- Y722
- +852 3400 8730
- xiulian.yu@polyu.edu.hk
ORCID ID
SCOPUS IDResearch Overview
My research focuses on studying the molecular mechanism of a series of pore-forming proteins involved in host defense and pathogens invasion by using the state-of-art structural biology approaches such as cryoEM, cryoET and subtomogram averaging.
Education and Academic Qualifications
- Master of Science, Nankai University
- Doctor of Science, European Molecular Biology Laboratory
Research Interests
Achievements
- Yu X, Ni T, Munson G, Zhang P & Gilbert RJC. Cryo-EM structures of perforin‐2 in isolation and assembled on a membrane suggest a mechanism for pore formation. EMBO J (2022) e111857.
- Jiao F, Dehez F, Ni T, Yu X, Dittman J, Gilbert RJC, Chipot C, Scheuring S. Perforin-2 clockwise hand-over-hand pre-pore to pore transition mechanism. Nat Commun 13, 5039 (2022).
- Ni T, Sun Y, Burn W, Al-Hazeem MMJ, Zhu Y, Yu X, Liu LN, Zhang P. Structure and assembly of cargo Rubisco in two native α-carboxysomes. Nat Commun. 2022 Jul 25;13(1):4299. PMID: 35879301; PMCID: PMC9314367.
- Williams SI*, Yu X* (co-first), Ni T, Gilbert RJC, Stansfeld PJ. Structural, Functional and Computational Studies of Membrane Recognition by Plasmodium Perforin-Like Proteins 1 and 2. J Mol Biol. 2022 Jul 15;434(13):167642. Epub 2022 May 19. PMID: 35598848.
- Caggiano MP, Yu X, Ohno C, Sappl P, Heisler MG. Live Imaging of Arabidopsis Leaf and Vegetative Meristem Development. Methods Mol Biol. 2021;2200:295-302. doi: 10.1007/978-1-0716-0880-7_13. PMID: 33175383.
- Ram H, Sahadevan S, Gale N, Caggiano MP, Yu X, Ohno C, Heisler MG. An integrated analysis of cell-type specific gene expression reveals genes regulated by REVOLUTA and KANADI1 in the Arabidopsis shoot apical meristem. PLoS Genet. 2020 Apr 15;16(4):e1008661.
- Ni T*, Jiao F*, Yu X* (co-first), Aden S, Ginger L, Williams SI, Bai F, Pražák V, Karia D, Stansfeld P, Zhang P, Munson G, Anderluh G, Scheuring S, Gilbert RJC. Structure and mechanism of bactericidal mammalian perforin-2, an ancient agent of innate immunity. Sci Adv. 2020 Jan 29;6(5):eaax8286.
- Caggiano MP*, Yu X* (co-first), Bhatia N*, Larsson A, Ram H, Ohno CK, Sappl P, Meyerowitz EM, Jönsson H, Heisler MG. Cell type boundaries organize plant development. Elife. 2017 Sep 12;6:e27421.
- Xiong J, Cui X, Yuan X, Yu X, Sun J, Gong Q. The Hippo/STE20 homolog SIK1 interacts with MOB1 to regulate cell proliferation and cell expansion in Arabidopsis. J Exp Bot. 2016 Mar; 67(5):1461-75.
