Prof. Xing Bengang

Academic Staff

Chair Professor of Chemical Biology

Research Overview

My research interests are highly interdisciplinary at the interfaces of chemical biology, molecular probe & imaging, biomedical-labeling as well as molecular therapy and nano-theranostics engineering. Specific aims of ours are to develop and identify the "smart" small molecules, natural products, bioactive peptides and/or their analogues to solve biological and medicinal problems. We are also interested in development of new functional molecular tools and nanomaterial hybrids as chemical biology strategies for biolabeling, imaging & biosensing, drug/gene delivery or potential biomedical theranostics engineering.

Professional Qualifications

Singapore representative of Asian Chemical Biology Initiative (ACBI), JSPS, Japan
International Advisory Board (IAB) and Chair of IUPAC/13 International Symposium on Bio-organic Chemistry (ISBOC 13) in 2023.
Advisory editorial board member for multiple academic journals including Journal of Controlled Release, Bioconjugate Chemistry (ACS), NPG Asia Materials, NanoTheranostics, iRADIOLOGY, J. Nanobiotechnology etc.
Guest editor for Advanced Drug Delivery Reviews (ADDR) in 2022

Research Interests

Achievements

“Enzyme in Synergy: Bacteria Specific Molecular Probe for Locoregional Imaging Urinary Tract Infection in vivo.” E. Yan, G. Kwek, X. An, C. Sun, S. Liu, S. Q. Ng, S. Lingesh,L. Jiang, G. Liu*, B. G. Xing*, Angew. Chem. Intl. Ed. 2024, 64, e202406843. 'VIP" paper,
“A Nitroreductase-activatable Metabolic Reporter for Covalent Labeling of Pathological Hopoxic Cells in Tumorigenesis.” Z. Wang*, J. Lau, S. Liu, Z. Gong, X. Liu, B. G. Xing*, Angew. Chem. Intl. Ed. 2024, 64, e202411636.
“Nanoparticles-mediated Ion Channels Manipulation: From Their Membrane Interactions to Bioapplications.” Q. Huang, W. Zhu, X. Gao, X. Liu, Z. Zhang*, B. G. Xing*, Adv Drug Delivery Rev., as Theme Issue & Guest Editor, Article 114763, 2023.; Preface Article 114991, 2023.
“Hypoxia Deactivates Epigenetic Feedbacks via Enzyme-derived Clickling Proteolysis Targeting Chimeras”, T. Do, J. Lau, C. Sun, S. Liu, K. Kha, S. Lim, Y. Oon, Y. Kwan, J. Ma, Y. Mu, X. Liu, T. Carney, X. Wang*, B. G. Xing*, Sci. Adv., 2022, 8 (50), abq2216.
“Cyanine-Dyad Molecular Probe for Simultaneous Profiling of Multiple Radical Species Evolution in Bacterial Infection". Z. Wang, C. D. Thang, W.Zhong, J. W. Lau; G. Kwek; M. B. Chan-Park, B. G. Xing*, Angew. Chem. Intl. Ed, 2021, 60, 16900, “VIP” paper.
“Multispectral Optoacoustic Imaging of Dynamic Redox Correlation and Pathophysiological Progression Utilizing Upconversion Nanoprobes.” X. Ai, Z. Wang, H. Cheong, Y. Wang, R. Zhang, J. Lin, Y. Zheng, Y. Gao*, B. G. Xing*. Nat. Commun. 2019, 10, 1087, Featured by "X-Mol", "Nature Communications Editors' Highlights", “University Frontier Research Highlight” in NTU.
“Remote Regulation of Membrane Channel Activity by Site-specific Localization of Lanthanide doped Upconversion Nanocrystals.” X. Ai, L. Lyu, Y. Zhang, Y. Tang, J. Mu, F. Liu, Y. Zhou, Z. Zuo, G. Liu*, B. G. Xing*, Angew. Chem. Intl. Ed, 2017, 56, 3031.
“In vivo Covalent Cross-linking of Photon-converted Rare-earth Nanostructures for Tumor Localization and Theranostics.” X. Z. Ai, C. Ho, J. Aw, A. Attia, J. Mu, Y. Wang, X. Wang, Y. wang, X. Liu, H. Chen, M. Gao, X. Chen, E. K. Yeow, G. Liu*, M. Olivo*, B. G. Xing*. Nature Communications, 2016, 7, 10432
“NIR Light Mediated Photoactivation of a Platinum Antitumor Prodrug and Simultaneous Cellular Apoptosis Imaging Via Upconversion Nanoparticles.” Y. Min, J. Li, F. Liu, K. Yeow*, B. G. Xing*. Angew. Chem. Intl. Ed, 2014, 53, 1012.
“Real-Time Visualization of Cell-Surface Proteolytic Enzyme Functions using a Small-Molecule FRET Probe” J. Mu, F. Liu*, M. Rajab, M. Shi, S. Li, C. Goh, L. Lu, Q. Xu, B. Liu, L. Ng, B. G. Xing*, Angew Chem. Intl. Ed.,2014, 53, 14357.

B. G. Xing, E. Yan, G. Kwek, Enzymes In Synergy: Bacterial Proteases Mediated In Vivo Real-Time Imaging of Localized Urinary Tract Infection, 2023-329-02-PCT/PRV, 10202303589T SG, 2023
B. G. Xing, L. Qiao, W. Lang. Intelligent NIR II Photothermal And Colorimetric Sensing Technology, PCT/SG2023/050719, 2023
B. G. Xing, C. T. Do. Compounds For Use In The Treatment Of Cancer. PCT/SG2022/050282, WO/2022/235220, 2022.
B. G. Xing; X. Huang, T. Jiang, R. Liu, “Multifunctional Glycopeptide Antibiotic Derivatives for Fluorescent Imaging and Photoactive Antimicrobial Therapy. US9476087B2, 2016
B. G. Xing, C. T. Do. Enzyme Triggered Degradation of Tumour Circadian: A New And Unique Drug-Free Strategy For Specific Therapy. 2020, TD 2021-142.; 2021-142-01-SG PRV.
B. G. Xing, J. Aw, Q. Shao, Y. Yang, T. Jiang, C. Ang, Quinazolinone based fluorogenic probes, PCT US8697714B2, 2014.
T. Loh, B. Ata., B. G. Xing; TD/086/14; Allenamides As Orthogonal Handle for Selective Modification Of Cysteine in Peptides and Proteins. USA patent. A) US Application No: 15/303,670., European Patent No: 15780447.7, US10294205B2, 2019

2017 Fellow of the Royal Society of Chemistry (FRSC), UK
2018 Young Innovator Award in Nano-biotechnology, featured by Nano Research