with Nanopore Structure for Foodborne Pathogen Detection", invited by Shanghai Advanced Research Institute, Chinese Academy of Sciences, January 15, 2013.
  • "Microfluidic Devices Integrated with Micropore/Nanopore Structure for Bio-analytical Applications" invited by University of Sydney, Aug 30, 2011
  • "Microfluidic Devices for Bio-analytical Applications", invited by King Abdullah University of Science and Technology, July 3, 2010
  • "Polymer Microfluidic Devices with biosensing applications", invited by Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, May 26, 2010
  • "Polymer Microfluidic Devices with biosensing applications", invited by Shanghai Advanced Research Institute, Chinese Academy of Sciences, April 16, 2010.
  • "Talk in the Television Programme of Open University of Hong Kong, for part of "Open for learning: Exploring Science: Development of Nanotechnology in Hong Kong", April 4, 2010

External Competitive Grants as Principle Investigator (PI) /Co- Principle Investigator (Co-PI)

  • Hong Kong Research Grants Council (RGC) Collaborative Research Fund (CRF), “High-resolution single-cell multi-omics: Joint profiling of multiple types of biomolecules in the same single cell”, HK$ 6,412,248 (C5005-23WF), PC, 2024-2027.
  • Hong Kong Research Grants Council (RGC) General Research Fund (GRF),  “Development of biomimic MXene-engineered exosome nanosystem for enhanced NIR-II photothermal immunotherapy with tumorassociated macrophage polarization”, (PolyU 15216622), HK$ 867,067, (PI), 2023-2025.
  • Shenzhen Science and Technology Program-Basic Research Scheme, 集成纳米传感器的微流控芯片平台用于乳腺癌来源细胞外囊泡的多维度检测,RMB 300,000 (JCYJ20220531090808020), 2022-2025.
  • Innovation Technology Fund (Guangdong-Hong Kong Technology Cooperation Funding Scheme (TCFS), “Single-cell Droplet RNA Sequencing Platform Based on DNA-encoded Nanoparticles for Pediatric Neuroblastoma Research” (GHP/032/20SZ), HK$ $2,407,400 (PI), 2022-2024
  • Hong Kong Research Grants Council (RGC) Collaborative Research Fund (CRF), “An upright multiphoton microscope for intravital imaging and optogenetic studies”, (C5078-21EF), HK$ 7,820,000, (PC), 2022-2024
  • 深港澳科技计划C, “用于新冠病毒和流感病毒现场筛查的快速检测技术和便携式微纳机电系统”, RMB 1,000,000 (PI), 2021-2023.
  • Hong Kong Research Grants Council (RGC) General Research Fund (GRF), “Multiplexed single exosome analysis based on hybridization chain reaction (HCR) enhanced multi-color fluorescence resonance energy transfer (FRET) nanoprobes in a droplet optofluidic platform”, HK$, 815,601, 2022-2024 (PolyU 15217621, PI).
  • Hong Kong Research Grants Council (RGC) Collaborative Research Fund (CRF), “Multi-level synergistic COVID-19 point-of-care diagnostics based on upconversion luminescence biosensing platform” (C5110-20G), HK$8, 408,102, 2021-2024 (Co-PI sharing HK$ 2 million)
  • Hong Kong Research Grants Council (RGC) Collaborative Research Fund (CRF), "Multi-scale spatiotemporal single-cell in-situ analysis: Mechanism and biomedical applications", (C5011-19G), HK$, 2,349,052 (Principle Coordinator) 2020-2021
  • Innovation Technology Fund (Guangdong- Hong Kong Cooperation Fund), "Development of an integrated microfluidic platform for high-throughput isolation of circulating tumor cells (CTCs) and on-chip detection of CTC-heterogeneity via multicolor nanoprobes", (GHP-039-18GD), PI, HK$1,472,500, 2020-2021
  • Hong Kong Research Grants Council (RGC) General Research Fund (GRF), "Hybrid ZnIn2S4/GQD nanointerface based artificial photoreceptors for restoring human-like colour sensitivity of degenerative retina", (PolyU 152146/19E), HK$, 869,898, 2020-2022 (PI).
  • Hong Kong Research Grants Council (RGC) General Research Fund (GRF), "A hybrid nanosystem for photo-treatment of Alzheimer’s disease in a blood-brain barrier on-a-chip", (PolyU 152108/18E), HK$, 632,421, 2019-2021 (PI).
  • Hong Kong Research Grants Council (RGC) General Research Fund (GRF), "A hybrid molybdenum disulfide (MoS2)/graphene quantum dot (GQD) nanosystem for imaging-guided combinatorial phototherapy targeting cancer stem cells", (PolyU 15216917), HK$, 443,950, 2018-2020 (PI).
  • Hong Kong Research Grants Council (RGC) General Research Fund (GRF) "A graphene quantum dot based intracellular fluorescence resonance energy transfer (FRET) assay for monitoring caspase-3 protease activity during apoptosis process in single cells", (PolyU 15221315) HK$ 845,000, 2016-2018 (PI)
  • Hong Kong Research Grants Council (RGC) General Research Fund (GRF) "A hydrophilic polymer based microfluidic patch clamp array system for simultaneous multiple cell recording", (PolyU 530511), HK$, 818,800, 2012-2015 (PI).
  • Hong Kong Research Grants Council (RGC) General Research Fund (GRF) "Simultaneous and rapid detection of multiple foodborne pathogens by nanoporous membrane based impedance arrays" (PolyU 535809), HK$ 607,000, 2010-2013 (PI).
  • Hong Kong Research Grants Council (RGC) General Research Fund (GRF) "An integrated microfluidic chip for single cell electrophysiological studies within picoliter volume", (PolyU 531607), HK$ 429,000, 2008-2010 (PI). 
  • Natural Science Foundation General Project (面上項目) (Natural Science Foundation of China (NSFC) "用於單細胞水平上檢測幹細胞內多種miRNA原位表達的多色納米感測探針的研究", (NSFC 31771077), CNY 60, 2018-2021 (PI)
  • Natural Science Foundation General Project (面上項目) (Natural Science Foundation of China (NSFC)) “基於納米孔膜的微納機電系統及其在食源性病原微生物檢測上的應用”, (NSFC 81471747), CNY 73, 2015-2018 (PI)
  • 欧登格日乐刘四喜杨莫检测SARS-CoV-2的组合物及其试剂盒和应用, China patent, CN115948609A
  • 刘宗彬,袁秀丽,陈小文,文飞球,崔秀芳,杨莫一种评估患有肿瘤或特定肿瘤风险的方法, China patent, 202211271374.8
  • 杨莫陈艳欧欧登格日乐陈俊粤一种纳米探针及其制备方法和应用、循环肿瘤细胞的miRNAs的检测系统,China patent, 202110467712.4
  • 谭又华,杨莫陈茜一种制备用于靶向肿瘤干细胞的产品的方法、产品及应用, China patent, 202110176366.4.
  • J.H. Hao, M. Yang, M.K. Tsang, W.W. Ye, “Heterogeneous Microarray Based Hybrid Upconversion nanoprobe/nanoporous membrane system”, U.S. Patent No. 10,266,403, issued on April 23, 2019.
  • K. Vafai, C.S. Ozkan, R.C. Haddon, A.R.A. Khaled, M. Yang, “Innovative biosensors for chemical and biological assays”, US Patent, No.7695951, issued on April, 13, 2010
  • K. Vafai, C.S. Ozkan, R.C. Haddon, A.R.A. Khaled, M. Yang, “Microcantilevers for biological and chemical assays and method of making and using thereof”, US Patent, No.7288404, issued on Oct, 30, 2007.
  • M. Ozkan, C.S. Ozkan, M. Yang, X. Zhang, S. Prasad, ''Biosensors having single reactant components immobilized over single electrodes and methods of making and using thereof”, US Patent, Publication No. US2006/0188904 A1 (Publication date: August 24, 2006)

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