Malvern MicroCal Automated ITC

Malvern MicroCal PEAQ-ITC Automated Ultrasensitive ITC

Malvern MicroCal Automated Isothermal Titration Calorimeter

Isothermal titration calorimetry (ITC) is an efficient and essential technique in the study of protein interactions and drug discovery. It directly measures the heat released or absorbed during the binding events of any two biomoleculars. Malvern MicroCal PEAQ-ITC automated is a fully automated ITC and allows unattended operation. It offers label-free in solution measurements, eliminates the adverse effect of altering biomolecules. In a direct and single experiment, ITC allows the measurement of binding affinity and thermodynamics, resulting in an accurate determination of binding constants (KD), reaction stoichiometry (n), enthalpy (ΔH) and entropy (ΔS).

Automated units

Specifications:

Measurement parameter: affinity (KD), enphalpy (ΔH), entropy (ΔS) and stoichiometry (n)
Sample capacity: 384 (4 x 96-well plates)
Sample volume: 370 µl
Cell volume: 200 µl
Injection syringe volume: 40 µl
Throughput: Up to 42 reactions per 24 hours

Applications:

Characterising biomolecular interactions
Studying the interaction of any two biomolecules
Drug discovery

Hourly rate

Internal users: $58
Collaborators: $116
External users: $290

Location

Y709

Staff-in-charge

Dr. Alan Leung

Scientific Officer

Dr. Rachel Li

Scientific Officer