Academic Staff

PolyU Scholars Hub

Dr Alex CHEUNG

Lecturer

BSc (HKBU), MPhil (CUHK), PhD (UCL)

ST516
+852 2766 7144
alexkk.cheung@polyu.edu.hk

PolyU Scholars Hub

ORCID ID

SCOPUS ID

Biography

Dr. Cheung obtained his BSc in Applied Biology at the Hong Kong Baptist University and his MPhil in Basic Medical Sciences at the Chinese University of Hong Kong, during which he worked extensively on cancer biology. After receiving his PhD in Neuroscience at University College London, he pursued his first postdoctoral training at the Victor Chang Cardiac Research Institute in Sydney studying the renewal mechanisms of skeletal muscle stem cells. He also worked as a postdoctoral fellow at the Chinese University of Hong Kong, focusing on developmental neuroscience and myogenesis before joining the Hong Kong Polytechnic University.

Alex is interested in dynamic gene expression pattern during different stages of cell differentiation and maturation, pathophysiology of tissue injury as well as mechanisms during tissue regeneration. He is currently working closely with academic staff on basic science research.

Education and Academic Qualifications

Bachelor of Science in Applied Biology, Hong Kong Baptist University
Master of Philosophy, The Chinese University of Hong Kong
Doctor of Philosophy, University College London (University College London)

Research Interests

Research Output

Fung TK*, Cheung KK*, Wang X, Lau BWM, Ngai SPC. (2024) Transcriptomic Profiling Reveals Differences in Slow Twitch and Fast Twitch Muscles of a Cigarette Smoke-Exposed Rat Model. J Cachexia Sarcopenia Muscle. https://doi.org/10.1002/jcsm.13633

Lui K, Cheung KK, Ng WW, Wang Y, Au DWH, Cho WC. (2024) Genetic Mutations and Advances in Immunotherapy for Lung Cancer Treatment. Int J Mol Sci. 25(22), 11954. https://doi.org/10.3390/ijms252211954

Tam SY, Chung SF, Kim CF, To JC, So PK, Cheung KK, Chung WH, Wong KY, Leung TYC. (2023) Development of a bioengineered Erwinia chrysanthemi asparaginase to enhance its anti-solid tumor potential for treating gastric cancer. Int J Biol Macromol. 253(Pt 5):127742. https://doi.org/ 10.1016/j.ijbiomac.2023.127742

Lui K, Huang Y, Sheikh S, Cheung KK, Tam WY, Sun KT, Cheng KM, Ng WWM, Loh AWK. (2023) The oncogenic potential of Rab-like protein 1A (RBEL1A) GTPase: a mini review. J Cancer 14(17):3214-26. https://doi.org/10.7150/jca.84267

Zhou SJ, Cheing GLY^#, Cheung AKK^#. (2022) Role of exosomes, exosomal microRNA, in muscle-kidney crosstalk in chronic kidney disease. Front Cell Dev Biol 10:951837. https://doi.org/10.3389/fcell.2022.951837

He AWJ, Ngai SPC^#, Cheung KK^#, Lau BWM^#, Sánchez-Vidaña DI, Pang MYC. (2022) Impacts of cigarette smoke (CS) on muscle derangement in rodents – a systematic review. Toxics 10:262. https://doi.org/10.3390/toxics10050262

Chen H, Siu SWI, Wong CTT, Qiu J, Cheung AKK^#; Lee S^#. (2022) Anti-epileptic Kunitz-like peptides discovered in the branching coral Acropora digitifera through transcriptomic analysis". Arch Toxicol 96(9):2589-2608. https://doi.org/10.1007/s00204-022-03311-4

Wang X; Liao Q, Chen H, Gong G, Siu SWI, Chen Q, Kam HT, Ung COL, Cheung KK, Rádis‑Baptista G, Wong CTT and Lee SMY. (2021) Toxic peptide from Palythoa caribaeorum acting on the TRPV1 channel prevents pentylenetetrazol-induced epilepsy in zebrafish larvae. Front Pharmacol 12:763089. https://doi.org/10.3389/fphar.2021.763089

Kannan P, Cheung KK, Lau BWM, Li L, Chen H and Sun F. (2021) A mixed-methods study to evaluate the effectiveness and cost-effectiveness of aerobic exercise for primary dysmenorrhea: A study protocol. PLoS One https://doi.org/10.1371/journal.pone.0256263
Yu KKK, Cheing GLY, Cheung C, Kranz GS, Cheung AKK. (2021) Gray matter abnormalities in type 1 and type 2 diabetes: a dual disorder ALE quantification. Front Neurosci 15:638861. https://doi.org/10.3389/fnins.2021.638861.
Chen H, Luo C, Ai G, Wang Y, Li C, Tan L, Lee SMY, Cheung AKK, Su Z, Xie J*, Wu X* and Zeng H*. (2021) A comparative investigation of the interaction and pharmacokinetics of hemoglobin with berberine and its oxymetabolite. J Pharm Biomed Anal 199:114032. https://doi.org/10.1016/j.jpba.2021.114032
Choi HMC, Cheung AKK, Ng MCH, Zheng YP, Jam YK, Cheing GLY. (2021) Indentation stiffness measurement by an optical coherence tomography-based air-jet indentation system can reflect type I collagen abundance and organisation in diabetic wounds. Front Bioeng Biotechnol 9:648453. https://doi.org/10.3389/fbioe.2021.648453
Tam WY, Wang X, Cheng ASK, Cheung KK^#. (2021) In search of molecular markers for cerebellar neurons. Int J Mol Sci 22:1850. https://doi.org/10.3390/ijms22041850
Leung JWH, Cheung KK, Ngai SPC, Tsang HWH and Lau BWM. (2020) Protective effects of melatonin on neurogenesis impairment in neurological disorders and its relevant molecular mechanisms. Int J Mol Sci 21:5645. https://doi.org/10.3390/ijms21165645
Tam WY and Cheung KK^#. (2020) Phenotypic characteristics of commonly used inbred mouse strains. J Mol Med 98:1215-1234. https://doi.org/10.1007/s00109-020-01953-4
Zhang EW, Li-Tsang CWP, Li TMH, Huang L and Cheung KK. (2020) Smart Scar Care Pad (SSCP) – an innovated silicone-based insert that improved severe hypertrophic scar by integrating optimal pressure and occlusion effects. Adv Wound Care 9(10):564-575. https://doi.org/10.1089/wound.2019.1016
Cheung KK*, Fung TKH*, Mak JCW, Cheung SY, He WJ, Leung JWH, Lau BWM and Ngai SPC. (2020) The acute effects of cigarette-smoke exposure on muscle fiber type dynamics in rats. PLoS One 15(5):e0233523. https://doi.org/10.1371/journal.pone.0233523
Choi HMC, Cheung AKK, Ng GYF and Cheing GLY. (2018) Effects of pulsed electromagnetic field (PEMF) on the tensile biomechanical properties of diabetic wounds at different phases of healing. PLoS One 13(11):e0208475. https://doi.org/10.1371/journal.pone.0208475
Sun KT, Cheung KK, Au SWN, Yeung SS and Yeung EW. (2018) Overexpression of mechano-growth factor modulates inflammatory cytokine expression and macrophage resolution in skeletal muscle injury. Front Physiol 9:999 https://doi.org/10.3389/fphys.2018.00999
Yeung EW, Cheung KK, Sun KT. (2017) Biological Role of TRPC1 in myogenesis, regeneration and disease. In ‘The Plasticity of Skeletal Muscle—From Molecular Mechanism to Clinical Applications” Ed by Sakuma K. Springer Singapore. https://doi.org/ 10.1007/978-981-10-3292-9_10
Yang BR*, Cheung KK*, Zhou X, Xie RF, Chen PP, Wu S, Zhou ZY, Tang JY, Hoi PM, Wang YH and Lee SMY. (2016) Amelioration of acute myocardial infarction by saponins from flower buds of Panax notoginseng via pro-angiogenesis and anti-apoptosis. J Ethnopharmacol 181:50-8. https://doi.org/10.1016/j.jep.2016.01.022 (*co-first authors)
Xia L, Cheung KK, Yeung SS and Yeung EW. (2016) The involvement of TRPC1 in skeletal muscle regrowth after unloading-induced atrophy. J Physiol (London) 594:3111-26. https://doi.org/10.1113/JP271705

*Co-first author; # corresponding authors