Chief Supervisor

Prof. Henry CHAN

Project Title

Synopsis

Refractive error is one of the most common eye disorders and a major cause of blindness worldwide. The prevalence of myopia and high myopia has increased dramatically in recent decades. In the effort to tackle the rapid progression of myopia and prevent the onset of high myopia, a range of strategies have been explored both pharmacologic and non-pharmacologic.

Both 0.05% atropine and Defocused Incorporated Multiple Segments (DIMS) have been demonstrated to have a significant protective effect on myopia progression. However, no previous studies have compared the effectiveness of treatment in children with fast and slow myopia progression for either. The retina is involved in the development of myopia. There are three types of cones in the human retina, the S-cone, M-cone, and L-cone. According to previous studies, the L/M cone ratio in the human retina might be associated with myopia development but requires more evidence.

This study aims to elucidate the effectiveness of using 0.05% atropine and DIMS lenses for myopia control in children with different myopia progression rates, as well as the changes in retinal layers, choroid, and retinal electro-activities due to L/M cones. Hopefully, it will advance our clinical decisions in myopia control.