ThermoFisher Vitrobot Plunge-freezing Systems

Vitrification refers to the formation of an amorphous solid that does little to no damage to the sample structure and is a critical technique for cellular and structural biology research where samples are cooled so rapidly that the surrounding water molecules do not have time to crystallize. Good vitrification is a crucial step in structural biology applications, such as single particle analysis (SPA), cryo-electron tomography (cryo-ET), and microcrystal electron diffraction (MicroED). The ThermoFisher Vitrobot Mark IV System allows users to perform the vitrification of samples in a precise and reproducible way, thereby ensuring high sample quality for subsequent cryo-EM and cryo-ET workflows.