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Prof. Sheng Chen
PolyU Scholars Hub

Prof. Chen Sheng

Head (FSN) & Chair Professor of Microbiology

PolyU Scholars Hub
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Research Overview

Prof. Chen’s current research covers research on bacterial antimicrobial resistance, virulence and tolerance in the veterinary, food and medical microbiology fields. His research lies on the interface of clinical study and basic science using multi-disciplinary approaches including Genomics, Genetics, Biochemistry, Cell Biology and Chemical Biology with the ultimate goal of developing novel therapies to combat bacterial antimicrobial resistance

Education and Academic Qualifications

  • Bachelor of Science in Agriculture, China Agricultural University
  • Master of Science in Agriculture, China Agricultural University
  • Doctor of Philosophy, University of Maryland

Academic and Professional Experience

  • 2023.3-Present     Director, Shenzhen Key lab for Food Biological Safety Control, The Hong Kong PolyU Shenzhen Research Institute, Shenzhen, China

  • 2021.6-Present     Member of Advisory Council on Food and Environmental Hygiene, Food and Health Bureau, Hong Kong Government

  • 2022.6-Present     Member of Expert Committee on Antimicrobial Resistance, Centre for Health Protection, Hong Kong Government

  • 2022.6-Present     Admission Panel members for Incubation Programmes, Hong Kong Science and Technology Parks Corporation (HKSTP)

  • 2020-2023     Professor and Associate Dean, College of Veterinary Medicine and Life Science, City University of Hong Kong

  • 2020-2023     Director, Animal Health Research Center, Chendu Research Institute, City University of Hong Kong, Chendu, China

  • 2019-2020     Professor and Acting Head, Department of Infectious Diseases and Public Health, College of Veterinary Medicine and Life Science, City University of Hong Kong

  • 2017-2019     Professor, Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong

  • 2014-2017     Associate Professor, Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong

  • 2009-2014     Assistant Professor, Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong

  • 2004-2009     Post-doctoral Fellow, Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI, USA

  • 2012-2019      Distinguished Professor, The Hong Kong PolyU Shenzhen Research Institute, Shenzhen, P. R. China

  • 2015-2019     Director, Shenzhen Key lab for Food Biological Safety Control, The Hong Kong PolyU Shenzhen Research Institute, Shenzhen, China

  • 2015-2017     Chairman, Animal Subject Ethics Sub-Committee, The Hong Kong Polytechnic University, Hong Kong

  • 2015-2019     Director, Central Animal Facility, The Hong Kong PolyU Shenzhen Research Institute, Shenzhen, China

  • 2010-2019     Associate Director, Food Safety and Technology Research Center, The Hong Kong Polytechnic University, Hong Kong

  • 2010-2011     Ad Hoc working group on the microbial guidelines for ready-to-eat food, Food Safety Center, Department of Food and Environmental Hygiene, Hong Kong

  • 2010-2016     Shenzhen Expert Committee on pharmacology and biotechnology, Shenzhen, China

Research Interests

  • Bacterial AMR
  • Bacterial pathogenesis
  • Bacterial tolerance
  • Novel antimicrobial drug discovery
  • Vaccine and monoclonal antibody therapy development
  • Genomics and metagenomics
  • One Health research

Achievements

  • Fellow of American Academy of Microbiology 
  • Stanford's top 2% most highly cited scientists 2023 
  • Stanford's top 2% most highly cited scientists 2022 
  • Outstanding Research Award 2022, City University of Hong Kong 
  • Stanford's top 2% most highly cited scientists 2021 
  • Engineering Botulinum Neurotoxin. US Patent Serial No. 61/169,031, (2011). EU Patent Serial No. 20120039941 (2012), licensed by Syntaxin Ltd. Oxon, UK in 2012. 
  • Engineering botulinum neurotoxin with elevated activity. US patent provisional No. 61868560. PCT/CN2014/084725 
  • Method to develop fluorescent labelled E. coli capable of colonization in animal GI tract, China patent: 201410462647.6 
  • Methods to develop non-fluorescent labelled, tracable E. coli, China patent: 201410461450.0 
  • Development of combinational therapy based on different serotypes of BoNT, China patent: 201510306128.5 
  • Potent peptide-based inhibitors against BoNT/A, China patent: 201510623351.2 
  • A test strip for detecting broad spectrum Salmonella in food and preparation thereof, China patent: 201711351523.0 
  • A toxin sensor based on an organic photoelectrochemical transistor and a preparation method thereof, China patent: 201711464221.4 
  • A biosensor for Norovirus detection and its preparation and use, China patent: 201711351548.0 
  • A biosensor for detection of Salmonella and its preparation and use, China patent: 201711348592.6 
  • HKU/ref: IP00761 (PolyU ref: PAT-1139): New cyclic peptided-based antibacterial agent.  
  • United States provisional application 62/642,080, filed on March 13, 2018: Repurposing cetylpyridinium chloride and domiphen bromide as phosphoethanolamine transferase inhibitor-based adjuvants that significantly potentiate colistin activity and resensitize mcr-1-bearing bacterial pathogens 
  • United States Provisional Application Number 62/642,053, filed on March 3, 2018: 1,2-BENZISOSELENAZOL-3(2H)-ONE derivatives as carbapenem antibiotic adjuvants 
  • DRUG COMPOSITION, METHOD FOR TREATING INFECTION, DISINFECTING COMPOSITION, AND DRUG ADJUVANT (Non-Provisional Patent Application: PWG/PA/1135/12/2021 (US)) 
  • DEVELOPMENT OF SYNTHETIC PSEUDAMINIC ACID-BASED ANTIBACTERIAL VACCINES AGAINST ACINETOBACTER BAUMANNII (PCT/63/260,512) 
  • 一种治疗耐碳青霉烯肺炎克雷伯氏菌感染的组合物(CB/P24320CNOO, 202210655492.2) 
  • METHODS FOR TREATING BACTERIAL CELL POPULATIONS (PCT /CN2021 /099665), 2021.06.11 
  • 新型抗生素及其使用方法, 201880090658 .2/ PCT/CN2018/122374 2018 .12 .20, 2018.01.03 
  1. The Lancet Infectious Diseases. 2022 Jul;22(7):939.; 2022 Feb;22(2):167-168; 2018 Jan;18(1):37-46; 2018 Jan;18(1):24; 2018 Jan;18(1):25; 2017 Mar;17(3):256-257, 2016 Mar;16(3):291-2. 
  2. Signal Transduct Target Ther. 2023 May 30;8(1):221. 
  3. The Lancet Microbe. 2022 Apr;3(4):e248; 2022 Nov;3(11):e846-e856; 2022 Nov 24:S2666-5247(22)00326-3. 
  4. Nature Microbiology. 2019 Dec;4(12):2039-2043.  
  5. Journal of Infection. 2022 Aug;85(2):174-211; 2022 Oct;85(4):436-480. 
  6. Drug Resist Updates. 2023 Jan 11;67:100925. 
  7. ACS Central Science. 2024-02-07 DOI: 10.1021/acscentsci.3c01507; 2021 Sep 22;7(9):1535-1542. 
  8. Journal of the American Chemical Society. 2021 Aug 18;143(32):12784-12790. 
  9. Angewandte Chemie-International Edition. 2020 Nov 2;59(45):19868-19872. 
  10. Nature Communications. 2020 Sep 16;11(1):4648; 2016 Aug 3;7:12394. 
  11. Eurosurveillance, 2023 Sep;28(37). 2019 Mar;24(13):1800113; 2017 Sep;22(39):17-00206. 
  12. Emerg Microbes Infect. 2024 Jan 19:2306957; 2022 Dec;11(1):841-849; 2022 Dec;11(1):1730-1741; 2022 Dec;11(1):1049-1057; 2020 Dec;9(1):1287-1299; 2020 Jan 29;9(1):237-245; 2019;8(1):396-403; 2019;8(1):857-865; 2018 Jul 9;7(1):127. 
  13. Int J Antimicrob Agents. 2023 Dec 9;63(2):107055. 2022 Jan;59(1):106498; 2018 Apr;51(4):578-585; 2022 Aug;60(2):106628; 2022 Nov-Dec;60(5-6):106683; 2022 Oct;60(4):106645; 2020 Jan;55(1):105817; 2016 Jan;47(1):103-5; 2018 Aug;52(2):303-304; 2015 Jun;45(6):667-8. 
  14. eBioMedicine. 2024 Feb 9;101:104998. 2022 May;79:103998;  2017 May;19:98-106. 
  15. Trends in Microbiology. 2021 Jan;29(1):65-83. 
  16. J Hazard Mater. 2023 Jan 4;446:130725. 
  17. Proceedings of the National Academy of Sciences of the United States of America. 2020 Mar 10;117(10):5260-5268. 
  18. Gut Microbes. 2020 Nov 9;12(1):1-12.  
  19. ACS Applied Materials & Interfaces. 2022 Jul 20;14(28):31727-31736. 
  20. Sci Total Environ. 2024 May 20;926:171924.  2024 Apr 15;921:170903.  2024 Mar 15;916:170058. 2024 Jan 1;906:167373.  2023 Dec 1;902:166026.  2023 Sep 1;889:164302. 2022 Apr 20;818:151767.   
  1. Chen, S., Barbieri, J.T. Light Chains of the Botulinum neurotoxins. Neurotoxin. Edited by Keith Foster, Springer, CO, UK, 2013. 
  2. Chen, S. Clostridial Neurotoxins as therapeutics. Microbial Toxins-Genetics, Molecular Biology and Novel Applications. Edited by Thomas Proft, The Horizon Scientific Press, UK 2013.
     

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