Dr XIE Chen
Research Assistant Professor
- Y824-02
- +852 3400 2632
- chen-polyu.xie@polyu.edu.hk
Research Overview
My research is dedicated to advancing innovative strategies in medical imaging and therapeutics, utilizing AI to enhance discovery and application. By applying various types of radiation and exploring the unique functionalities of small molecules, I aim to develop safer, more efficient diagnostic and treatment options that enhance public health and patient outcomes.
Research Interests
Achievements
- Xie C., Li X., Zhang L., Chau H.-F., Thor W., Tam W. S., Woolley B., Jiang M., Ng C.-F., Botta M., Zhang T., Long N. J., Law G.-L., Wong K-L., Bimetallic Porphyrin PET Radiotracers for Low-Dose MRI Contrast Enhancement. Chemical Engineering Journal, 2024, 495, 153390.
- Cheung T.-L., Tam L. K. B., Tam W.-S., Zhang L., Kai H.-Y., Thor W, Wu Y., Lam P.-L., Yeung Y.-H., Xie C., Chau H.-F., Lo W.-S., Zhang T., Wong K.-L., Facile Peptide Macrocyclization and Multifunctionalization via Cyclen Installation. Small Methods, 2024, 2400006.
- Xie C., Wu Y., Chau H.-F., Zhang T., Wong C. T., Yeung Y.-H., Lam P.-L., Bünzli J. C. G., Charbonnière L. J., Law G.-L., Wong K.-L., Multi-modal Visualization of Bioorthogonal Systems by Off-On Luminescence and Enhanced Magnetic Resonance Imaging. Advanced Optical Materials, 2023, 11, 2203057.
- Li X., Xie C., Zha S., Tam W. S., Jiang M., Wong K.-L., Biocompatible Porphyrin-Peptide Conjugates as Theranostic Agents Targeting the Epstein–Barr Virus. ChemPlusChem, 2022, 87, e202200184.
- Chan W.-L., Xie C., Lo W.-S., Bünzli J.-C. G., Wong W.-K., Wong K.-L., Lanthanide–tetrapyrrole complexes: synthesis, redox chemistry, photophysical properties, and photonic applications. Chemical Society Reviews, 2021, 50, 12189-12257.
- Chau, H.-F., Xie, C., Wong, K.-L., Development of "Smart" photodynamic theranostics agents (Book Chapter). Comprehensive Coordination Chemistry III, 2021, 9, 771-786.
- Xie C, Chau H.-F., Zhang J. X., Tong S., Jiang L.J., Fok W.-Y.,Lung H.-L., Zha S., Zou R., Jiao J., Ng C.-F., Ma P., Zhang J., Lin J., Shiu K. K.,Bünzli J.-C. G.,Wong W.-K., Long N. J.,Law G.-L., Wong K.-L., Bladder Cancer Photodynamic Therapeutic Agent with Off‐On Magnetic Resonance Imaging Enhancement. Advanced Therapeutics, 2019, 2, 1900068.
- Zhang J.X., Chan W.-L., Xie C., Zhou Y., Chau H.-F., Maity P., Harrison G.T., Amassian A., Mohammed O.F., Tanner P.A., Wong W.-K., Wong K.-L., Impressive near-infrared brightness and singlet oxygen generation from strategic lanthanide–porphyrin double-decker complexes in aqueous solution. Light: Science & Applications, 2019, 8:46.
- Jiang L.J., Xie C., Lung H.L., Lo K.W., Law G.L., Mak N.K., Wong K.L., EBNA1-targeted inhibitors: Novel approaches for the treatment of Epstein-Barr virus-associated cancers. Theranostics, 2018, 8(19):5307-5319.
- Yao S., Zheng Y., Jiang L.J., Xie C., Wu F., Huang C., Zhang X., Wong K.L., Li Z., Wang K., Methylene violet 3RAX-conjugated porphyrin for photodynamic therapy: Synthesis, DNA photocleavage, and cell study. RSC Advances, 2018, 8(8), 4472-4477.
