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PolyU Scholars Hub

張國權博士

講師

BSc (HKBU), MPhil (CUHK), PhD (UCL)

簡歷

張博士在香港浸會大學取得應用生物學理學學士學位,其後香港中文大學獲得基礎醫學哲學碩士學位,在修讀碩士課程期間,對癌症病理學進行了深入研究。張博士於英國倫敦大學學院取得神經科學哲學博士學位後,在澳洲悉尼Victor Chang心臟研究中心進行了第一個博士後研究工作,內容為骨骼肌幹細胞的再生機制。在加入香港理工大學之前,他曾在香港中文大學擔任博士後研究員,內容主要為神經系統以及肌肉細胞再生及發展。

張博士的研究範疇為細胞在不同分化階段和成熟時期的動態表達方式,組織損傷的病理生理學以及組織再生過程中的機制。他同時也在進行通過控制基因的表達方式了解基因功能的研究。目前,他正與其他科研人員緊密合作,進行基礎科學研究。

學歷

  • Bachelor of Science in Applied Biology, Hong Kong Baptist University
  • Master of Philosophy, The Chinese University of Hong Kong
  • Doctor of Philosophy, University College London (University College London)

研究興趣

  • 骨骼肌及肌衛星細胞生物學
  • 糖尿病併發症病理生理學及介入
  • 組織損傷及再生機制

研究成果

  • Fung TK*, Cheung KK*, Wang X, Lau BWM, Ngai SPC. (2024) Transcriptomic Profiling Reveals Differences in Slow Twitch and Fast Twitch Muscles of a Cigarette Smoke-Exposed Rat Model. J Cachexia Sarcopenia Muscle. https://doi.org/10.1002/jcsm.13633
  • Lui K, Cheung KK, Ng WW, Wang Y, Au DWH, Cho WC. (2024) Genetic Mutations and Advances in Immunotherapy for Lung Cancer Treatment. Int J Mol Sci. 25(22), 11954. https://doi.org/10.3390/ijms252211954
  • Tam SY, Chung SF, Kim CF, To JC, So PK, Cheung KK, Chung WH, Wong KY, Leung TYC. (2023) Development of a bioengineered Erwinia chrysanthemi asparaginase to enhance its anti-solid tumor potential for treating gastric cancer. Int J Biol Macromol. 253(Pt 5):127742. https://doi.org/ 10.1016/j.ijbiomac.2023.127742
  • Lui K, Huang Y, Sheikh S, Cheung KK, Tam WY, Sun KT, Cheng KM, Ng WWM, Loh AWK. (2023) The oncogenic potential of Rab-like protein 1A (RBEL1A) GTPase: a mini review. J Cancer 14(17):3214-26. https://doi.org/10.7150/jca.84267
  • Zhou SJ, Cheing GLY#, Cheung AKK#. (2022) Role of exosomes, exosomal microRNA, in muscle-kidney crosstalk in chronic kidney disease. Front Cell Dev Biol 10:951837. https://doi.org/10.3389/fcell.2022.951837
  • He AWJ, Ngai SPC#, Cheung KK#, Lau BWM#, Sánchez-Vidaña DI, Pang MYC. (2022) Impacts of cigarette smoke (CS) on muscle derangement in rodents – a systematic review. Toxics 10:262. https://doi.org/10.3390/toxics10050262
  • Chen H, Siu SWI, Wong CTT, Qiu J, Cheung AKK#; Lee S#. (2022) Anti-epileptic Kunitz-like peptides discovered in the branching coral Acropora digitifera through transcriptomic analysis". Arch Toxicol 96(9):2589-2608. https://doi.org/10.1007/s00204-022-03311-4
  • Wang X; Liao Q, Chen H, Gong G, Siu SWI, Chen Q, Kam HT, Ung COL, Cheung KK, Rádis‑Baptista G, Wong CTT and Lee SMY. (2021) Toxic peptide from Palythoa caribaeorum acting on the TRPV1 channel prevents pentylenetetrazol-induced epilepsy in zebrafish larvae. Front Pharmacol 12:763089. https://doi.org/10.3389/fphar.2021.763089
  • Kannan P, Cheung KK, Lau BWM, Li L, Chen H and Sun F. (2021) A mixed-methods study to evaluate the effectiveness and cost-effectiveness of aerobic exercise for primary dysmenorrhea: A study protocol. PLoS One https://doi.org/10.1371/journal.pone.0256263
  • Yu KKK, Cheing GLY, Cheung C, Kranz GS, Cheung AKK. (2021) Gray matter abnormalities in type 1 and type 2 diabetes: a dual disorder ALE quantification. Front Neurosci 15:638861. https://doi.org/10.3389/fnins.2021.638861.
  • Chen H, Luo C, Ai G, Wang Y, Li C, Tan L, Lee SMY, Cheung AKK, Su Z, Xie J*, Wu X* and Zeng H*. (2021) A comparative investigation of the interaction and pharmacokinetics of hemoglobin with berberine and its oxymetabolite. J Pharm Biomed Anal 199:114032. https://doi.org/10.1016/j.jpba.2021.114032
  • Choi HMC, Cheung AKK, Ng MCH, Zheng YP, Jam YK, Cheing GLY. (2021) Indentation stiffness measurement by an optical coherence tomography-based air-jet indentation system can reflect type I collagen abundance and organisation in diabetic wounds. Front Bioeng Biotechnol 9:648453. https://doi.org/10.3389/fbioe.2021.648453
  • Tam WY, Wang X, Cheng ASK, Cheung KK#. (2021) In search of molecular markers for cerebellar neurons. Int J Mol Sci 22:1850. https://doi.org/10.3390/ijms22041850
  • Leung JWH, Cheung KK, Ngai SPC, Tsang HWH and Lau BWM. (2020) Protective effects of melatonin on neurogenesis impairment in neurological disorders and its relevant molecular mechanisms. Int J Mol Sci 21:5645. https://doi.org/10.3390/ijms21165645
  • Tam WY and Cheung KK#. (2020) Phenotypic characteristics of commonly used inbred mouse strains. J Mol Med 98:1215-1234. https://doi.org/10.1007/s00109-020-01953-4
  • Zhang EW, Li-Tsang CWP, Li TMH, Huang L and Cheung KK. (2020) Smart Scar Care Pad (SSCP) – an innovated silicone-based insert that improved severe hypertrophic scar by integrating optimal pressure and occlusion effects. Adv Wound Care 9(10):564-575. https://doi.org/10.1089/wound.2019.1016
  • Cheung KK*, Fung TKH*, Mak JCW, Cheung SY, He WJ, Leung JWH, Lau BWM and Ngai SPC. (2020) The acute effects of cigarette-smoke exposure on muscle fiber type dynamics in rats. PLoS One 15(5):e0233523. https://doi.org/10.1371/journal.pone.0233523
  • Choi HMC, Cheung AKK, Ng GYF and Cheing GLY. (2018) Effects of pulsed electromagnetic field (PEMF) on the tensile biomechanical properties of diabetic wounds at different phases of healing. PLoS One 13(11):e0208475. https://doi.org/10.1371/journal.pone.0208475
  • Sun KT, Cheung KK, Au SWN, Yeung SS and Yeung EW. (2018) Overexpression of mechano-growth factor modulates inflammatory cytokine expression and macrophage resolution in skeletal muscle injury. Front Physiol 9:999 https://doi.org/10.3389/fphys.2018.00999
  • Yeung EW, Cheung KK, Sun KT. (2017) Biological Role of TRPC1 in myogenesis, regeneration and disease. In ‘The Plasticity of Skeletal Muscle—From Molecular Mechanism to Clinical Applications” Ed by Sakuma K. Springer Singapore. https://doi.org/ 10.1007/978-981-10-3292-9_10
  • Yang BR*, Cheung KK*, Zhou X, Xie RF, Chen PP, Wu S, Zhou ZY, Tang JY, Hoi PM, Wang YH and Lee SMY. (2016) Amelioration of acute myocardial infarction by saponins from flower buds of Panax notoginseng via pro-angiogenesis and anti-apoptosis. J Ethnopharmacol 181:50-8. https://doi.org/10.1016/j.jep.2016.01.022 (*co-first authors)
  • Xia L, Cheung KK, Yeung SS and Yeung EW. (2016) The involvement of TRPC1 in skeletal muscle regrowth after unloading-induced atrophy. J Physiol (London) 594:3111-26. https://doi.org/10.1113/JP271705

*Co-first author; # corresponding authors

 

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