Thermo Scientific Orbitrap IQ-X LC/MS

The Thermo Scientific Orbitrap IQ-X Liquid Chromatography/Mass Spectrometer (LC/MS) is an ultra-high resolution LC/MS specalised for small molecule analysis. This instrument offers high mass accuracy, high sensitivity, fast acquisition rate and multistage fragmentation (MSⁿ) function, allowing identification of unknown compounds in trace amount with high level of confidence. Besides, it operates with an intelligent and user-friendly data acquisition program, which is built-in with various one-click method templates for convenient execution of different data acquisition modes.

The Thermo Scientific Orbitrap IQ-X LC/MS

System details:

Liquid Chromatography: UltiMate 3000 UHPLC

Two solvent channels (max pressure: 1034 bar)
Autosampler with thermostat
Column oven

Mass Spectrometer: Orbitrap IQ-X

Ionization modes: Electrospray ionization (ESI), Atmospheric-pressure chemical ionization (APCI)
Configuration: Quadrupole-Orbitrap-Ion Trap
Scan modes: MS scan, product ion scan (MS²), multistage fragmentation (MSⁿ), data-dependent acquisition (MS² and MSⁿ)
Mass range: m/z 50 – 2,000
Mass resolution

Maximum: 500,000 (FWHM at m/z 200)
Common: 60,000 and 120,000 (FWHM at m/z 200)

Mass accuracy: 3 ppm with external calibration, 1 ppm with internal calibration

Software:

Xcalibur
Compound Discoverer with m/zCloud library
Mass Frontier
BioPharma Finder
TraceFinder

Major Applications:

Metabolomics
Lipidomics
Identification of drug metabolites
Food analysis
Environmental analysis (e.g., transformation pathway of environmental chemicals)

Natural product analysis

Hourly rate

Internal users: $94
Collaborators: $188
External users: $470

Location

W711

Dr. Pui-kin So

Senior Scientific Officer

Y208
34008797
pui-kin.so@polyu.edu.hk

Dr. Chenyin Wang

Scientific Officer