Academic Staff
- Y801
- +852 3400 8673
- sibao.chen@polyu.edu.hk
ORCID ID
SCOPUS IDResearch Overview
Our group is interested in drug discovery and development of functional food & dietary supplements from natural resources and Traditional Chinese Medicine.
Education and Academic Qualifications
- Doctor of Philosophy, Peking Union Medical College & Chinese Academy of Medical Science
Research Interests
Achievements
- 《藥用植物親緣學理論創新與應用實踐》獲得2020年度中華中醫藥學會科學技術獎一等獎, 北京
- 蟾毒靈膠束納米製劑及其製備方法，專利號 ZL 2017 1 0028050.4
- 治療鼻咽癌的藥物組合物，專利號：ZL 2018 1 1049043.3
- 具有抗腫瘤活性的兩個新阿撲菲－苄基異喹啉化合物，專利號CN00103296.8
- 一個新聯苯環辛烯木脂素及其製備方法和用途，專利號CN200410096776.4
- 一個新穎的類木脂素及其製備方法和用途，專利號 CN200510073256.6
- 一種聯苯環辛二烯木脂素在製備抗腫瘤藥物的用途，專利號 N200410077286.X
- Gong Ruihong, Chen Jiawen, Shen Lisha, Lin Yushan, Yu Haiyang, Chen Sibao*, Chen Guoqing*. Assessing the therapeutic potential of Elephantopus scaber extract in hepatocellular carcinoma by inhibiting the PI3K-Akt pathway. Journal of Functional Foods 2024; 113:106009.
- Lin Yushan, Sun Zhiwei, Shen Lisha, Gong Ruihong, Chen Jiawen, Xu Yanfeng, Yu Haiyang, Chen Sibao*, Chen Guoqing*. Arnicolide D induces endoplasmic reticulum stress-mediated oncosis via ATF4 and CHOP in hepatocellular carcinoma cells. Cell Death Discovery 2024; 10:134.
- Magnolia Muk-Lan Lee, Brandon Dow Chan, Wing-Yan Wong, Zhao Qu, Man-Sum Chan, Tsz-Wing Leung, Yushan Lin, Daniel Kam-Wah Mok, Sibao Chen*, William Chi-Shing Tai*. Anti-cancer Activity of Centipeda minima Extract in Triple Negative Breast Cancer via Inhibition of AKT, NF-kB, and STAT3 Signaling Pathways. Fronts in Oncology 2020, 10: 491.
- Tao Su, Ya-Ping Wang, Xin-Ning Wang, Chun-Yu Li, Pei-Li Zhu, Yu-Mei Huang, Zhi-Ye Yang, Si-Bao Chen*, Zhi-Ling Yu*. The JAK2/STAT3 pathway is involved in the anti-melanoma effects of brevilin A. Life sciences 2020, 241: 117169.
- Qiuyue Lv, Liang Le, Jiamei Xiang, Baoping Jiang*, Sibao Chen*, Peigen Xiao. Liver Transcriptomic Reveals Novel Pathways of Empagliflozin Associated With Type 2 Diabetic Rats. Front Endocrinol 2020; 11: 111.
- Zhu P, Zheng Z, Fu X, Li J, Yin C, Chou J, Wang Y, Liu Y, Chen Y, Bai J, Wu J, Chen SB*, Yu ZL*. Arnicolide D exerts anti-melanoma effects and inhibits the NF-κB pathway. Phytomedicine 2019; 64: 153065.
- Chi-on Chan, Xiu-juan Xie, Siu-wai Wan, Gao-li Zhou, Ailsa Chui-ying Yuen, Daniel Kamwah Moka*, Si-bao Chen*. Qualitative and quantitative analysis of sesquiterpene lactones in Centipeda minima by UPLC–Orbitrap–MS & UPLC-QQQ-MS. J Pharm Biomed Anal. 2019;147: 360-366.
- Mengxun Zhang, Magnolia Muk-Lan Lee, Weijian Ye, Wing-Yan Wong, Brandon Dow Chan, Sibao Chen,* Lizhi Zhu,* William Chi-Shing Tai,* Chi-Sing Lee*. Total Synthesis-Enabled Systematic Structure−Activity Relationship Study for Development of a Bioactive Alkyne-Tagged Derivative of Neolaxiflorin L. J Organic Chem 2019; 84 (11): 7007-7016.
- Rui Liu, Zhao Qu, Yushan Lin, Chi-Sing Lee*, William Chi-Shing Tai*, Sibao Chen*. Brevilin A induces Cell Cycle Arrest and Apoptosis in Nasopharyngeal Carcinoma. Frontier Pharmacology 2019, 10:594.
- Qiuyue Lv, Yushan Lin, Zhexu Tan, Baoping Jiang, Lijia Xu, Haiqin Ren, William Chi-shing Tai, Chi-on Chan, Chi-sing Lee, Zhengbing Gu, Daniel KW Mok*, Sibao Chen*. Dihydrochalcone-derived polyphenols from tea crab apple (Malus hupehensis) and their inhibitory effects on α-glucosidase in vitro. Food & Function 2019; 10: 2881-2887.
- Jing Jing, Karnaker R. Tupally, Ganesh R. Kokil, Zhi Qu, Sibao Chen*, Harendra S. Parekh*. Development of a hybrid peptide dendrimermicellar carrier system and its application in the reformulation of a hydrophobic therapeutic agent derived from Traditional Chinese Medicine. RSC Advances 2019; 9: 2458–2463.
- Haiyan Sun, Maohua Huang, Nan Yao, Jianyang Hu, Yingjie Li, Liping Chen, Nan Hu, Wencai Ye, William Chi-Shing Tai, Dongmei Zhang*, Sibao Chen*. The cycloartane triterpenoid ADCX impairs autophagic degradation through Akt overactivation and promotes apoptotic cell death in multidrug-resistant HepG2/ADM cells. Biochem Pharmacol 2017; 146: 82-100.
- Guo DJ, Xu LJ, Cao XW, Guo YQ, Ye Y, Chan CO, Mok DK, Yu ZL, Chen SB*. Anti-inflammatory activities and mechanisms of action of the petroleum ether fraction of Rosa multiflora Thunb. hips. J Ethnopharmacol 2011; 138 (3): 717-22.
- Si-Bao Chen, He-Ping Liu, Run-Tao Tian, Da-Jian Yang, Shi-Lin Chen, Hong-Xi Xu, Albert S.C. Chan, Pei-Shan Xie. High-performance thin-layer chromatographic fingerprints of isoflavonoids for distinguishing between Radix Puerariae Lobate and Radix Puerariae Thomsonii. Journal of Chromatography A 2006; 1121: 114–119.
- Si-Bao Chen*; Guang-Yao Gao; Hei-Wun Leung; Hin-Wing Yeung; Jun-Shan Yang; Pei-Gen Xiao.Aquiledine and Isoaquiledine, Novel Flavonoid Alkaloids from Aquilegia ecalcarata, J. Nat. Prod 2001; 64: 85.
- Handbook of Active Constituents from Chinese Materia Medica & Phytomedicine, Commercial Press, Hong Kong, 2002
- Heath Food Research and Development from Chinese Traditional Medicine《中藥保健食品研製與開發》, People's Health Press, Beijing, 2002
- 《中藥資源可持續利用導論》(Introduction to the sustainable Utilization of Chinese Herbal Medicine Rresources) , 中國醫藥科技出版社，北京：2006年
- 《中藥材品質專論》，（Monographs for Quality Evaluation of Chinese Crude Drugs）,上海科技出版社，上海：2013年1月
