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Academic Staff

Prof. Dongsheng Liu
PolyU Scholars Hub

Prof. Liu Dongsheng

Chair Professor of Polymer Science and Chemical Biology

Research Overview

1. New strategy for synthesizing ultra-long single stranded DNA/RNA with site-specific modifications and circular mRNAs, and their applications in chemical biology, epigenetics and medicines;
2. Supramolecular hydrogels and their applications in tissue engineering.

Education and Academic Qualifications

  • Bachelor of Science, University of Science and Technology of China
  • Master of Science, Institute of Chemistry Chinese Academy of Science
  • Doctor of Philosophy, The Hong Kong Polytechnic University

Research Interests

  • DNA
  • RNA
  • self-assembly
  • chemical modification
  • hydrogel
  • tissue engineering

Achievements

European Polymer Journal                                              Editor

Acta Polymerica Sinica                                                    Associate Editor

Chem Res Chin Univ                                                         Associate Editor

Smart Molecules                                                               Associate Editor

Secretary-General of Polymer Division, Chinese Chemical Society

  • 2005 100 Talent Program Awards of Chinese Academy of Sciences
  • 2007 Outstanding Young Scientist Funds of National Natural Science Foundation
  • 2009 The First CCS-RSC Young Scientist Award
  • 2011 Fellow of Royal Society of Chemistry (FRSC)
  • 2014 The 7th CCS-BASF Youth Innovation Prize
  • 2016 Chang Jiang Scholar Chair Professorship
  • 2016 National High-level personnel of special support program (Leading Scientist)
  • 2020 Fellow of Chinese Chemical Society (FCCS)
  1. Yujie Li†, Ruofan Chen†, Bini Zhou, Yuanchen Dong*, and Dongsheng Liu* Rational Design of DNA Hydrogels Based on Molecular Dynamics of Polymers. Adv. Mater. 36(2024), 2307129.
  2. Bini Zhou†, Bo Yang†, Qian Liu, Lu Jin, Yu Shao, Taoyang Yuan, Ya-nan Zhang Chao Wang Ziwei Shi,Xin Li, Yufan Pan, Ning Qiao, Jiang Fei Xu, Yuhe Renee Yang*, Yuanchen Dong, Lijin Xu, Songbai Gui*, and Dongsheng Liu*
    Effects of Univariate Stiffness and Degradation of DNA Hydrogels on the Transcriptomics of Neural Progenitor Cells
    J. Am. Chem. Soc., 145(16)(2023), 8954-8964.
  3. Xin Li, Xiaobin Dai, Yufan Pan, Yawei Sun, Bo Yang, Kun Chen, You Wang, Jiang-Fei Xu, Yuanchen Dong, Yuhe Renee Yang*, Li-Tang Yan, and Dongsheng Liu* Studies on the Synergistic Effect of Tandem Semi-Stable Complementary Domains on Sequence-Defined DNA Block Copolymers J. Am. Chem. Soc., 144(46)(2022), 21267-21277.
  4. Yuanchen Dong, Yang Yang, Chenxiang Lin*, and Dongsheng Liu* Frame-Guided Assembly of Amphiphiles
    Acc. Chem. Res., 55(14)(2022), 1938-1948.
  5. Xiaobin Dai†, Zhichao Zhu†, Yujie Li†, Bo Yang, Jiang-Fei Xu, Yuanchen Dong*, Xin Zhou, Li-Tang Yan*, and Dongsheng Liu* “Shutter” Effects Enhance Protein Diffusion in Dynamic and Rigid Molecular Networks J. Am. Chem. Soc., 144(41)(2022), 19017-19025.
  6. Taoyang Yuan†, Yu Shao†, Xu Zhou, Qian Liu, Zhichao Zhu, Bini Zhou, Yuanchen Dong, Nicholas Stephanopoulos, Songbai Gui*, Hao Yan*, and Dongsheng Liu* Highly Permeable DNA Supramolecular Hydrogel Promotes Neurogenesis and Functional Recovery after Completely Transected Spinal Cord Injury Adv. Mater., 33(35)(2021), 2102428.
  7. Jiezhong Shi#, Haoyang Jia#, Hao Chen, Xi Wang, Jiang-Fei Xu, Weibin Ren, Jiang Zhao, Xin Zhou, Yuanchen Dong, and Dongsheng Liu* Concentration Insensitive Supramolecular Polymerization Enabled by Kinetically Interlocking Multiple-Units Strategy CCS Chem., 1(3)(2019), 296-303
  8. Yu Shao, Haoyang Jia, Tianyang Cao, and Dongsheng Liu* Supramolecular Hydrogels Based on DNA Self-Assembly
    Acc. Chem. Res., 50(4)(2017), 659-668.
  9. Yuanchen Dong, Zhongqiang Yang, and Dongsheng Liu* DNA Nanotechnology Based on i-Motif Structures
    Acc. Chem. Res., 47(6)(2014), 1853–1860.
  10. Yuanchen Dong, Yawei Sun, Liying Wang, Dianming Wang, Tao Zhou, Zhongqiang Yang, Zhong Chen, Qiangbin Wang, Qinghua Fan, and Dongsheng Liu* Frame-Guided Assembly of Vesicles with Programmed Geometry and Dimensions
    Angew. Chem. Int. Ed., 53(10)(2014), 2607-2610.

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