Chief Supervisor

Prof. Henry CHAN

Project Title

Understanding the association between contrast and electrophysiological changes in retina using chick myopia model

Synopsis

The aim of the proposed research project is to investigate the association between positive and negative contrast modifications in myopia development. It is to understand the mechanism behind the stimulation of ON and OFF pathway resulting in choroidal thickness variation in chicks as an experimental model of myopia.

We will be targeting to answer the following research questions through the above mentioned aim.

1. Will contrast matter be in the path of myopia development?
2. Will the choroidal thickness variation noted, be pertaining to difference in contrast stimulation?
3. Will the difference in contrast stimulation, alter waveforms in PERG with respect to ON and OFF waveforms?

We hypothesise that, the electroretinogram will demonstrate various retinal activities which represent that, positive and negative contrasts impact the ON and OFF contributions respectively. In addition, the choroidal thickness profile following positive contrast imposition is expected to show considerable variations.

By knowing the relationship between the contrast and myopia, we can formulate new strategies to eliminate and avoid inappropriate contrast applications and switch to appropriate contrast applications for new work in children to prevent myopia progression. In future we will also assess the efficacy of contrast modifications through randomised clinical trials in humans.