Dr Mu Quanhua

Academic Staff

Assistant Professor

Research Overview

Our research focuses on developing and applying computational methods to reveal key factors regulating cancer progression and drug response, aiming for precise diagnosis and treatment of cancer patients.

Academic and Professional Experience

Member, Bioinformatics Society of Hong Kong SAR (BISHK)
Trainee Member, Society of Neuro-Oncology (SNO)

Research Interests

Achievements

China Top 10 Research Advances in Glioma Research of the Year, Chinese Glioma Collaborative Research Group, 2020
HKMHDIA Research Award, Hong Kong Medical Device Industry Association, 2019
Research Travel Grant, Hong Kong University of Science and Technology, 2019
China Top 10 Research Advances in Life Sciences of the Year, Chinese Union of Life Science Societies, 2018
School of Engineering Top Research Postgraduate Award, Hong Kong University of Science and Technology, 2018

1. Quanhua Mu*, Ruichao Chai*, Hanjie Liu, Yingxi Yang, Zheng Zhao, Ming Hong Lui, Zhaoshi Bao, Dong Song, Biaobin Jiang, Jason K. Sa, Hee Jin Cho, Yuzhou Chang, Kaitlin HY Chan, Danson Shek Chun Loi, Sindy Sing Ting Tam, Aden Ka Yin Chan, Wai Sai Poon, Ho Keung Ng, Danny Chan, Angela R. Wu, Antonio Iavarone, Do-Hyun Nam, Tao Jiang, Jiguang Wang. Identifying predictors of glioma evolution from longitudinal sequencing. Science Translational Medicine, 2023; 15(716):eadh4181.
2. Huimin Hu*, Quanhua Mu*, Zhaoshi Bao*, Yiyun Chen*, Yanwei Liu*, Jing Chen, Kuanyu Wang, Zheng Wang, Yoonhee Nam, Biaobin Jiang, Jason K Sa, Hee-Jin Cho, Nam-Gu Her, Chuanbao Zhang, Zheng Zhao, Ying Zhang, Fan Zeng, Fan Wu, Xun Kang, Yuqing Liu, Zenghui Qian, Zhiliang Wang, Ruoyu Huang, Qiangwei Wang, Wei Zhang, Xiaoguang Qiu, Wenbin Li, Do-Hyun Nam, Xiaolong Fan, Jiguang Wang, Tao Jiang. Mutational landscape of secondary glioblastoma guides MET-targeted trial in brain tumor. Cell, 2018; 175(6): 1665-1678.
3. Barbara Oldrini*, Nuria Vaquero-Siguero*, Quanhua Mu*, Paula Kroon, Ying Zhang, Marcos Galan-Ganga, Zhaoshi Bao, Zheng Wang, Hanjie Liu, Jason K Sa, Junfei Zhao, Hoon Kim, Sandra Rodriguez-Perales, Do-Hyun Nam, Roel GW Verhaak, Raul Rabadan, Tao Jiang, Jiguang Wang, Massimo Squatrito. MGMT genomic rearrangements contribute to chemotherapy resistance in gliomas. Nature Communications, 2020; 11:3883.
4. Yiming Wan*, Quanhua Mu*, Rafał Krzysztoń*, Joseph Cohen, Damiano Coraci, Christopher Helenek, Christopher Tompkins, Annie Lin, Kevin Farquhar, Erin Cross, Jiguang Wang, Gábor Balázsi. Adaptive DNA amplification of synthetic gene circuit opens a way to overcome cancer chemoresistance. Proceedings of the National Academy of Sciences of the United States of America, 2023; 120 (49): e2303114120.
5. Quanhua Mu*, Yiyun Chen*, Jiguang Wang. Deciphering brain complexity using single-cell sequencing. Genomics, Proteomics & Bioinformatics, 2019; 17:344-366
6. Quanhua Mu, Jiguang Wang. CNAPE: A Machine Learning Method for Copy Number Alteration Prediction from Gene Expression. IEEE/ACM Transactions on Computational Biology and Bioinformatics, 2019, 18(1): 306-311.
7. Biaobin Jiang, Quanhua Mu, Fufang Qiu, Xuefeng Li, Weiqi Xu, Jun Yu, Weilun Fu, Yong Cao, Jiguang Wang. Machine learning of genomic features in organotropic metastases stratifies progression risk of primary tumors. Nature Communications, 2021; 12:1-15.
8. Lei Yu, Xinlei Wang, Quanhua Mu, Sindy Tam, Aden Chan, Wai Sang Poon, Ho Keung Ng, Danny T.M. Chan, Jiguang Wang, Angela R Wu. scONE-seq: A one-tube single-cell multi-omics method enables simultaneous dissection of genotype and phenotype heterogeneity from frozen tumor samples. Science Advances, 2023, 9(1): eabp8901.
9. Xiaolong Wang*, Zeyou Chen*, Quanhua Mu*, Xinyan Wu, Jingjing Zhang, Daqing Mao, Yi Luo, Pedro JJ Alvarez. Ionic liquid enriches the antibiotic resistome, especially efflux pump genes, before significantly affecting microbial community structure. Environmental Science & Technology, 2020; 54(7): 4305-15.
10. Quanhua Mu, Jin Li, Yingxue Sun, Daqing Mao, Qing Wang, Yi Luo. Occurrence of sulfonamide-, tetracycline-, plasmid-mediated quinolone-and macrolide-resistance genes in livestock feedlots in Northern China. Environmental Science and Pollution Research, 2015; 22: 6932-40.