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Prof. Man-kin Wong
PolyU Scholars Hub

Prof. Wong Man-kin

Associate Dean (FS) & Professor

Research Overview

Our research group uses Synthetic Chemistry as a core technology to address problems in Chemistry, Chemical Biology and Food Safety.

Education and Academic Qualifications

  • Bachelor of Science, The University of Hong Kong
  • Doctor of Philosophy, The University of Hong Kong

Research Interests

  • Catalysis
  • Bioconjugation
  • Molecular Imaging
  • Food Safety

Achievements

  • Asian Core Program Lectureship Awards: 2011 (Japan), 2014 (China), 2014 (Thailand), 2016 (Korea), and 2016 (Taiwan)
  • Method and Kit for Detecting Formaldehyde in Food based on Metal Catalysis Coupling Reaction.
    Da-Peng Xiang, Man-Kin Wong, Ching Liu, Xiao-Qun Wei, Ka-Hing Wong, Kong-Fan Wong and Shi-Ping Shao
    CN 104193672 A
  • Chiral Gold(III) Complexes Preparation and Applications.
    Man-Kin Wong and Jian-Fang Cui
    201610860285.5
  • New Quinolizinium Dyes Preparation and Application on Photoredox Catalysis.
    Man-Kin Wong, Jieren Deng and Chun Him Nathanael Lai
    201610915159.5
  1. O WY, Cui JF, Yu Q, Kung KKY, Chung SF, Leung YC, Wong MK. Isoindolium-Based Allenes: Reactivity Studies and Applications in Fluorescence Temperature Sensing and Cysteine Bioconjugation. Angewandte Chemie - International Edition. 2023, 62, e2022180. 
  2. Ajcharapan T, Kung KKY, Chan WC, Deng JR, Ko BCB, Wong MK. Quinolinium-based Viscosity Probes for Lysosome Imaging and Tracing Lysosomal Viscosity Changes in Living Cells. Sensors and Actuators B: Chemical, 2022, 367, 132003. 
  3. Sit HY, Deng JR, Chan WC, Ko BCB, Wong MK. Quinolizinium-based Tunable pH Fluorescent Probes for Imaging in Live Cells. Dyes and Pigments, 2022, 205, 110541. 
  4. Deng JR, Lai NCH, Kung KKY, Yang B, Chung SF, Leung ASL, Choi MC, Leung YC, Wong MK. N-Terminal Selective Modification of Peptides and Proteins using 2-Ethynylbenzaldehydes. Communications Chemistry, 2020, 3(1), 67. 
  5. Deng JR, Chung SF, Leung, ASL, Yip WM, Yang B, Choi MC, Cui JF, Kung KKY, Zhang Z, Lo KW, Leung YC, Wong MK. Chemoselective and Photocleavable Cysteine Modification of Peptides and Proteins using Isoxazoliniums. Communications Chemistry. 2019; 2(1): 93. 
  6. Sit HY, Yang B, Kung KKY, Tam JS-L, Wong MK. Fluorescent Labelling of Glycans with FRET-Based Probes in a Gold(III)-Mediated Three-Component Coupling Reaction. ChemPlusChem. 2019; 84(11):173943. 
  7. Jiang JJ, Cui JF, Yang B, Ning Y, Lai NCH, Wong MK. Chiral Cyclometalated Oxazoline Gold(III) Complex-Catalyzed Asymmetric Carboalkoxylation of Alkynes. Organic Letters. 2019; 21(16): 6289-94. 
  8. Deng JR, Chan WC, Chun-Him Lai N, Yang B, Tsang CS, Chi-Bun Ko B, Lai-Fung Chan S, Wong MK. Photosensitizer-free Visible Light-mediated Gold-catalysed cis-Difunctionalization of Silyl-substituted Alkynes. Chemical Science. 2017;8(11):7537-44. 
  9. Cui JF, Ko HM, Shing KP, Deng JR, Lai NCH, Wong MK. C,O-Chelated BINOL/Gold(III) Complexes: Synthesis and Catalysis with Tunable Product Profiles. Angewandte Chemie - International Edition. 2017;56(11):3074-9. 
  10. Kung KKY, Ko HM, Cui JF, Chong HC, Leung YC, Wong MK. Cyclometalated Gold(III) Complexes for Chemoselective Cysteine Modification via Ligand Controlled C—S Bond-forming Reductive Elimination. Chemical Communications. 2014;50(80):11899-902. 
  1. Book Chapter Title: Asymmetric Epoxidation Catalyzed by Chiral Ketones.
    Man Kin Wong, Yiu Chung Yip and Dan Yang
    In the book "Asymmetric Catalysis from Chinese Perspective"
    Springer, 2011
    Editor: Prof. Shengming Ma

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