Academic Staff

PolyU Scholars Hub

Dr Poon Chui-wa, Christina

Research Fellow

Y817-09
+852 3400 8746
christina.poon@polyu.edu.hk

PolyU Scholars Hub

ORCID ID

SCOPUS ID

Research Overview

The focus of my research area is to study the use and underlying mechanisms of Chinese herbal medicine for improving musculoskeletal health and the management of aging-related musculoskeletal disorders.

Research Interests

Achievements

Yu WX, Poon CCW, Zhou LP, Wong KY, Cao S, Lam CY, Lee WYW, Wong MS (2024). Oleanolic acid exerts bone anabolic effects via activation of osteoblastic 25-hydroxyvitamin D 1-alpha hydroxylase. Biomedicine & Pharmacotherapy. 173:116402. doi: 10.1016/j.biopha.2024.116402.
Wong KY, Kong TH, Poon CCW, Yu WX, Zhou L, Wong MS (2023). Icariin, a phytoestrogen, exerts rapid estrogenic actions through crosstalk of estrogen receptors in osteoblasts. Phytother Res. doi: 10.1002/ptr.7939.
Zhang JL, Du C, Poon CCW, He MC, Wong MS, Wang NN, Zhang Y (2023). Structural characterization and protective effect against renal fibrosis of polysaccharide from Ligustrum lucidum Ait. J Ethnopharmacol. 302(Pt A):115898. doi: 10.1016/j.jep.2022.115898.
Xiao HH, Zhu YX, Lu L, Zhou LP, Poon CCW, Chan CO, Wang LJ, Cao S, Yu WX, Wong KY, Mok DK, Wong MS (2022). The Lignan-Rich Fraction from Sambucus williamsii Hance Exerts Bone Protective Effects via Altering Circulating Serotonin and Gut Microbiota in Rats. Nutrients. 14(22):4718. doi: 10.3390/nu14224718.
Zhang JL, Poon CCW, Wong MS, Li WX, Guo YX and Zhang Y (2022). Vitamin D Supplementation Improves Handgrip Strength in Postmenopausal Women: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Front. Endocrinol. doi: 10.3389/fendo.2022.863448.
Zhou LP, Wong KY, Poon CCW, Yu WX, Xiao HH, Chan CO, Mok DKW and MS Wong (2022). Water extract of Rhizoma Drynaria selectively exerts estrogenic activities in ovariectomized rats and estrogen receptor-positive cells. Front. Endocrinol. doi: 10.3389/fendo.2022.817146.
Yu WX., Poon CCW, Lee WYW and Wong MS (2021). Oleanolic Acid Modulates 25-Hydroxyvitamin D3 1-alpha-hydroxylase in Osteoblasts and Human Mesenchymal Stem Cells. Journal of the Endocrine Society, 5(Suppl 1), A237. doi: 10.1210/jendso/bvab048.482.
Li WX, Qin XH, Poon CCW, Wong MS, Feng R, Wang J, Lin FH, Sun YL, Liu SF, Wang YJ and Zhang Y (2021). Vitamin D/Vitamin D Receptor Signaling Attenuates Skeletal Muscle Atrophy by Suppressing Renin-Angiotensin System. Journal of Bone and Mineral Research. doi: 10.1002/jbmr.4441.
Wong KY, Zhou LP, Yu WX, Poon CCW, Xiao HH, Chan CO, Mok DKW and Wong MS (2021). Water extract of Er-xian decoction selectively exerts estrogenic activities and interacts with SERMs in estrogen-sensitive tissues. J Ethnopharmacol. 275:114096. doi: 10.1016/j.jep.2021.114096.
Xiao HH, Lu L, Poon CCW, Chan CO, Wang LJ, Zhu YX, Zhou L, Cao S, Yu W, Wong KY, Mok DKW and Wong MS (2021). The lignan-rich fraction from Sambucus Williamsii Hance ameliorates dyslipidemia and insulin resistance and modulates gut microbiota composition in ovariectomized rats. Biomedicine & Pharmacotherapy. 137:111372. doi: 10.1016/j.biopha.2021.111372.
Zhou L, Poon CCW*, Wong KY, Cao S, Dong X, Zhang Y and Wong MS (2021). Icariin ameliorates estrogen-deficiency induced bone loss by enhancing IGF-I signaling via its crosstalk with non-genomic ERα signaling. Phytomedicine. 82:153413. doi: 10.1016/j.phymed.2020.153413.
Zhou L, Wong KY, Yu X, Poon CCW, Xiao HH, Chan CO, Mok DKW, Zhang Y and Wong MS (2021). Selective Estrogen Receptor Modulator-Like Activities of Herba epimedii Extract and its Interactions With Tamoxifen and Raloxifene in Bone Cells and Tissues. Frontiers in Pharmacology. 11:571598. doi: 10.3389/fphar.2020.571598.
Sha NN, Zhang JL, Poon CCW, Li WX, Li Y, Wang YF, Shi W, Lin FH, Lin WP, Wang YJ and Zhang Y (2020). Differential responses of bone to angiotensin II and angiotensin(1-7): beneficial effects of Ang(1-7) on bone with exposure to high glucose. Am J Physiol Endocrinol Metab. doi: 10.1152/ajpendo.00158.2020.
Zhou L, Wong KY, Cao S, Poon CCW, Yu X, Dong XL, Tsim KWK and Wong MS (2021). A standardized extract of Danggui Buxue Tang decoction selectively exerts estrogenic activities distinctly from tamoxifen. Phytotherapy Research. 35(3):1456-1467.doi: 10.1002/ptr.6909.
Qiu ZC, Zhang Y, Xiao HH, Poon CCW, Li XL, Cui JF, Wong MK, Yao XS and Wong MS (2020). 8-prenylgenistein exerts osteogenic effects via ERα and Wnt-dependent signaling pathway. Experimental Cell Research. 395(1):112186. doi: 10.1016/j.yexcr.2020.112186.
Zhou L, Poon CCW*, Wong KY, Cao S, Yu W, Dong X, Lee WY, Zhang Y and Wong MS (2019). Prenylflavonoid Icariin Induces Estrogen Response Element-Independent Estrogenic Responses in a Tissue-Selective Manner. Journal of the Endocrine Society. 4(2):bvz025. doi: 10.1210/jendso/bvz025.
Wong MS, Poon CCW, Zhou LP and Xiao HH (2019). Natural Products as Potential Bone Therapies. Handbook of experimental pharmacology. doi: 10.1007/164_2019_322.
Ho MX, Poon CCW*, Wong KC, Qiu ZC and Wong MS (2018). Icariin, but Not Genistein, Exerts Osteogenic and Anti-apoptotic Effects in Osteoblastic Cells by Selective Activation of Non-genomic ERα Signaling. Frontiers in Pharmacology. 9:474. doi: 10.3389/fphar.2018.00474.