- Y846
- +852 3400 8711
- q.zhao@polyu.edu.hk
- Lab Webpage
ORCID ID
SCOPUS IDEducation and Academic Qualifications
- Bachelor of Engineering, Xi'an Jiaotong University
- Doctor of Philosophy, The University of Hong Kong
Research Overview
(1) To study the mechanisms and to facilitate the development of innovative anticancer molecules.
(2) To develop novel chemical proteomic approaches for studying fundamental biology.
(3) To investigate novel functional peptides, including cytosolic peptides and immuopeptides, particularly those encoded by small open reading frames.
Academic and Professional Experience
- Editorial board member, Molecular & Cellular Proteomics
- Editorial board member, Chinese Chemical Letters
- Council member, The Human Proteome Organization (HUPO)
- Member, American Society for Mass Spectrometry
Research Interests
Achievements
- 2024 “Rising Stars in Proteomics and Metabolomics” by the Journal of Proteome Research
- 2021 “Emerging Investigators in Mass Spectrometry” by the Journal of the American Society for Mass Spectrometry
- 2015 Gordon Conference Travel Award
- 2011 Utrecht University Short-stay Fellowship
- Editorial Board Member of “Molecular & Cellular Proteomics” and “Chinese Chemical Letters”
- Council Member of The Human Proteome Organization (HUPO)
- Permanent Member of Chinese American Society for Mass Spectrometry
- Wang CD, Liu ZR, Zeng YL, Zhou LJ, Long Q, Hassan I UI, Zhang YL, Qi XF, Cai DQ, Mao BY, Lu G, Sun JM, Yao YG, Deng Y, Zhao Q, Feng B, Zhou Q, Chan WY, Zhao H*. ZSWIM4 regulates embryonic patterning and BMP signaling by promoting nuclear Smad1 degradation. EMBO Reports. 2024, 1-26.
- Leeman-Neill RJ, Song D, Bizarro J, Wacheul L, Rothschild G, Singh S, Yang Y, Sarode AY, Gollapalli K, Wu LJ, Zhang WW, Chen YY, Lauring MC, Whisenant DE, Bhavsar S, Lim JH, Swerdlow SH, Bhagat G, Zhao Q, Berchowitz LE, Lafontaine DLJ, Wang JG*, Basu U*. Noncoding mutations cause super-enhancer retargeting resulting in protein synthesis dysregulation during B cell lymphoma progression. Nature Genetics. 2023, 55, 2160-2174.
- Leung CON, Yang Y, Leung RW, So KK, Guo HJ, Lei MM, Muliawan GK, Gao Y, Yu QQ, Yun JP, Ma S, Zhao Q*, Lee TK*. Broad-spectrum kinome profiling identifies CDK6 upregulation as a driver of lenvatinib resistance in hepatocellular carcinoma. Nature Communications. 2023, 14, 6699.
- Li SR, Zhu CJ, Zhao Q, Zhang ZM*, Sun PH*, Li ZQ*. Ynamide Coupling Reagent for the Chemical Cross-Linking of Proteins in Live Cells. ACS Chemical Biology. 2023, 18(6):1405-1415.
- Li J#, Dong JQ#, Wang WT#, Yu DQ#, Fan XY, Hui YC, Lee SK, Lam WH, Alary N, Yang Y, Zhao Q, Chen CL*, Tye BK*, Dang SY*, Zhai YL*. The human pre-replication complex is an open complex. Cell. 2023, 186(1):98-111.
- Yang Y#, Wang HW#, Zhang YL, Chen L, Chen GL, Bao ZS, Yang Y, Xie Z, Zhao Q*. An Optimized Proteomics Approach Reveals Novel Alternative Proteins in Mouse Liver Development. Molecular & Cellular Proteomics. 2023, 22(1):100480.
- Guo HJ#, Yang Y#, Zhang Q#, Deng JR, Yang Y, Li SQ, So PK, Lam TC, Wong MK, Zhao Q*. Integrated Mass Spectrometry Reveals Celastrol as a Novel Catechol-O-methyltransferase Inhibitor. ACS Chemical Biology. 2022, 17(8):2003-2009.
- Luan YZ, Tang N, Yang JQ, Liu ST, Cheng CC, Wang Y, Chen CY, Guo YN, Wang HW, Zhao WX, Zhao Q, Li W, Xiang MQ, Ju R*, Xie Z*. Deficiency of ribosomal proteins reshapes the transcriptional and translational landscape in human cells. Nucleic Acids Research. 2022, 50(12):6601-6617.
- Shen CZ#, Zhang DT#, Xu F#, Yang Y#, Tan Y, Zhao Q*, Li L, Ding K, Li ZQ*. Two-photon fluorescent turn-on probes for highly efficient detection and profiling of thiols in live cells and tissues. Biological Chemistry. 2021, 403(4):445-451.
- Chen L, Yang Y, Zhang YL, Li KC, Cai HM, Wang HW, Zhao Q*. The Small Open Reading Frame-Encoded Peptides: Advances in Methodologies and Functional Studies. ChemBioChem. 2021, 23(8):e202100534.
- Chen L, Zhang YL, Yang Y, Yang Y, Li HH, Dong X, Wang HW, Xie Z, Zhao Q*. An integrated approach for discovering non-canonical MHC-I peptides encoded by small open reading frames. Journal of the American Society for Mass Spectrometry. 2021, 32(9):2346-2357.
- Wang HW#, Wang Y#, Yang JQ#, Zhao Q#, Tang N, Chen CY, Li HH, Cheng CC, Xie MZ, Yang Y, Xie Z*. Tissue- and stage-specific landscape of the mouse translatome. Nucleic Acids Research. 2021, 49(11):6165-6180.
- Leung HW, Leung CON, Lau EY, Chung KPS, Mok EH, Lei MML, Leung RWH, Tong M, Keng V, Ma C, Zhao Q, Ng IOL, Ma S*, Lee KW*. EPHB2 activates β-catenin to enhance cancer stem cell properties and drive sorafenib resistance in hepatocellular carcinoma. Cancer Research. 2021, 81(12):3229-3240.
- Sze YH, Zhao Q, Cheung JKW, Li KK, Tse DYY, To CH, Lam TC*. High-pH reversed-phase fractionated neural retina proteome of normal growing C57BL/6 mouse. Scientific Data. 2021, 8(27).
- Shao XJ, Ji FF, Wang YW, Zhu L, Zhang Z, Du XB, Chung ACK, Hong YJ, Zhao Q*, Cai ZW*. Integrative Chemical Proteomics-Metabolomics Approach Reveals Acaca/Acacb as Direct Molecular Targets of PFOA. Analytical Chemistry. 2018, 90(18):11092-11098.
- Terenzio M, Koley S, Samra N, Rishal I, Zhao Q, Sahoo PK, Urisman A, Marvaldi L, Oses-Prieto JA, Forester C, Gomes C, Kalinski AL, Di Pizio A, Doron-Mandel E, Perry RBT, Koppel I, Twiss JL, Burlingame AL, Fainzilber M*. Locally translated mTOR controls axonal local translation in nerve injury. Science. 2018, 359(6382):1416-1421.
- Forester CM#, Zhao Q#, Phillips NJ, Urisman A, Chalkley RJ, Oses-Prieto JA, Zhang L, Ruggero D*, Burlingame AL*. Revealing nascent proteomics in signaling pathways and cell differentiation. Proceedings of the National Academy of Sciences U S A. 2018, 115(10):2353-2358.
- Zhao Q#, Ouyang XH#, Wan XB, Gajiwala KS, Kath JC, Jones LH, Burlingame AL, Taunton J*. Broad-Spectrum Kinase Profiling in Live Cells with Lysine-Targeted Sulfonyl Fluoride Probes. Journal of the American Chemical Society. 2017, 139(2):680-685.
- Xiang L, Wei JT, Tian XY, Wang B, Chan W, Li SF, Tang Z, Zhang HS, Cheang WS, Zhao Q, Zhao HZ, Yang ZY, Hong YJ, Huang Y*, Cai ZW*. Comprehensive Analysis of Acylcarnitine Species in db/db Mouse Using a Novel Method of High-Resolution Parallel Reaction Monitoring Reveals Widespread Metabolic Dysfunction Induced by Diabetes. Analytical Chemistry. 2017, 89(19):10368-10375.
- Zhao Q, Ding Y, Deng ZS, Lee OY, Gao P, Chen P, Rose RJ, Zhao H, Zhang ZH, Tao XP, Heck AJR, Kao R, Yang D*. Natural products triptolide, celastrol, and withaferin A inhibit the chaperone activity of peroxiredoxin I. Chemical Science. 2015, 6(7):4124-4130.
- Bao X#, Zhao Q#, Yang TP, Fung YME*, Li XD*. A Chemical Probe for Lysine Malonylation. Angewandte Chemie - International Edition. 2013, 52(18):4883-4886.
