Chief Supervisor

Dr Jennifer BIAN

Project Title

Synopsis

Myopia is an escalating global public health concern characterized by progressive eyeball elongation, leading to visual impairment. The mechanisms underlying myopia, particularly the role of scleral remodeling, remain poorly understood. This study aims to investigate the mechanisms and potential interventions associated with scleral remodeling in myopic guinea pigs through multi-omics approaches.
We will induce varying degrees of myopia in juvenile guinea pigs and assess ocular biometrics to monitor changes. The molecular mechanisms of scleral remodeling will be evaluated using multiple omics techniques. Potential candidate molecules identified will be further validated at both the gene and protein levels. Additionally, we will examine scleral biomechanics and investigate the structural characteristics of the sclera using advanced imaging techniques. Based on the identified candidates, we aim to develop novel interventions targeting the sclera to control myopia progression, potentially through methods such as cross-linking or pharmacological treatments. Ultimately, this study aims to elucidate the mechanisms involved in myopia development and provide potential therapeutic interventions targeted at scleral remodeling for effective myopia prevention and management.