ORCID ID
SCOPUS IDEducation and Academic Qualifications
- Bachelor of Medicine, Qingdao University
- Master of Science, Qingdao University
- Doctor of Philosophy, The Hong Kong Polytechnic University
Research Overview
The primary focus of Dr Zhou’s research is to develop Chinese Medicine and Regenerative Medicine-based therapeutic strategies against aging-related eye disorders, as well as to determine the mechanisms involved in mediating their beneficial activities.
Research Interests
Achievements
- Zhou L, Wong KY, Poon CC, Yu W, Xiao H, Chan CO, Mok DK, Wong MS. Water extract of Rhizoma Drynaria selectively exerts estrogenic activities in ovariectomized rats and estrogen receptor-positive cells. Front Endocrinol 2022;13:817146. doi.org/10.3389/fendo.2022.817146.
- Guan Y, Wang R, Zou H, Yu W, Liang Z, Li L, Chen L, Zhou L#, Chen Z. Astrocytes constitute the major TNF-α-producing cell population in the infarct cortex in dMCAO rats receiving intravenous MSC infusion. Biomed Pharmacother. 2021;142:111971. doi: 10.1016/j.biopha.2021.111971. (#Co-corresponding author)
- Wong KY*, Zhou L*, Yu W, Poon CC, Xiao H, Chan CO, Mok DK, Wong MS. Water extract of Er-xian decoction selectively exerts estrogenic activities and interacts with SERMs in estrogen-sensitive tissues. J Ethnopharmacol. 2021;275:114096. doi: 10.1016/j.jep.2021.114096. (*Co-first author)
- Zhou L, Wong KY, Yu W, Poon CC, Xiao H, Chan CO, Mok DK, Zhang Y, Wong MS. Selective estrogen receptor modulator-like activities of Herba epimedii extract and its interactions with tamoxifen and raloxifene in bone cells and tissues. Front Pharmacol. 2021;11:571598. doi: 10.3389/fphar.2020.571598.
- Zhou L, Poon CC, Wong KY, Cao S, Dong X, Zhang Y, Wong MS. Icariin ameliorates estrogen-deficiency induced bone loss by enhancing IGF-I signaling via its crosstalk with non-genomic ERα signaling. Phytomedicine. 2021;82:153413. doi: 10.1016/j.phymed.2020.153413.
- Zhou L, Wong KY, Cao S, Poon CC, Yu W, Dong X, Tsim KW, Wong MS. A standardized extract of Danggui Buxue Tang decoction selectively exerts estrogenic activities distinctly from tamoxifen. Phytother Res. 2021;35:1456-1467. doi: 10.1002/ptr.6909.
- Gao QG*, Zhou LP*, Lee VH, Chan HY, Man CW*, Wong MS*. Ginsenoside Rg1 activates ligand-independent estrogenic effects via rapid estrogen receptor signaling pathway. J Ginseng Res. 2019;43:527-538. doi: 10.1016/j.jgr.2018.03.004. (*Co-first author)
- Zhou L, Poon CC, Wong KY, Cao S, Yu W, Dong X, Lee WY, Zhang Y, Wong MS. Prenylflavonoid Icariin induces estrogen response element-independent estrogenic responses in a tissue-selective manner. J Endocr Soc. 2019;4(2):bvz025. doi: 10.1210/jendso/bvz025.
- Zhou LP, Wong KY, Yeung HT, Dong XL, Xiao HH, Gong AG, Tsim KW, Wong MS. Bone protective effects of Danggui Buxue Tang alone and in combination with tamoxifen or raloxifene in vivo and in vitro. Front Pharmacol. 2018;9:779. doi: 10.3389/fphar.2018.00779.
