- HJ507
- +852 3400 2798
- jingfang.jf.bian@polyu.edu.hk
ORCID ID
SCOPUS IDBiography
Dr Jennifer Bian obtained a first-class honours degree in Clinical Medicine from the School of Optometry and Ophthalmology of the Tianjin Medical University in 2009. From 2009 to 2012, she worked at the Tianjin Medical University Eye Hospital, gaining experience in Optometry and Ophthalmology. She later received a scholarship from PolyU to pursue postgraduate study, obtaining her PhD degree at the School of Optometry (SO) in 2021. Her PhD thesis mainly focused on Proteomics in a lens-induced myopia (LIM) guinea pig model. In addition to her PhD study, she also actively participated in various research projects associated with myopia, glaucoma, and tear biomarkers. She has actively participated in international conferences, at which she obtained three conference awards. She also actively serves as a member of The Hong Kong Society of Mass Spectrometry, and the Ophthalmic Testing Group of the Ophthalmology Professional Committee of the China Medical Equipment Association. Dr Bian worked as a Postdoctoral Fellow under a project supported by the Research Centre for SHARP Vision (RCSV) of PolyU Academy for Interdisciplinary Research (PAIR) before joining SO as a Research Assistant Professor in 2023.
Research Overview
Dr Bian’s main research interests are understanding the mechanism of myopia development and pharmacological interventions using an interdisciplinary approach. In her PhD study, she first developed and applied integrated next-generation proteomics to discover potential retinal biomarkers and related biochemical pathways in emmetropization in LIM guinea pigs. Over the same period, she also integrated proteomic and transcriptomic high-throughput approaches to provide multi-faceted insights into the interrelation of omics layers in myopia. Her more recent research has focused on the development of retinal cell-specific proteomics, single-cell transcriptomics, and Artificial intelligence (AI)-based analysis of multi-omics data. Dr Bian is also interested in the use of Traditional Chinese Medicine (TCM) for myopia control and intraocular fluid biomarkers in ocular diseases.
Education and Academic Qualifications
- Bachelor of Clinical Medicine (Ophthalmology and Optometry Track), Tianjin Medical University
- Doctor of Philosophy, The Hong Kong Polytechnic University
- Member, The Hong Kong Society of Mass Spectrometry
- Member of the Ophthalmic Testing Group of the Ophthalmology Professional Committee of China Medical Equipment Association
Professional Qualifications
- Senior Optometrist in the Chinese Mainland
Research Interests
Research Output
- Bian J, Sze YH, Tse DY, To CH, McFadden SA, Lam CS, Li KK, Lam TC. SWATH based quantitative proteomics reveals significant lipid metabolism in early myopic guinea pig retina. Int J Mol Sci. 2021;22(9):4721. doi: 10.3390/ijms22094721.
- Zhu Y*, Bian JF*, Lu DQ, To CH, Lam CS, Li KK, Yu FJ, Gong BT, Wang Q, Ji XW, Zhang HM, Nian H, Lam TC, Wei RH. Alteration of EIF2 signaling, glycolysis, and dopamine secretion in form-deprived myopia in response to 1% atropine treatment: Evidence from interactive iTRAQ-MS and SWATH-MS proteomics using a guinea pig model. Front Pharmacol. 2022;13:814814. doi: 10.3389/fphar.2022.814814. (*co-first authors)
- Ma JYW, Sze YH, Bian JF, Lam TC. Critical role of mass spectrometry proteomics in tear biomarker discovery for multifactorial ocular diseases (Review). Int J Mol Med. 2021 ;47(5):83. doi: 10.3892/ijmm.2021.4916.
- Shan SW, Tse DY, Zuo B, To CH, Liu Q, McFadden SA, Chun RK, Bian J, Li KK, Lam TC. Integrated SWATH-based and targeted-based proteomics provide insights into the retinal emmetropization process in guinea pig. J Proteomics. 2018 15;181:1-15. doi: 10.1016/j.jprot.2018.03.023
- Wu Y, Lam CS, Tse DY, To CH, Liu Q, McFadden SA, Chun RK, Li KK, Bian J, Lam C. Early quantitative profiling of differential retinal protein expression in lens-induced myopia in guinea pig using fluorescence difference two-dimensional gel electrophoresis. Mol Med Rep. 2018 ;17(4):5571-5580. doi: 10.3892/mmr.2018.8584.
- Cheung JK*, Bian J*, Sze YH, So YK, Chow WY, Woo C, Wong MT, Li KK, Lam TC. Human tear proteome dataset in response to daily wear of water gradient contact lens using SWATH-MS approach. Data Brief. 2021;36:107120. doi: 10.1016/j.dib.202 (*co-first authors)
