Chief Supervisor

Dr Thomas LAM

Project Title

Impact of bright light treatment on Avian myopic model – biometric and metabolomic changes

Synopsis

Myopia is the result of a mismatch between the optical power and the length of the eye, with the latter being too long. As in high myopia, there is an increased risk of ocular complications and visual impairment. Previous animal works and clinical studies strongly implicate light mediation in myopia development. There are many unresolved questions, including whether the same or different retinal (signaling) pathways underlie myopic growth, what retinal cells are involved, and what role it plays in regulating myopia related to lighting and wavelengths. The main purpose of this project is to experimentally examine the influence and molecular mechanism of light mediation on myopia in lens induced myopia (LIM) using next-generation proteomics coupled to cloud-based bioinformatics.